PIK3CB (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta)

2003-08-01 Affiliation

Identity

HGNC

PIK3CB

LOCATION

3q22.3

LOCUSID

5291

ALIAS

P110BETA,PI3K,PI3KBETA,PIK3C1

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 5291
MIM: 602925
HGNC: 8976
Ensembl: ENSG00000051382

Variants:

dbSNP: 5291
ClinVar: 5291
TCGA: ENSG00000051382
COSMIC: PIK3CB

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000051382	ENST00000289153	P42338
ENSG00000051382	ENST00000462294	H7C527
ENSG00000051382	ENST00000462898	F8WDJ8
ENSG00000051382	ENST00000465581	C9J345
ENSG00000051382	ENST00000469284	H7C5C3
ENSG00000051382	ENST00000473435	H7C565
ENSG00000051382	ENST00000477593	P42338
ENSG00000051382	ENST00000483968	C9JYX0
ENSG00000051382	ENST00000493568	H0Y871
ENSG00000051382	ENST00000544716	Q68DL0

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Inositol phosphate metabolism	KEGG	ko00562
ErbB signaling pathway	KEGG	ko04012
Phosphatidylinositol signaling system	KEGG	ko04070
Autophagy - animal	KEGG	ko04140
mTOR signaling pathway	KEGG	ko04150
Apoptosis	KEGG	ko04210
Axon guidance	KEGG	ko04360
VEGF signaling pathway	KEGG	ko04370
Focal adhesion	KEGG	ko04510
Toll-like receptor signaling pathway	KEGG	ko04620
Jak-STAT signaling pathway	KEGG	ko04630
Natural killer cell mediated cytotoxicity	KEGG	ko04650
T cell receptor signaling pathway	KEGG	ko04660
B cell receptor signaling pathway	KEGG	ko04662
Fc epsilon RI signaling pathway	KEGG	ko04664
Leukocyte transendothelial migration	KEGG	ko04670
Regulation of actin cytoskeleton	KEGG	ko04810
Insulin signaling pathway	KEGG	ko04910
Progesterone-mediated oocyte maturation	KEGG	ko04914
Type II diabetes mellitus	KEGG	ko04930
Colorectal cancer	KEGG	ko05210
Renal cell carcinoma	KEGG	ko05211
Pancreatic cancer	KEGG	ko05212
Endometrial cancer	KEGG	ko05213
Glioma	KEGG	ko05214
Prostate cancer	KEGG	ko05215
Melanoma	KEGG	ko05218
Chronic myeloid leukemia	KEGG	ko05220
Acute myeloid leukemia	KEGG	ko05221
Small cell lung cancer	KEGG	ko05222
Non-small cell lung cancer	KEGG	ko05223
Inositol phosphate metabolism	KEGG	hsa00562
ErbB signaling pathway	KEGG	hsa04012
Phosphatidylinositol signaling system	KEGG	hsa04070
Autophagy - animal	KEGG	hsa04140
mTOR signaling pathway	KEGG	hsa04150
Apoptosis	KEGG	hsa04210
Axon guidance	KEGG	hsa04360
VEGF signaling pathway	KEGG	hsa04370
Focal adhesion	KEGG	hsa04510
Toll-like receptor signaling pathway	KEGG	hsa04620
Jak-STAT signaling pathway	KEGG	hsa04630
Natural killer cell mediated cytotoxicity	KEGG	hsa04650
T cell receptor signaling pathway	KEGG	hsa04660
B cell receptor signaling pathway	KEGG	hsa04662
Fc epsilon RI signaling pathway	KEGG	hsa04664
Leukocyte transendothelial migration	KEGG	hsa04670
Regulation of actin cytoskeleton	KEGG	hsa04810
Insulin signaling pathway	KEGG	hsa04910
Type II diabetes mellitus	KEGG	hsa04930
Pathways in cancer	KEGG	hsa05200
Colorectal cancer	KEGG	hsa05210
Renal cell carcinoma	KEGG	hsa05211
Pancreatic cancer	KEGG	hsa05212
Endometrial cancer	KEGG	hsa05213
Glioma	KEGG	hsa05214
Prostate cancer	KEGG	hsa05215
Melanoma	KEGG	hsa05218
Chronic myeloid leukemia	KEGG	hsa05220
Acute myeloid leukemia	KEGG	hsa05221
Small cell lung cancer	KEGG	hsa05222
Non-small cell lung cancer	KEGG	hsa05223
Chemokine signaling pathway	KEGG	ko04062
Chemokine signaling pathway	KEGG	hsa04062
Neurotrophin signaling pathway	KEGG	ko04722
Neurotrophin signaling pathway	KEGG	hsa04722
