PIK3C2A (phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha)
2003-06-01 AffiliationIdentity
HGNC
LOCATION
11p15.1
LOCUSID
ALIAS
CPK,OCSKD,PI3-K-C2(ALPHA),PI3-K-C2A,PI3K-C2-alpha,PI3K-C2alpha
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 5286
MIM: 603601
HGNC: 8971
Ensembl: ENSG00000011405
Variants:
dbSNP: 5286
ClinVar: 5286
TCGA: ENSG00000011405
COSMIC: PIK3C2A
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000011405 | ENST00000265970 | O00443 |
| ENSG00000011405 | ENST00000265970 | L7RRS0 |
| ENSG00000011405 | ENST00000532035 | E9PPP3 |
| ENSG00000011405 | ENST00000533645 | A0A0C4DGF9 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA134941638 | FGFR1OP | Gene | Pathway | associated | 20124951 | ||
| PA134972108 | FGFR1OP2 | Gene | Pathway | associated | 20124951 | ||
| PA24684 | AKT1 | Gene | Pathway | associated | 20124951, 28362716 | ||
| PA24685 | AKT2 | Gene | Pathway | associated | 20124951 | ||
| PA24686 | AKT3 | Gene | Pathway | associated | 20124951 | ||
| PA28127 | FGFR1 | Gene | Pathway | associated | 20124951 | ||
| PA28128 | FGFR2 | Gene | Pathway | associated | 20124951 | ||
| PA28129 | FGFR3 | Gene | Pathway | associated | 20124951 | ||
| PA28130 | FGFR4 | Gene | Pathway | associated | 20124951 | ||
| PA28131 | FGFR3P1 | Gene | Pathway | associated | 20124951 | ||
| PA28132 | FGFRL1 | Gene | Pathway | associated | 20124951 | ||
| PA28180 | FLT1 | Gene | Pathway | associated | 28362716 | ||
| PA28183 | FLT4 | Gene | Pathway | associated | 28362716 | ||
| PA29457 | HRH2 | Gene | Pathway | associated | |||
| PA30086 | KDR | Gene | Pathway | associated | 28362716 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 36830671 | 2023 | Various Expressions of PIK3C2A and TXNIP Genes and Their Potential Role as Independent Risk Factors for Chronic Stable Angina and Acute Coronary Syndrome. | 2 |
| 36830671 | 2023 | Various Expressions of PIK3C2A and TXNIP Genes and Their Potential Role as Independent Risk Factors for Chronic Stable Angina and Acute Coronary Syndrome. | 2 |
| 33387369 | 2021 | The molecular mechanisms mediating class II PI 3-kinase function in cell physiology. | 6 |
| 33664344 | 2021 | Class II phosphatidylinositol 3-kinase-C2α is essential for Notch signaling by regulating the endocytosis of γ-secretase in endothelial cells. | 8 |
| 34882480 | 2021 | PI(3,4)P2-mediated cytokinetic abscission prevents early senescence and cataract formation. | 23 |
| 33387369 | 2021 | The molecular mechanisms mediating class II PI 3-kinase function in cell physiology. | 6 |
| 33664344 | 2021 | Class II phosphatidylinositol 3-kinase-C2α is essential for Notch signaling by regulating the endocytosis of γ-secretase in endothelial cells. | 8 |
| 34882480 | 2021 | PI(3,4)P2-mediated cytokinetic abscission prevents early senescence and cataract formation. | 23 |
| 31913757 | 2020 | TGFβ receptor endocytosis and Smad signaling require synaptojanin1, PI3K-C2α-, and INPP4B-mediated phosphoinositide conversions. | 12 |
| 31913757 | 2020 | TGFβ receptor endocytosis and Smad signaling require synaptojanin1, PI3K-C2α-, and INPP4B-mediated phosphoinositide conversions. | 12 |
| 30374841 | 2019 | The class II phosphoinositide 3-kinases PI3K-C2α and PI3K-C2β differentially regulate clathrin-dependent pinocytosis in human vascular endothelial cells. | 14 |
| 30946353 | 2019 | Low expression of PIK3C2A gene: A potential biomarker to predict the risk of acute myocardial infarction. | 11 |
| 31034465 | 2019 | Mutations in PIK3C2A cause syndromic short stature, skeletal abnormalities, and cataracts associated with ciliary dysfunction. | 23 |
| 30374841 | 2019 | The class II phosphoinositide 3-kinases PI3K-C2α and PI3K-C2β differentially regulate clathrin-dependent pinocytosis in human vascular endothelial cells. | 14 |
| 30946353 | 2019 | Low expression of PIK3C2A gene: A potential biomarker to predict the risk of acute myocardial infarction. | 11 |
Citation
Dessen P
PIK3C2A (phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha)
Atlas Genet Cytogenet Oncol Haematol. 2003-06-01
Online version: http://atlasgeneticsoncology.org/gene/41711/pik3c2a-(phosphatidylinositol-4-phosphate-3-kinase-catalytic-subunit-type-2-alpha)
