PINK1 (PTEN induced kinase 1)

2003-02-01  

Identity

HGNC
LOCATION
1p36.12
LOCUSID
ALIAS
BRPK,PARK6
FUSION GENES

Other Information

Locus ID:

NCBI: 65018
MIM: 608309
HGNC: 14581
Ensembl: ENSG00000158828

Variants:

dbSNP: 65018
ClinVar: 65018
TCGA: ENSG00000158828
COSMIC: PINK1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000158828ENST00000321556Q9BXM7

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90

Pathways

PathwaySourceExternal ID
Parkinson's diseaseKEGGhsa05012
MitophagyREACTOMER-HSA-5205647
Pink/Parkin Mediated MitophagyREACTOMER-HSA-5205685
Mitophagy - animalKEGGko04137
Mitophagy - animalKEGGhsa04137

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
380136002024METTL3/YTHDF2 m6A axis mediates the progression of diabetic nephropathy through epigenetically suppressing PINK1 and mitophagy.2
380551182024Upregulation of UHRF1 Promotes PINK1-mediated Mitophagy to Alleviates Ferroptosis in Diabetic Nephropathy.0
380629722024[Interaction of SENP6 with PINK1 Promotes Temozolomide Resistance in Neuroglioma Cells via Inducing the Mitophagy].0
382514282024PINK1 dominated mitochondria associated genes signature predicts abdominal aortic aneurysm with metabolic syndrome.0
385083122024The SCF-FBW7β E3 ligase mediates ubiquitination and degradation of the serine/threonine protein kinase PINK1.0
387100552024PINK1/Park2-Mediated Mitophagy Relieve Non-Alcoholic Fatty Liver Disease.0
380136002024METTL3/YTHDF2 m6A axis mediates the progression of diabetic nephropathy through epigenetically suppressing PINK1 and mitophagy.2
380551182024Upregulation of UHRF1 Promotes PINK1-mediated Mitophagy to Alleviates Ferroptosis in Diabetic Nephropathy.0
380629722024[Interaction of SENP6 with PINK1 Promotes Temozolomide Resistance in Neuroglioma Cells via Inducing the Mitophagy].0
382514282024PINK1 dominated mitochondria associated genes signature predicts abdominal aortic aneurysm with metabolic syndrome.0
385083122024The SCF-FBW7β E3 ligase mediates ubiquitination and degradation of the serine/threonine protein kinase PINK1.0
387100552024PINK1/Park2-Mediated Mitophagy Relieve Non-Alcoholic Fatty Liver Disease.0
357303182023PINK1-mediated mitophagy reduced inflammatory responses to Porphyromonas gingivalis in macrophages.6
357647232023Upregulation of lncRNA PINK1-AS Predicts the Distant Metastasis of Patients with Small Cell Lung Cancer.2
362014602023RHOA, a small G-protein, signals to mitophagy through regulation of PINK1 protein stability and protects cardiomyocytes against ischemia.0

Citation

Dessen P

PINK1 (PTEN induced kinase 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/41720/pink1-(pten-induced-kinase-1)