Identity
HGNC
LOCATION
9p21.2
LOCUSID
ALIAS
DOA1,NDMSBA,PLA2P,PLAP
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 9373
MIM: 603873
HGNC: 9043
Ensembl: ENSG00000137055
Variants:
dbSNP: 9373
ClinVar: 9373
TCGA: ENSG00000137055
COSMIC: PLAA
RNA/Proteins
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Protein processing in endoplasmic reticulum | KEGG | ko04141 |
| Protein processing in endoplasmic reticulum | KEGG | hsa04141 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 35869392 | 2022 | PLAA suppresses ovarian cancer metastasis via METTL3-mediated m(6)A modification of TRPC3 mRNA. | 11 |
| 35869392 | 2022 | PLAA suppresses ovarian cancer metastasis via METTL3-mediated m(6)A modification of TRPC3 mRNA. | 11 |
| 27753622 | 2017 | VCP/p97 cooperates with YOD1, UBXD1 and PLAA to drive clearance of ruptured lysosomes by autophagy. | 167 |
| 28007986 | 2017 | Phospholipase A2-activating protein is associated with a novel form of leukoencephalopathy. | 9 |
| 28413018 | 2017 | PLAA Mutations Cause a Lethal Infantile Epileptic Encephalopathy by Disrupting Ubiquitin-Mediated Endolysosomal Degradation of Synaptic Proteins. | 22 |
| 27753622 | 2017 | VCP/p97 cooperates with YOD1, UBXD1 and PLAA to drive clearance of ruptured lysosomes by autophagy. | 167 |
| 28007986 | 2017 | Phospholipase A2-activating protein is associated with a novel form of leukoencephalopathy. | 9 |
| 28413018 | 2017 | PLAA Mutations Cause a Lethal Infantile Epileptic Encephalopathy by Disrupting Ubiquitin-Mediated Endolysosomal Degradation of Synaptic Proteins. | 22 |
| 25448737 | 2015 | Membrane-mediated actions of 1,25-dihydroxy vitamin D3: a review of the roles of phospholipase A2 activating protein and Ca(2+)/calmodulin-dependent protein kinase II. | 24 |
| 25448737 | 2015 | Membrane-mediated actions of 1,25-dihydroxy vitamin D3: a review of the roles of phospholipase A2 activating protein and Ca(2+)/calmodulin-dependent protein kinase II. | 24 |
| 20185149 | 2010 | Gene variants associated with schizophrenia in a Norwegian genome-wide study are replicated in a large European cohort. | 89 |
| 20574843 | 2010 | Associations of 9p21 variants with cutaneous malignant melanoma, nevi, and pigmentation phenotypes in melanoma-prone families with and without CDKN2A mutations. | 21 |
| 20185149 | 2010 | Gene variants associated with schizophrenia in a Norwegian genome-wide study are replicated in a large European cohort. | 89 |
| 20574843 | 2010 | Associations of 9p21 variants with cutaneous malignant melanoma, nevi, and pigmentation phenotypes in melanoma-prone families with and without CDKN2A mutations. | 21 |
| 19423704 | 2009 | Structural basis for ubiquitin recognition by a novel domain from human phospholipase A2-activating protein. | 11 |
Citation
Dessen P
PLAA (phospholipase A2 activating protein)
Atlas Genet Cytogenet Oncol Haematol. 2003-02-01
Online version: http://atlasgeneticsoncology.org/gene/41735/plaa-(phospholipase-a2-activating-protein)
