NPPA (natriuretic peptide A)

2003-05-01  

Identity

HGNC
NPPA
LOCATION
1p36.22
LOCUSID
4878
ALIAS
ANF,ANP,ATFB6,ATRST2,CDD,CDD-ANF,CDP,PND

Other Information

Locus ID:

NCBI: 4878
MIM: 108780
HGNC: 7939
Ensembl: ENSG00000175206

Variants:

dbSNP: 4878
ClinVar: 4878
TCGA: ENSG00000175206
COSMIC: NPPA

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000175206ENST00000376476B0ZBE8
ENSG00000175206ENST00000376480P01160
ENSG00000175206ENST00000610706A0A087X094

Expression (GTEx)

0
5000
10000
15000
20000
25000
30000
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
HIF-1 signaling pathwayKEGGhsa04066
Metabolism of proteinsREACTOMER-HSA-392499
Amyloid fiber formationREACTOMER-HSA-977225
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
YAP1- and WWTR1 (TAZ)-stimulated gene expressionREACTOMER-HSA-2032785
Muscle contractionREACTOMER-HSA-397014
Cardiac conductionREACTOMER-HSA-5576891
Physiological factorsREACTOMER-HSA-5578768

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA166128188systolic blood pressureDiseaseVariantAnnotationassociatedPD18212314
PA443635Cardiovascular DiseasesDiseaseClinicalAnnotationassociatedPD18212314
PA443797Coronary DiseaseDiseaseClinicalAnnotationassociatedPD18212314
PA444552HypertensionDiseaseVariantAnnotationassociatedPD18212314
PA447054StrokeDiseaseClinicalAnnotationassociatedPD18212314
PA448388amlodipineChemicalClinicalAnnotationassociatedPD18212314
PA448970chlorthalidoneChemicalClinicalAnnotation, VariantAnnotationassociatedPD18212314

References

Pubmed IDYearTitleCitations
363369012023Regulatory role of atrial natriuretic peptide in brown adipose tissue: A narrative review.0
370992062023Atrial natriuretic peptide stimulates autophagy/mitophagy and improves mitochondrial function in chronic heart failure.6
374178732023Sex-based differences in metabolic protection by the ANP genetic variant rs5068 in the general population.2
379135062023Corin and Left Atrial Cardiomyopathy, Hypertension, Arrhythmia, and Fibrosis.2
363369012023Regulatory role of atrial natriuretic peptide in brown adipose tissue: A narrative review.0
370992062023Atrial natriuretic peptide stimulates autophagy/mitophagy and improves mitochondrial function in chronic heart failure.6
374178732023Sex-based differences in metabolic protection by the ANP genetic variant rs5068 in the general population.2
379135062023Corin and Left Atrial Cardiomyopathy, Hypertension, Arrhythmia, and Fibrosis.2
348756622022NPPA Promoter Hypomethylation Predicts Central Obesity Development: A Prospective Longitudinal Study in Chinese Adults.0
353939442022Mutant ANP induces mitochondrial and ion channel remodeling in a human iPSC-derived atrial fibrillation model.11
355867482022Serum Atrial Natriuretic Peptide, NPPA Promoter Methylation, and Cardiovascular Disease: A 10-year Follow-Up Study in Chinese Adults.1
348756622022NPPA Promoter Hypomethylation Predicts Central Obesity Development: A Prospective Longitudinal Study in Chinese Adults.0
353939442022Mutant ANP induces mitochondrial and ion channel remodeling in a human iPSC-derived atrial fibrillation model.11
355867482022Serum Atrial Natriuretic Peptide, NPPA Promoter Methylation, and Cardiovascular Disease: A 10-year Follow-Up Study in Chinese Adults.1
328617162021T2238C atrial natriuretic peptide gene variant and cardiovascular events in patients with atrial fibrillation: A substudy from the ATHERO-AF cohort.1

Citation

Dessen P

NPPA (natriuretic peptide A)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/41567/nppa-(natriuretic-peptide-a)