Fc gamma R-mediated phagocytosis	KEGG	ko04666
Fc gamma R-mediated phagocytosis	KEGG	hsa04666
Progesterone-mediated oocyte maturation	KEGG	hsa04914
Aldosterone-regulated sodium reabsorption	KEGG	ko04960
Aldosterone-regulated sodium reabsorption	KEGG	hsa04960
Chagas disease (American trypanosomiasis)	KEGG	ko05142
Chagas disease (American trypanosomiasis)	KEGG	hsa05142
Bacterial invasion of epithelial cells	KEGG	ko05100
Bacterial invasion of epithelial cells	KEGG	hsa05100
Amoebiasis	KEGG	ko05146
Amoebiasis	KEGG	hsa05146
Carbohydrate digestion and absorption	KEGG	ko04973
Carbohydrate digestion and absorption	KEGG	hsa04973
Hepatitis C	KEGG	ko05160
Hepatitis C	KEGG	hsa05160
Osteoclast differentiation	KEGG	ko04380
Osteoclast differentiation	KEGG	hsa04380
Measles	KEGG	ko05162
Measles	KEGG	hsa05162
Influenza A	KEGG	ko05164
Influenza A	KEGG	hsa05164
Cholinergic synapse	KEGG	hsa04725
HTLV-I infection	KEGG	ko05166
HTLV-I infection	KEGG	hsa05166
Epstein-Barr virus infection	KEGG	hsa05169
Epstein-Barr virus infection	KEGG	ko05169
Viral carcinogenesis	KEGG	hsa05203
Viral carcinogenesis	KEGG	ko05203
PI3K-Akt signaling pathway	KEGG	hsa04151
PI3K-Akt signaling pathway	KEGG	ko04151
Hepatitis B	KEGG	hsa05161
HIF-1 signaling pathway	KEGG	hsa04066
Proteoglycans in cancer	KEGG	hsa05205
Proteoglycans in cancer	KEGG	ko05205
Estrogen signaling pathway	KEGG	hsa04915
Estrogen signaling pathway	KEGG	ko04915
TNF signaling pathway	KEGG	hsa04668
TNF signaling pathway	KEGG	ko04668
Prolactin signaling pathway	KEGG	hsa04917
Prolactin signaling pathway	KEGG	ko04917
Non-alcoholic fatty liver disease (NAFLD)	KEGG	hsa04932
Non-alcoholic fatty liver disease (NAFLD)	KEGG	ko04932
Ras signaling pathway	KEGG	hsa04014
Rap1 signaling pathway	KEGG	hsa04015
Rap1 signaling pathway	KEGG	ko04015
FoxO signaling pathway	KEGG	hsa04068
Thyroid hormone signaling pathway	KEGG	hsa04919
Inflammatory mediator regulation of TRP channels	KEGG	hsa04750
Inflammatory mediator regulation of TRP channels	KEGG	ko04750
Platelet activation	KEGG	hsa04611
AMPK signaling pathway	KEGG	hsa04152
AMPK signaling pathway	KEGG	ko04152
cAMP signaling pathway	KEGG	hsa04024
cAMP signaling pathway	KEGG	ko04024
Signaling pathways regulating pluripotency of stem cells	KEGG	hsa04550
Signaling pathways regulating pluripotency of stem cells	KEGG	ko04550
Central carbon metabolism in cancer	KEGG	hsa05230
Choline metabolism in cancer	KEGG	hsa05231
Central carbon metabolism in cancer	KEGG	ko05230
Choline metabolism in cancer	KEGG	ko05231
PI3K-Akt signaling	KEGG	hsa_M00676
PI3K-Akt signaling	KEGG	M00676
Sphingolipid signaling pathway	KEGG	hsa04071
Sphingolipid signaling pathway	KEGG	ko04071
Regulation of lipolysis in adipocytes	KEGG	hsa04923
Disease	REACTOME	R-HSA-1643685
Diseases of signal transduction	REACTOME	R-HSA-5663202
PI3K/AKT Signaling in Cancer	REACTOME	R-HSA-2219528
Constitutive Signaling by Aberrant PI3K in Cancer	REACTOME	R-HSA-2219530
Immune System	REACTOME	R-HSA-168256
Adaptive Immune System	REACTOME	R-HSA-1280218
TCR signaling	REACTOME	R-HSA-202403
Downstream TCR signaling	REACTOME	R-HSA-202424
Signaling by the B Cell Receptor (BCR)	REACTOME	R-HSA-983705
Downstream signaling events of B Cell Receptor (BCR)	REACTOME	R-HSA-1168372
PIP3 activates AKT signaling	REACTOME	R-HSA-1257604
Negative regulation of the PI3K/AKT network	REACTOME	R-HSA-199418
Innate Immune System	REACTOME	R-HSA-168249
