PBX2 (PBX homeobox 2)

2003-02-01  

Identity

HGNC
LOCATION
6p21.32
LOCUSID
ALIAS
G17,HOX12,PBX2MHC
FUSION GENES

Other Information

Locus ID:

NCBI: 5089
MIM: 176311
HGNC: 8633
Ensembl: ENSG00000204304

Variants:

dbSNP: 5089
ClinVar: 5089
TCGA: ENSG00000204304
COSMIC: PBX2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000204304ENST00000375050P40425
ENSG00000204304ENST00000375050A0A024RCR3

Expression (GTEx)

0
50
100
150
200

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
198514452009High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions.51
204160772010Identification of type 2 diabetes-associated combination of SNPs using support vector machine.26
128719562003Overexpression of PREP-1 in F9 teratocarcinoma cells leads to a functionally relevant increase of PBX-2 by preventing its degradation.18
234008772013The abrogation of the HOXB7/PBX2 complex induces apoptosis in melanoma through the miR-221&222-c-FOS pathway.18
196598092009Confirmation of the novel association at the BTNL2 locus with ulcerative colitis.15
126098492003Homeodomain proteins MEIS1 and PBXs regulate the lineage-specific transcription of the platelet factor 4 gene.13
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.11
189736872008HOX cofactors expression and regulation in the human ovary.8
193562202009Prognostic significance of pre B cell leukemia transcription factor 2 (PBX2) expression in non-small cell lung carcinoma.7

Citation

Dessen P

PBX2 (PBX homeobox 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/41647/pbx2-(pbx-homeobox-2)