OXSR1 (oxidative stress responsive kinase 1)

2003-06-01 Affiliation

Identity

HGNC

OXSR1

LOCATION

3p22.2

LOCUSID

9943

ALIAS

OSR1

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 9943
MIM: 604046
HGNC: 8508
Ensembl: ENSG00000172939

Variants:

dbSNP: 9943
ClinVar: 9943
TCGA: ENSG00000172939
COSMIC: OXSR1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000172939	ENST00000311806	O95747
ENSG00000172939	ENST00000311806	A0A024R2M7
ENSG00000172939	ENST00000426620	F8WBK9
ENSG00000172939	ENST00000446845	C9JIG9

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PK	PD	PMIDs
PA320	SLC12A1	Gene	Pathway	associated			23788015
PA38243	STK39	Gene	Pathway	associated			23788015

References

Pubmed ID	Year	Title	Citations
34726826	2022	Structures of the Human SPAK and OSR1 Conserved C-Terminal (CCT) Domains.	1
34983467	2022	Association of genetic variants of oxidative stress responsive kinase 1 (OXSR1) with asthma exacerbations in non-smoking asthmatics.	3
34726826	2022	Structures of the Human SPAK and OSR1 Conserved C-Terminal (CCT) Domains.	1
34983467	2022	Association of genetic variants of oxidative stress responsive kinase 1 (OXSR1) with asthma exacerbations in non-smoking asthmatics.	3
31020807	2020	Association of OSR-1 With Vascular Dysfunction and Hypertension in Polycystic Kidney Disease.	1
31614064	2020	The Cul4-DDB1-WDR3/WDR6 Complex Binds SPAK and OSR1 Kinases in a Phosphorylation-Dependent Manner.	9
32424721	2020	High expression of OSR1 as a predictive biomarker for poor prognosis and lymph node metastasis in breast cancer.	7
32828531	2020	SPAK and OSR1 kinases bind and phosphorylate the β(2)-Adrenergic receptor.	1
31020807	2020	Association of OSR-1 With Vascular Dysfunction and Hypertension in Polycystic Kidney Disease.	1
31614064	2020	The Cul4-DDB1-WDR3/WDR6 Complex Binds SPAK and OSR1 Kinases in a Phosphorylation-Dependent Manner.	9
32424721	2020	High expression of OSR1 as a predictive biomarker for poor prognosis and lymph node metastasis in breast cancer.	7
32828531	2020	SPAK and OSR1 kinases bind and phosphorylate the β(2)-Adrenergic receptor.	1
30894278	2019	Sequence specific assignment and determination of OSR1 C-terminal domain structure by NMR.	1
30894278	2019	Sequence specific assignment and determination of OSR1 C-terminal domain structure by NMR.	1
30054970	2018	Circulating Candidate Biomarkers in Giant Cell Tumors of Bone.	1

Citation

Dessen P

OXSR1 (oxidative stress responsive kinase 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/41617/oxsr1-(oxidative-stress-responsive-kinase-1)