PECAM1 (platelet and endothelial cell adhesion molecule 1)

2003-08-01

Identity

HGNC

PECAM1

LOCATION

17q23.3

LOCUSID

5175

ALIAS

CD31,CD31/EndoCAM,GPIIA,PECA1,PECAM-1,endoCAM

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 5175
MIM: 173445
HGNC: 8823
Ensembl: ENSG00000261371

Variants:

dbSNP: 5175
ClinVar: 5175
TCGA: ENSG00000261371
COSMIC: PECAM1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000261371	ENST00000563523	A0A075B728
ENSG00000261371	ENST00000563924	P16284
ENSG00000261371	ENST00000564866	A0A075B727
ENSG00000261371	ENST00000569967	A0A075B737

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Expression (GTEx)

100

150

200

250

300

350

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Cell adhesion molecules (CAMs)	KEGG	ko04514
Cell adhesion molecules (CAMs)	KEGG	hsa04514
Cell surface interactions at the vascular wall	REACTOME	R-HSA-202733
Extracellular matrix organization	REACTOME	R-HSA-1474244
Fluid shear stress and atherosclerosis	KEGG	ko05418
Fluid shear stress and atherosclerosis	KEGG	hsa05418
Hemostasis	REACTOME	R-HSA-109582
Immune System	REACTOME	R-HSA-168256
Innate Immune System	REACTOME	R-HSA-168249
Integrin cell surface interactions	REACTOME	R-HSA-216083

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Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
34689374	2022	The expression pattern of CD10 and CD31 identifies fine fibrovascular stroma of grade 1-endometrial endometrioid carcinomas in cytology.	1
34689374	2022	The expression pattern of CD10 and CD31 identifies fine fibrovascular stroma of grade 1-endometrial endometrioid carcinomas in cytology.	1
34937389	2022	Atomic Level Dissection of the Platelet Endothelial Cell Adhesion Molecule 1 (PECAM-1) Homophilic Binding Interface: Implications for Endothelial Cell Barrier Function.	3
34937389	2022	Atomic Level Dissection of the Platelet Endothelial Cell Adhesion Molecule 1 (PECAM-1) Homophilic Binding Interface: Implications for Endothelial Cell Barrier Function.	3
35195045	2023	Elevated shear rate-induced by exercise increases eNOS ser(1177) but not PECAM-1 Tyr(713) phosphorylation in human conduit artery endothelial cells.	2
35195045	2023	Elevated shear rate-induced by exercise increases eNOS ser(1177) but not PECAM-1 Tyr(713) phosphorylation in human conduit artery endothelial cells.	2
35917764	2022	Immunohistochemical analysis of CD31 expression in myocardial tissues from autopsies of patients with ischemic heart disease.	2
35917764	2022	Immunohistochemical analysis of CD31 expression in myocardial tissues from autopsies of patients with ischemic heart disease.	2
36327819	2022	Colon tumor CD31 expression is associated with higher disease-free survival in patients with metabolic syndrome.	0
37051650	2023	CD31 as a probable responding and gate-keeping protein of the blood-brain barrier and the risk of Alzheimer's disease.	2

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Citation

Dessen P

PECAM1 (platelet and endothelial cell adhesion molecule 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/41689