NUDT2 (nudix hydrolase 2)

2003-06-01  

Identity

HGNC
LOCATION
9p13.3
LOCUSID
ALIAS
APAH1
FUSION GENES

Other Information

Locus ID:

NCBI: 318
MIM: 602852
HGNC: 8049
Ensembl: ENSG00000164978

Variants:

dbSNP: 318
ClinVar: 318
TCGA: ENSG00000164978
COSMIC: NUDT2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000164978ENST00000346365P50583
ENSG00000164978ENST00000379155P50583
ENSG00000164978ENST00000379158P50583
ENSG00000164978ENST00000618590P50583

Expression (GTEx)

0
10
20
30
40
50
60
70

Pathways

PathwaySourceExternal ID
Purine metabolismKEGGko00230
Pyrimidine metabolismKEGGko00240
Purine metabolismKEGGhsa00230
Pyrimidine metabolismKEGGhsa00240
Cellular responses to stressREACTOMER-HSA-2262752
Detoxification of Reactive Oxygen SpeciesREACTOMER-HSA-3299685

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
381410632024Biallelic NUDT2 variants defective in mRNA decapping cause a neurodevelopmental disease.0
381410632024Biallelic NUDT2 variants defective in mRNA decapping cause a neurodevelopmental disease.0
374456932023Role of Nudt2 in Anchorage-Independent Growth and Cell Migration of Human Melanoma.1
374456932023Role of Nudt2 in Anchorage-Independent Growth and Cell Migration of Human Melanoma.1
348242772021NUDT2 initiates viral RNA degradation by removal of 5'-phosphates.8
348242772021NUDT2 initiates viral RNA degradation by removal of 5'-phosphates.8
280899052017Nudix-type motif 2 contributes to cancer proliferation through the regulation of Rag GTPase-mediated mammalian target of rapamycin complex 1 localization.8
280899052017Nudix-type motif 2 contributes to cancer proliferation through the regulation of Rag GTPase-mediated mammalian target of rapamycin complex 1 localization.8
271444532016NUDT2 Disruption Elevates Diadenosine Tetraphosphate (Ap4A) and Down-Regulates Immune Response and Cancer Promotion Genes.21
271444532016NUDT2 Disruption Elevates Diadenosine Tetraphosphate (Ap4A) and Down-Regulates Immune Response and Cancer Promotion Genes.21
233844402013Crystal structure of wild-type and mutant human Ap4A hydrolase.8
233844402013Crystal structure of wild-type and mutant human Ap4A hydrolase.8
205335492011Nudix-type motif 2 in human breast carcinoma: a potent prognostic factor associated with cell proliferation.24
205335492011Nudix-type motif 2 in human breast carcinoma: a potent prognostic factor associated with cell proliferation.24
201442332010SARS coronavirus protein 7a interacts with human Ap4A-hydrolase.11

Citation

Dessen P

NUDT2 (nudix hydrolase 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/41592/nudt2-(nudix-hydrolase-2)