Fcgamma receptor (FCGR) dependent phagocytosis	REACTOME	R-HSA-2029480
Role of phospholipids in phagocytosis	REACTOME	R-HSA-2029485
DAP12 interactions	REACTOME	R-HSA-2172127
DAP12 signaling	REACTOME	R-HSA-2424491
Fc epsilon receptor (FCERI) signaling	REACTOME	R-HSA-2454202
Role of LAT2/NTAL/LAB on calcium mobilization	REACTOME	R-HSA-2730905
Cytokine Signaling in Immune system	REACTOME	R-HSA-1280215
Signaling by Interleukins	REACTOME	R-HSA-449147
Interleukin-2 signaling	REACTOME	R-HSA-451927
Interleukin receptor SHC signaling	REACTOME	R-HSA-912526
Interleukin-3, 5 and GM-CSF signaling	REACTOME	R-HSA-512988
Regulation of signaling by CBL	REACTOME	R-HSA-912631
Hemostasis	REACTOME	R-HSA-109582
Platelet activation, signaling and aggregation	REACTOME	R-HSA-76002
GPVI-mediated activation cascade	REACTOME	R-HSA-114604
Cell surface interactions at the vascular wall	REACTOME	R-HSA-202733
Tie2 Signaling	REACTOME	R-HSA-210993
Signal Transduction	REACTOME	R-HSA-162582
Signaling by EGFR	REACTOME	R-HSA-177929
GAB1 signalosome	REACTOME	R-HSA-180292
Signaling by Insulin receptor	REACTOME	R-HSA-74752
Insulin receptor signalling cascade	REACTOME	R-HSA-74751
IRS-mediated signalling	REACTOME	R-HSA-112399
PI3K Cascade	REACTOME	R-HSA-109704
Signalling by NGF	REACTOME	R-HSA-166520
NGF signalling via TRKA from the plasma membrane	REACTOME	R-HSA-187037
PI3K/AKT activation	REACTOME	R-HSA-198203
Signaling by PDGF	REACTOME	R-HSA-186797
Downstream signal transduction	REACTOME	R-HSA-186763
Signaling by VEGF	REACTOME	R-HSA-194138
VEGFA-VEGFR2 Pathway	REACTOME	R-HSA-4420097
Signaling by SCF-KIT	REACTOME	R-HSA-1433557
Signaling by GPCR	REACTOME	R-HSA-372790
GPCR downstream signaling	REACTOME	R-HSA-388396
G-protein beta:gamma signalling	REACTOME	R-HSA-397795
G beta:gamma signalling through PI3Kgamma	REACTOME	R-HSA-392451
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	REACTOME	R-HSA-2404192
IGF1R signaling cascade	REACTOME	R-HSA-2428924
IRS-related events triggered by IGF1R	REACTOME	R-HSA-2428928
Metabolism	REACTOME	R-HSA-1430728
Metabolism of lipids and lipoproteins	REACTOME	R-HSA-556833
Phospholipid metabolism	REACTOME	R-HSA-1483257
PI Metabolism	REACTOME	R-HSA-1483255
Synthesis of PIPs at the plasma membrane	REACTOME	R-HSA-1660499
Cell-Cell communication	REACTOME	R-HSA-1500931
Nephrin interactions	REACTOME	R-HSA-373753
Developmental Biology	REACTOME	R-HSA-1266738
Axon guidance	REACTOME	R-HSA-422475
Insulin resistance	KEGG	hsa04931
Phospholipase D signaling pathway	KEGG	ko04072
Phospholipase D signaling pathway	KEGG	hsa04072
AGE-RAGE signaling pathway in diabetic complications	KEGG	ko04933
AGE-RAGE signaling pathway in diabetic complications	KEGG	hsa04933
Longevity regulating pathway	KEGG	hsa04211
Longevity regulating pathway - multiple species	KEGG	ko04213
Longevity regulating pathway - multiple species	KEGG	hsa04213
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	REACTOME	R-HSA-6811558
EGFR tyrosine kinase inhibitor resistance	KEGG	ko01521
Platinum drug resistance	KEGG	ko01524
Endocrine resistance	KEGG	ko01522
Platinum drug resistance	KEGG	hsa01524
EGFR tyrosine kinase inhibitor resistance	KEGG	hsa01521
Endocrine resistance	KEGG	hsa01522
RET signaling	REACTOME	R-HSA-8853659
Breast cancer	KEGG	ko05224
Breast cancer	KEGG	hsa05224
Fluid shear stress and atherosclerosis	KEGG	ko05418
Fluid shear stress and atherosclerosis	KEGG	hsa05418

