PIK3CG (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma)
2003-02-01 AffiliationIdentity
HGNC
LOCATION
7q22.3
LOCUSID
ALIAS
PI3CG,PI3K,PI3Kgamma,PIK3,p110gamma,p120-PI3K
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 5294
MIM: 601232
HGNC: 8978
Ensembl: ENSG00000105851
Variants:
dbSNP: 5294
ClinVar: 5294
TCGA: ENSG00000105851
COSMIC: PIK3CG
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA24684 | AKT1 | Gene | Pathway | associated | 28362716 | ||
| PA27844 | ERBB2 | Gene | Pathway | associated | |||
| PA27846 | ERBB3 | Gene | Pathway | associated | |||
| PA27847 | ERBB4 | Gene | Pathway | associated | |||
| PA28180 | FLT1 | Gene | Pathway | associated | 28362716 | ||
| PA28183 | FLT4 | Gene | Pathway | associated | 28362716 | ||
| PA30086 | KDR | Gene | Pathway | associated | 28362716 | ||
| PA7360 | EGFR | Gene | Pathway | associated |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38271660 | 2024 | PI3Kγ maintains the self-renewal of acute myeloid leukemia stem cells by regulating the pentose phosphate pathway. | 1 |
| 38271660 | 2024 | PI3Kγ maintains the self-renewal of acute myeloid leukemia stem cells by regulating the pentose phosphate pathway. | 1 |
| 36779349 | 2023 | Hypoxia Sensing of β-Adrenergic Receptor Is Regulated by Endosomal PI3Kγ. | 2 |
| 36779349 | 2023 | Hypoxia Sensing of β-Adrenergic Receptor Is Regulated by Endosomal PI3Kγ. | 2 |
| 35353541 | 2022 | A PI3Kγ mimetic peptide triggers CFTR gating, bronchodilation, and reduced inflammation in obstructive airway diseases. | 4 |
| 35673779 | 2022 | High expression of the phosphoinositide 3-kinase p11γ isoform can predict poor prognosis of non-small cell lung cancer. | 0 |
| 35725890 | 2022 | PI3Kγ is a novel regulator of TNFα signaling in the human colon cell line HT29/B6. | 0 |
| 35870262 | 2022 | Synonymous mutation rs1129293 is associated with PIK3CG expression and PI3Kγ activation in patients with chronic Chagas cardiomyopathy. | 0 |
| 35353541 | 2022 | A PI3Kγ mimetic peptide triggers CFTR gating, bronchodilation, and reduced inflammation in obstructive airway diseases. | 4 |
| 35673779 | 2022 | High expression of the phosphoinositide 3-kinase p11γ isoform can predict poor prognosis of non-small cell lung cancer. | 0 |
| 35725890 | 2022 | PI3Kγ is a novel regulator of TNFα signaling in the human colon cell line HT29/B6. | 0 |
| 35870262 | 2022 | Synonymous mutation rs1129293 is associated with PIK3CG expression and PI3Kγ activation in patients with chronic Chagas cardiomyopathy. | 0 |
| 33301989 | 2021 | Polymorphism in the catalytic subunit of the PI3Kγ gene is associated with Trypanosoma cruzi-induced chronic chagasic cardiomyopathy. | 1 |
| 33493514 | 2021 | G protein βγ translocation to the Golgi apparatus activates MAPK via p110γ-p101 heterodimers. | 9 |
| 33539876 | 2021 | Biophysical and Structural Characterization of Novel RAS-Binding Domains (RBDs) of PI3Kα and PI3Kγ. | 2 |
Citation
Dessen P
PIK3CG (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma)
Atlas Genet Cytogenet Oncol Haematol. 2003-02-01
Online version: http://atlasgeneticsoncology.org/gene/41716/pik3cg-(phosphatidylinositol-4-5-bisphosphate-3-kinase-catalytic-subunit-gamma)
