PLA2G5 (phospholipase A2 group V)

2003-05-01  

Identity

HGNC
LOCATION
1p36.13
LOCUSID
ALIAS
FRFB,GV-PLA2,PLA2-10,hVPLA(2)
FUSION GENES

Other Information

Locus ID:

NCBI: 5322
MIM: 601192
HGNC: 9038
Ensembl: ENSG00000127472

Variants:

dbSNP: 5322
ClinVar: 5322
TCGA: ENSG00000127472
COSMIC: PLA2G5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000127472ENST00000375108P39877

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Glycerophospholipid metabolismKEGGko00564
Ether lipid metabolismKEGGko00565
Arachidonic acid metabolismKEGGko00590
Linoleic acid metabolismKEGGko00591
alpha-Linolenic acid metabolismKEGGko00592
Glycerophospholipid metabolismKEGGhsa00564
Ether lipid metabolismKEGGhsa00565
Arachidonic acid metabolismKEGGhsa00590
Linoleic acid metabolismKEGGhsa00591
alpha-Linolenic acid metabolismKEGGhsa00592
Vascular smooth muscle contractionKEGGhsa04270
Vascular smooth muscle contractionKEGGko04270
Metabolic pathwaysKEGGhsa01100
Pancreatic secretionKEGGko04972
Pancreatic secretionKEGGhsa04972
Fat digestion and absorptionKEGGko04975
Fat digestion and absorptionKEGGhsa04975
Ras signaling pathwayKEGGhsa04014
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Phospholipid metabolismREACTOMER-HSA-1483257
Glycerophospholipid biosynthesisREACTOMER-HSA-1483206
Synthesis of PAREACTOMER-HSA-1483166
Acyl chain remodelling of PEREACTOMER-HSA-1482839
Acyl chain remodelling of PCREACTOMER-HSA-1482788
Acyl chain remodelling of PSREACTOMER-HSA-1482801
Acyl chain remodelling of PIREACTOMER-HSA-1482922
Acyl chain remodelling of PGREACTOMER-HSA-1482925

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
317307732020Degradation of group V secretory phospholipase A(2) in lung endothelium is mediated by autophagy.2
333836522020Lipid Profile of Activated Macrophages and Contribution of Group V Phospholipase A(2).9
317307732020Degradation of group V secretory phospholipase A(2) in lung endothelium is mediated by autophagy.2
333836522020Lipid Profile of Activated Macrophages and Contribution of Group V Phospholipase A(2).9
285284332017Hydrolysis of Phosphatidylcholine-Isoprostanes (PtdCho-IP) by Peripheral Human Group IIA, V and X Secretory Phospholipases A(2) (sPLA(2)).2
285284332017Hydrolysis of Phosphatidylcholine-Isoprostanes (PtdCho-IP) by Peripheral Human Group IIA, V and X Secretory Phospholipases A(2) (sPLA(2)).2
267112212016Hydrolysis of lipoproteins by sPLA2's enhances mitogenesis and eicosanoid release from vascular smooth muscle cells: Diverse activity of sPLA2's IIA, V and X.3
267152692016Epigenetic control of group V phospholipase A2 expression in human malignant cells.6
267112212016Hydrolysis of lipoproteins by sPLA2's enhances mitogenesis and eicosanoid release from vascular smooth muscle cells: Diverse activity of sPLA2's IIA, V and X.3
267152692016Epigenetic control of group V phospholipase A2 expression in human malignant cells.6
255490712015Phospholipase A2 group v in benign familial fleck retina in a set of triplets.3
255490712015Phospholipase A2 group v in benign familial fleck retina in a set of triplets.3
244954802014Endothelial protein C receptor-associated invasiveness of rheumatoid synovial fibroblasts is likely driven by group V secretory phospholipase A2.6
245634182014Novel genetic approach to investigate the role of plasma secretory phospholipase A2 (sPLA2)-V isoenzyme in coronary heart disease: modified Mendelian randomization analysis using PLA2G5 expression levels.6
249595942014The (G>A) rs11573191 polymorphism of PLA2G5 gene is associated with premature coronary artery disease in the Mexican Mestizo population: the genetics of atherosclerotic disease Mexican study.2

Citation

Dessen P

PLA2G5 (phospholipase A2 group V)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/41734/pla2g5-(phospholipase-a2-group-v)