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PMIDs
PA24684	AKT1	Gene	Pathway	associated	28362716
PA27844	ERBB2	Gene	Pathway	associated
PA27846	ERBB3	Gene	Pathway	associated
PA27847	ERBB4	Gene	Pathway	associated
PA28180	FLT1	Gene	Pathway	associated	28362716
PA28183	FLT4	Gene	Pathway	associated	28362716
PA30086	KDR	Gene	Pathway	associated	28362716
PA7360	EGFR	Gene	Pathway	associated

References

Pubmed ID	Year	Title	Citations
38713746	2024	Molecular dissection of PI3Kβ synergistic activation by receptor tyrosine kinases, GβGγ, and Rho-family GTPases.	0
38757931	2024	PI3K/HSCB axis facilitates FOG1 nuclear translocation to promote erythropoiesis and megakaryopoiesis.	0
38713746	2024	Molecular dissection of PI3Kβ synergistic activation by receptor tyrosine kinases, GβGγ, and Rho-family GTPases.	0
38757931	2024	PI3K/HSCB axis facilitates FOG1 nuclear translocation to promote erythropoiesis and megakaryopoiesis.	0
35225421	2023	HMGB1/PTEN/PI3K axis participates in the peripheral immune cell differentiation in two representative TCM syndromes of chronic hepatitis B patients.	0
37036671	2023	AZD8186 in Combination With Paclitaxel in Patients With Advanced Gastric Cancer: Results From a Phase Ib/II Study (KCSG ST18-20).	4
37402056	2023	Exosomal PIK3CB promotes PD-L1 expression and malignant transformation in esophageal squamous cell carcinoma.	0
35225421	2023	HMGB1/PTEN/PI3K axis participates in the peripheral immune cell differentiation in two representative TCM syndromes of chronic hepatitis B patients.	0
37036671	2023	AZD8186 in Combination With Paclitaxel in Patients With Advanced Gastric Cancer: Results From a Phase Ib/II Study (KCSG ST18-20).	4
37402056	2023	Exosomal PIK3CB promotes PD-L1 expression and malignant transformation in esophageal squamous cell carcinoma.	0
34990021	2022	PIP(3) abundance overcomes PI3K signaling selectivity in invadopodia.	0
35459184	2022	CDK6-PI3K signaling axis is an efficient target for attenuating ABCB1/P-gp mediated multi-drug resistance (MDR) in cancer cells.	14
36179694	2022	PI3Kβ-regulated β-catenin mediates EZH2 removal from promoters controlling primed human ESC stemness and primitive streak gene expression.	0
36197777	2022	Suppression of PI3Kp110β Reduces Cell Viability and Induces Apoptosis in Human Esophageal Cancer.	1
34990021	2022	PIP(3) abundance overcomes PI3K signaling selectivity in invadopodia.	0

Citation

Dessen P

PIK3CB (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/41715/pik3cb-(phosphatidylinositol-4-5-bisphosphate-3-kinase-catalytic-subunit-beta)