PINX1 (PIN2 (TERF1) interacting telomerase inhibitor 1)

2003-02-01  

Identity

HGNC
PINX1
LOCATION
8p23.1
LOCUSID
54984
ALIAS
Gno1,LPTL,LPTS,Pxr1

Other Information

Locus ID:

NCBI: 54984
MIM: 606505
HGNC: 30046
Ensembl: ENSG00000254093

Variants:

dbSNP: 54984
ClinVar: 54984
TCGA: ENSG00000254093
COSMIC: PINX1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000254093ENST00000314787Q96BK5
ENSG00000254093ENST00000519088Q96BK5
ENSG00000254093ENST00000523559E5RJG9
ENSG00000254093ENST00000524061H0YBF0
ENSG00000254093ENST00000524114E5RGR1

Expression (GTEx)

0
5
10
15
20
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
adrenal gland
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
376649232023PinX1-Promoted Autophagy Inhibits Cell Proliferation and Induces Cell Apoptosis by Inhibiting the NF-κB/p65 Signaling Pathway in Nasopharyngeal Carcinoma.0
376649232023PinX1-Promoted Autophagy Inhibits Cell Proliferation and Induces Cell Apoptosis by Inhibiting the NF-κB/p65 Signaling Pathway in Nasopharyngeal Carcinoma.0
336475212021Oncogenic role of PinX1 in prostate cancer cells through androgen receptor dependent and independent mechanisms.0
343370782021Association of the PINX1 Variant rs6984094, Which Lengthens Telomeres, with Systemic Lupus Erythematosus Susceptibility in Chinese Populations.1
336475212021Oncogenic role of PinX1 in prostate cancer cells through androgen receptor dependent and independent mechanisms.0
343370782021Association of the PINX1 Variant rs6984094, Which Lengthens Telomeres, with Systemic Lupus Erythematosus Susceptibility in Chinese Populations.1
310277342019Insufficient PINX1 expression stimulates telomerase activation by direct inhibition of EBV LMP1-NF-κB axis during nasopharyngeal carcinoma development.4
312541272019PinX1 represses renal cancer angiogenesis via the mir-125a-3p/VEGF signaling pathway.12
310277342019Insufficient PINX1 expression stimulates telomerase activation by direct inhibition of EBV LMP1-NF-κB axis during nasopharyngeal carcinoma development.4
312541272019PinX1 represses renal cancer angiogenesis via the mir-125a-3p/VEGF signaling pathway.12
299580612018Efficient expression of recombinant human telomerase inhibitor 1 (hPinX1) in Pichia pastoris.3
300260372018The clinical significance of PINX1 expression in papillary thyroid carcinoma.3
301389442018The Pinx1 Gene Downregulates Telomerase and Inhibits Proliferation of CD133+ Cancer Stem Cells Isolated from a Nasopharyngeal Carcinoma Cell Line by Regulating Trfs and Mad1/C-Myc/p53 Pathways.4
299580612018Efficient expression of recombinant human telomerase inhibitor 1 (hPinX1) in Pichia pastoris.3
300260372018The clinical significance of PINX1 expression in papillary thyroid carcinoma.3

Citation

Dessen P

PINX1 (PIN2 (TERF1) interacting telomerase inhibitor 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/41721/pinx1-(pin2-(terf1)-interacting-telomerase-inhibitor-1)