SYT7 (synaptotagmin 7)

2003-02-01  

Identity

HGNC
SYT7
LOCATION
11q12.2
LOCUSID
9066
ALIAS
IPCA-7,IPCA7,PCANAP7,SYT-VII,SYTVII
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 9066
MIM: 604146
HGNC: 11514
Ensembl: ENSG00000011347

Variants:

dbSNP: 9066
ClinVar: 9066
TCGA: ENSG00000011347
COSMIC: SYT7

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000011347ENST00000263846O43581
ENSG00000011347ENST00000535826O43581
ENSG00000011347ENST00000539008O43581
ENSG00000011347ENST00000539246F5GX00
ENSG00000011347ENST00000539468F5GX00
ENSG00000011347ENST00000540677O43581
ENSG00000011347ENST00000542670O43581
ENSG00000011347ENST00000542836O43581
ENSG00000011347ENST00000545053F5H8G7

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Neuronal SystemREACTOMER-HSA-112316
Protein-protein interactions at synapsesREACTOMER-HSA-6794362
Interactions of neurexins and neuroligins at synapsesREACTOMER-HSA-6794361

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
377748262023SYT7 is a key player in increasing exosome secretion and promoting angiogenesis in non-small-cell lung cancer.2
377748262023SYT7 is a key player in increasing exosome secretion and promoting angiogenesis in non-small-cell lung cancer.2
350732782022SYT7 plays a role in promoting thyroid cancer by mediating HMGB3 ubiquitination.5
350732782022SYT7 plays a role in promoting thyroid cancer by mediating HMGB3 ubiquitination.5
316313102020Silencing of synaptotagmin 7 regulates osteosarcoma cell proliferation, apoptosis, and migration.4
320418822020Synaptotagmin-7 is a key factor for bipolar-like behavioral abnormalities in mice.12
328259662020High SYT7 expression is associated with poor prognosis in human non-small cell lung carcinoma.3
330527512020Syt-7 overexpression predicts poor prognosis and promotes cell proliferation in hepatocellular carcinoma.2
332295642020Synaptotagmin-7 deficiency induces mania-like behavioral abnormalities through attenuating GluN2B activity.7
316313102020Silencing of synaptotagmin 7 regulates osteosarcoma cell proliferation, apoptosis, and migration.4
320418822020Synaptotagmin-7 is a key factor for bipolar-like behavioral abnormalities in mice.12
328259662020High SYT7 expression is associated with poor prognosis in human non-small cell lung carcinoma.3
330527512020Syt-7 overexpression predicts poor prognosis and promotes cell proliferation in hepatocellular carcinoma.2
332295642020Synaptotagmin-7 deficiency induces mania-like behavioral abnormalities through attenuating GluN2B activity.7
306471082019Synaptotagmin-7, a binding protein of P53, inhibits the senescence and promotes the tumorigenicity of lung cancer cells.5

Citation

Dessen P

SYT7 (synaptotagmin 7)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/41658/syt7-(synaptotagmin-7)