Identity
HGNC
LOCATION
2p25.1
LOCUSID
ALIAS
BABS,NEDBA,NEDBIA,ODC
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 4953
MIM: 165640
HGNC: 8109
Ensembl: ENSG00000115758
Variants:
dbSNP: 4953
ClinVar: 4953
TCGA: ENSG00000115758
COSMIC: ODC1
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000115758 | ENST00000234111 | P11926 |
| ENSG00000115758 | ENST00000405333 | P11926 |
| ENSG00000115758 | ENST00000443218 | C9JG30 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA446108 | Colorectal Neoplasms | Disease | VariantAnnotation | not associated | PD | ||
| PA448497 | aspirin | Chemical | VariantAnnotation | not associated | PD |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38473716 | 2024 | Effects of Spermine Synthase Deficiency in Mesenchymal Stromal Cells Are Rescued by Upstream Inhibition of Ornithine Decarboxylase. | 0 |
| 38648079 | 2024 | Pirin Promotes the Progression of Non-Small-Cell Lung Cancer by Increasing ODC1 to Suppress Autophagy. | 0 |
| 38743820 | 2024 | FOXA1 co-activates circODC1 and ODC1 in HPV-positive cervical cancer cell growth. | 1 |
| 38473716 | 2024 | Effects of Spermine Synthase Deficiency in Mesenchymal Stromal Cells Are Rescued by Upstream Inhibition of Ornithine Decarboxylase. | 0 |
| 38648079 | 2024 | Pirin Promotes the Progression of Non-Small-Cell Lung Cancer by Increasing ODC1 to Suppress Autophagy. | 0 |
| 38743820 | 2024 | FOXA1 co-activates circODC1 and ODC1 in HPV-positive cervical cancer cell growth. | 1 |
| 35735188 | 2022 | Evaluation of the Influence of Biosurface Design on the Interaction between the Regulatory Peptide RS1-reg and ODC1 Reveals a Membrane-Dependent Affinity Increase. | 0 |
| 35735188 | 2022 | Evaluation of the Influence of Biosurface Design on the Interaction between the Regulatory Peptide RS1-reg and ODC1 Reveals a Membrane-Dependent Affinity Increase. | 0 |
| 33305406 | 2021 | Oesophageal squamous cell carcinoma-associated IL-33 rewires macrophage polarization towards M2 via activating ornithine decarboxylase. | 15 |
| 33806076 | 2021 | Emerging Role of ODC1 in Neurodevelopmental Disorders and Brain Development. | 10 |
| 34282722 | 2021 | Repurposing eflornithine to treat a patient with a rare ODC1 gain-of-function variant disease. | 11 |
| 34376808 | 2021 | Ornithine decarboxylase (ODC1) gene variant (rs2302615) is associated with gastric cancer independently of Helicobacter pylori CagA serostatus. | 2 |
| 34477286 | 2021 | Expanding the phenotype: Four new cases and hope for treatment in Bachmann-Bupp syndrome. | 8 |
| 34796899 | 2021 | Structural basis of binding and inhibition of ornithine decarboxylase by 1-amino-oxy-3-aminopropane. | 3 |
| 33305406 | 2021 | Oesophageal squamous cell carcinoma-associated IL-33 rewires macrophage polarization towards M2 via activating ornithine decarboxylase. | 15 |
Citation
Dessen P
ODC1 (ornithine decarboxylase 1)
Atlas Genet Cytogenet Oncol Haematol. 2003-08-01
Online version: http://atlasgeneticsoncology.org/gene/41603/odc1-(ornithine-decarboxylase-1)
