PECAM1 (platelet and endothelial cell adhesion molecule 1)

2003-08-01  

Identity

HGNC
LOCATION
17q23.3
LOCUSID
ALIAS
CD31,CD31/EndoCAM,GPIIA,PECA1,PECAM-1,endoCAM
FUSION GENES

Other Information

Locus ID:

NCBI: 5175
MIM: 173445
HGNC: 8823
Ensembl: ENSG00000261371

Variants:

dbSNP: 5175
ClinVar: 5175
TCGA: ENSG00000261371
COSMIC: PECAM1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000261371ENST00000563523A0A075B728
ENSG00000261371ENST00000563924P16284
ENSG00000261371ENST00000564866A0A075B727
ENSG00000261371ENST00000569967A0A075B737

Expression (GTEx)

0
50
100
150
200
250
300
350

Pathways

PathwaySourceExternal ID
Cell adhesion molecules (CAMs)KEGGko04514
Leukocyte transendothelial migrationKEGGko04670
Cell adhesion molecules (CAMs)KEGGhsa04514
Leukocyte transendothelial migrationKEGGhsa04670
MalariaKEGGko05144
MalariaKEGGhsa05144
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
HemostasisREACTOMER-HSA-109582
Platelet homeostasisREACTOMER-HSA-418346
Platelet sensitization by LDLREACTOMER-HSA-432142
Platelet activation, signaling and aggregationREACTOMER-HSA-76002
Response to elevated platelet cytosolic Ca2+REACTOMER-HSA-76005
Platelet degranulationREACTOMER-HSA-114608
Cell surface interactions at the vascular wallREACTOMER-HSA-202733
PECAM1 interactionsREACTOMER-HSA-210990
Extracellular matrix organizationREACTOMER-HSA-1474244
Integrin cell surface interactionsREACTOMER-HSA-216083
Neutrophil degranulationREACTOMER-HSA-6798695
Fluid shear stress and atherosclerosisKEGGko05418
Fluid shear stress and atherosclerosisKEGGhsa05418

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
351950452023Elevated shear rate-induced by exercise increases eNOS ser(1177) but not PECAM-1 Tyr(713) phosphorylation in human conduit artery endothelial cells.2
370516502023CD31 as a probable responding and gate-keeping protein of the blood-brain barrier and the risk of Alzheimer's disease.2
375807712023PECAM-1 drives β-catenin-mediated EndMT via internalization in colon cancer with diabetes mellitus.0
376582252023CD31 defines a subpopulation of human adipose-derived regenerative cells with potent angiogenic effects.1
351950452023Elevated shear rate-induced by exercise increases eNOS ser(1177) but not PECAM-1 Tyr(713) phosphorylation in human conduit artery endothelial cells.2
370516502023CD31 as a probable responding and gate-keeping protein of the blood-brain barrier and the risk of Alzheimer's disease.2
375807712023PECAM-1 drives β-catenin-mediated EndMT via internalization in colon cancer with diabetes mellitus.0
376582252023CD31 defines a subpopulation of human adipose-derived regenerative cells with potent angiogenic effects.1
346893742022The expression pattern of CD10 and CD31 identifies fine fibrovascular stroma of grade 1-endometrial endometrioid carcinomas in cytology.1
349373892022Atomic Level Dissection of the Platelet Endothelial Cell Adhesion Molecule 1 (PECAM-1) Homophilic Binding Interface: Implications for Endothelial Cell Barrier Function.3
359177642022Immunohistochemical analysis of CD31 expression in myocardial tissues from autopsies of patients with ischemic heart disease.2
363278192022Colon tumor CD31 expression is associated with higher disease-free survival in patients with metabolic syndrome.0
346893742022The expression pattern of CD10 and CD31 identifies fine fibrovascular stroma of grade 1-endometrial endometrioid carcinomas in cytology.1
349373892022Atomic Level Dissection of the Platelet Endothelial Cell Adhesion Molecule 1 (PECAM-1) Homophilic Binding Interface: Implications for Endothelial Cell Barrier Function.3
359177642022Immunohistochemical analysis of CD31 expression in myocardial tissues from autopsies of patients with ischemic heart disease.2

Citation

Dessen P

PECAM1 (platelet and endothelial cell adhesion molecule 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/41689/pecam1-(platelet-and-endothelial-cell-adhesion-molecule-1)