Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 4521
MIM: 600312
HGNC: 8048
Ensembl: ENSG00000106268
Variants:
dbSNP: 4521
ClinVar: 4521
TCGA: ENSG00000106268
COSMIC: NUDT1
RNA/Proteins
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Metabolism | REACTOME | R-HSA-1430728 |
| Metabolism of nucleotides | REACTOME | R-HSA-15869 |
| Phosphate bond hydrolysis by NUDT proteins | REACTOME | R-HSA-2393930 |
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA166153171 | 8-oxo-dgtp | Chemical | MultilinkAnnotation | associated | 26238318 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 36130054 | 2023 | miR-4478 Accelerates Nucleus Pulposus Cells Apoptosis Induced by Oxidative Stress by Targeting MTH1. | 7 |
| 36914375 | 2023 | Protonation states of Asp residues in the human Nudix hydrolase MTH1 contribute to its broad substrate recognition. | 0 |
| 37848855 | 2023 | Fusobacterium nucleatum facilitates proliferation and autophagy by activating miR-361-3p/NUDT1 axis through oxidative stress in hypopharyngeal squamous cell carcinoma. | 2 |
| 36130054 | 2023 | miR-4478 Accelerates Nucleus Pulposus Cells Apoptosis Induced by Oxidative Stress by Targeting MTH1. | 7 |
| 36914375 | 2023 | Protonation states of Asp residues in the human Nudix hydrolase MTH1 contribute to its broad substrate recognition. | 0 |
| 37848855 | 2023 | Fusobacterium nucleatum facilitates proliferation and autophagy by activating miR-361-3p/NUDT1 axis through oxidative stress in hypopharyngeal squamous cell carcinoma. | 2 |
| 35809767 | 2022 | MTH1 suppression enhances the stemness of MCF7 through upregulation of STAT3. | 1 |
| 35809767 | 2022 | MTH1 suppression enhances the stemness of MCF7 through upregulation of STAT3. | 1 |
| 33021405 | 2021 | Oxidized DNA Precursors Cleanup by NUDT1 Contributes to Vascular Remodeling in Pulmonary Arterial Hypertension. | 17 |
| 33096144 | 2021 | The high expression of MTH1 and NUDT5 promotes tumor metastasis and indicates a poor prognosis in patients with non-small-cell lung cancer. | 4 |
| 33130078 | 2021 | MutT Homolog1 has multifaceted role in glioma and is under the apparent orchestration by Hypoxia Inducible factor1 alpha. | 1 |
| 33737576 | 2021 | Karonudib has potent anti-tumor effects in preclinical models of B-cell lymphoma. | 3 |
| 34624481 | 2021 | Specific 8-oxo-dGTPase activity of MTH1 (NUDT1) protein as a quantitative marker and prognostic factor in human colorectal cancer. | 4 |
| 33021405 | 2021 | Oxidized DNA Precursors Cleanup by NUDT1 Contributes to Vascular Remodeling in Pulmonary Arterial Hypertension. | 17 |
| 33096144 | 2021 | The high expression of MTH1 and NUDT5 promotes tumor metastasis and indicates a poor prognosis in patients with non-small-cell lung cancer. | 4 |
Citation
Dessen P
NUDT1 (nudix hydrolase 1)
Atlas Genet Cytogenet Oncol Haematol. 2003-02-01
Online version: http://atlasgeneticsoncology.org/gene/41590/nudt1-(nudix-hydrolase-1)
