LPAR6 (lysophosphatidic acid receptor 6)

2003-05-01  

Identity

HGNC
LOCATION
13q14.2
LOCUSID
ALIAS
ARWH1,HYPT8,LAH3,LPA-6,P2RY5,P2Y5
FUSION GENES

Other Information

Locus ID:

NCBI: 10161
MIM: 609239
HGNC: 15520
Ensembl: ENSG00000139679

Variants:

dbSNP: 10161
ClinVar: 10161
TCGA: ENSG00000139679
COSMIC: LPAR6

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000139679ENST00000345941P43657
ENSG00000139679ENST00000345941A0A024RDT2
ENSG00000139679ENST00000378434P43657
ENSG00000139679ENST00000378434A0A024RDT2
ENSG00000139679ENST00000620633P43657
ENSG00000139679ENST00000620633A0A024RDT2

Expression (GTEx)

0
10
20
30
40
50
60
70

Pathways

PathwaySourceExternal ID
Neuroactive ligand-receptor interactionKEGGko04080
Neuroactive ligand-receptor interactionKEGGhsa04080
Pathways in cancerKEGGhsa05200
PI3K-Akt signaling pathwayKEGGhsa04151
PI3K-Akt signaling pathwayKEGGko04151
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Nucleotide-like (purinergic) receptorsREACTOMER-HSA-418038
P2Y receptorsREACTOMER-HSA-417957
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (q) signalling eventsREACTOMER-HSA-416476
Gastrin-CREB signalling pathway via PKC and MAPKREACTOMER-HSA-881907
Phospholipase D signaling pathwayKEGGko04072
Phospholipase D signaling pathwayKEGGhsa04072

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
182970702008G protein-coupled receptor P2Y5 and its ligand LPA are involved in maintenance of human hair growth.117
182970722008Disruption of P2RY5, an orphan G protein-coupled receptor, underlies autosomal recessive woolly hair.41
188302682009Mutations in the lipase H gene underlie autosomal recessive woolly hair/hypotrichosis.18
92404601997The 6H1 orphan receptor, claimed to be the p2y5 receptor, does not mediate nucleotide-promoted second messenger responses.13
275834152016Higher LPA2 and LPA6 mRNA Levels in Hepatocellular Carcinoma Are Associated with Poorer Differentiation, Microvascular Invasion and Earlier Recurrence with Higher Serum Autotaxin Levels.13
230849652013Comparing the differential effects of LPA on the barrier function of human pulmonary endothelial cells.12
255893452015Lysophosphatidic acid receptor LPAR6 supports the tumorigenicity of hepatocellular carcinoma.12
184613682008Novel mutations in G protein-coupled receptor gene (P2RY5) in families with autosomal recessive hypotrichosis (LAH3).11
186921272008Genome-wide linkage analysis of an autosomal recessive hypotrichosis identifies a novel P2RY5 mutation.9
188036592009Autosomal recessive woolly hair with hypotrichosis caused by a novel homozygous mutation in the P2RY5 gene.8

Citation

Dessen P

LPAR6 (lysophosphatidic acid receptor 6)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/41626/lpar6-(lysophosphatidic-acid-receptor-6)