PIK3CB (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta)
2003-08-01 AffiliationIdentity
HGNC
LOCATION
3q22.3
LOCUSID
ALIAS
P110BETA,PI3K,PI3KBETA,PIK3C1
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 5291
MIM: 602925
HGNC: 8976
Ensembl: ENSG00000051382
Variants:
dbSNP: 5291
ClinVar: 5291
TCGA: ENSG00000051382
COSMIC: PIK3CB
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA24684 | AKT1 | Gene | Pathway | associated | 28362716 | ||
| PA27844 | ERBB2 | Gene | Pathway | associated | |||
| PA27846 | ERBB3 | Gene | Pathway | associated | |||
| PA27847 | ERBB4 | Gene | Pathway | associated | |||
| PA28180 | FLT1 | Gene | Pathway | associated | 28362716 | ||
| PA28183 | FLT4 | Gene | Pathway | associated | 28362716 | ||
| PA30086 | KDR | Gene | Pathway | associated | 28362716 | ||
| PA7360 | EGFR | Gene | Pathway | associated |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38713746 | 2024 | Molecular dissection of PI3Kβ synergistic activation by receptor tyrosine kinases, GβGγ, and Rho-family GTPases. | 0 |
| 38757931 | 2024 | PI3K/HSCB axis facilitates FOG1 nuclear translocation to promote erythropoiesis and megakaryopoiesis. | 0 |
| 38713746 | 2024 | Molecular dissection of PI3Kβ synergistic activation by receptor tyrosine kinases, GβGγ, and Rho-family GTPases. | 0 |
| 38757931 | 2024 | PI3K/HSCB axis facilitates FOG1 nuclear translocation to promote erythropoiesis and megakaryopoiesis. | 0 |
| 35225421 | 2023 | HMGB1/PTEN/PI3K axis participates in the peripheral immune cell differentiation in two representative TCM syndromes of chronic hepatitis B patients. | 0 |
| 37036671 | 2023 | AZD8186 in Combination With Paclitaxel in Patients With Advanced Gastric Cancer: Results From a Phase Ib/II Study (KCSG ST18-20). | 4 |
| 37402056 | 2023 | Exosomal PIK3CB promotes PD-L1 expression and malignant transformation in esophageal squamous cell carcinoma. | 0 |
| 35225421 | 2023 | HMGB1/PTEN/PI3K axis participates in the peripheral immune cell differentiation in two representative TCM syndromes of chronic hepatitis B patients. | 0 |
| 37036671 | 2023 | AZD8186 in Combination With Paclitaxel in Patients With Advanced Gastric Cancer: Results From a Phase Ib/II Study (KCSG ST18-20). | 4 |
| 37402056 | 2023 | Exosomal PIK3CB promotes PD-L1 expression and malignant transformation in esophageal squamous cell carcinoma. | 0 |
| 34990021 | 2022 | PIP(3) abundance overcomes PI3K signaling selectivity in invadopodia. | 0 |
| 35459184 | 2022 | CDK6-PI3K signaling axis is an efficient target for attenuating ABCB1/P-gp mediated multi-drug resistance (MDR) in cancer cells. | 14 |
| 36179694 | 2022 | PI3Kβ-regulated β-catenin mediates EZH2 removal from promoters controlling primed human ESC stemness and primitive streak gene expression. | 0 |
| 36197777 | 2022 | Suppression of PI3Kp110β Reduces Cell Viability and Induces Apoptosis in Human Esophageal Cancer. | 1 |
| 34990021 | 2022 | PIP(3) abundance overcomes PI3K signaling selectivity in invadopodia. | 0 |
Citation
Dessen P
PIK3CB (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta)
Atlas Genet Cytogenet Oncol Haematol. 2003-08-01
Online version: http://atlasgeneticsoncology.org/gene/41715/pik3cb-(phosphatidylinositol-4-5-bisphosphate-3-kinase-catalytic-subunit-beta)
