NR1D1 (nuclear receptor subfamily 1 group D member 1)

2003-08-01  

Identity

HGNC
NR1D1
LOCATION
17q21.1
LOCUSID
9572
ALIAS
EAR1,REVERBA,REVERBalpha,THRA1,THRAL,ear-1,hRev
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 9572
MIM: 602408
HGNC: 7962
Ensembl: ENSG00000126368

Variants:

dbSNP: 9572
ClinVar: 9572
TCGA: ENSG00000126368
COSMIC: NR1D1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000126368ENST00000246672P20393
ENSG00000126368ENST00000246672F1D8S3

Expression (GTEx)

0
50
100
150
200
250
300
350
400
450
500
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Circadian rhythmKEGGko04710
Circadian rhythmKEGGhsa04710
Organelle biogenesis and maintenanceREACTOMER-HSA-1852241
Mitochondrial biogenesisREACTOMER-HSA-1592230
Transcriptional activation of mitochondrial biogenesisREACTOMER-HSA-2151201
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Nuclear Receptor transcription pathwayREACTOMER-HSA-383280
Circadian ClockREACTOMER-HSA-400253
BMAL1:CLOCK,NPAS2 activates circadian gene expressionREACTOMER-HSA-1368108
RORA activates gene expressionREACTOMER-HSA-1368082
NR1D1 (REV-ERBA) represses gene expressionREACTOMER-HSA-1368071
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Fatty acid, triacylglycerol, and ketone body metabolismREACTOMER-HSA-535734
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)REACTOMER-HSA-400206
PPARA activates gene expressionREACTOMER-HSA-1989781

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA447199Bipolar DisorderDiseaseClinicalAnnotationassociatedPD20348464
PA450243lithiumChemicalClinicalAnnotationassociatedPD20348464

References

Pubmed IDYearTitleCitations
180067072007Rev-erbalpha, a heme sensor that coordinates metabolic and circadian pathways.294
180378872007Identification of heme as the ligand for the orphan nuclear receptors REV-ERBalpha and REV-ERBbeta.219
164844952006Nuclear receptor Rev-erbalpha is a critical lithium-sensitive component of the circadian clock.160
157610262005The orphan nuclear receptor Rev-erbalpha recruits the N-CoR/histone deacetylase 3 corepressor to regulate the circadian Bmal1 gene.105
200721162010Differential association of circadian genes with mood disorders: CRY1 and NPAS2 are associated with unipolar major depression and CLOCK and VIP with bipolar disorder.91
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
128216522003The orphan nuclear receptor Rev-Erbalpha is a peroxisome proliferator-activated receptor (PPAR) gamma target gene and promotes PPARgamma-induced adipocyte differentiation.79
182285282008Clock genes may influence bipolar disorder susceptibility and dysfunctional circadian rhythm.60
196963642009Rev-erb-alpha: an integrator of circadian rhythms and metabolism.60
197103602009Negative feedback maintenance of heme homeostasis by its receptor, Rev-erbalpha.51

Citation

Dessen P

NR1D1 (nuclear receptor subfamily 1 group D member 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/41569/nr1d1-(nuclear-receptor-subfamily-1-group-d-member-1)