PLAT (plasminogen activator, tissue type)

2003-08-01  

Identity

HGNC
LOCATION
8p11.21
LOCUSID
ALIAS
T-PA,TPA
FUSION GENES

Other Information

Locus ID:

NCBI: 5327
MIM: 173370
HGNC: 9051
Ensembl: ENSG00000104368

Variants:

dbSNP: 5327
ClinVar: 5327
TCGA: ENSG00000104368
COSMIC: PLAT

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000104368ENST00000220809P00750
ENSG00000104368ENST00000352041P00750
ENSG00000104368ENST00000429089P00750
ENSG00000104368ENST00000429710B4DNJ1
ENSG00000104368ENST00000519510E7ESF4
ENSG00000104368ENST00000520523E5RGA1
ENSG00000104368ENST00000521042H0YBH9
ENSG00000104368ENST00000521694E5RHG4
ENSG00000104368ENST00000524009B4DN26

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Complement and coagulation cascadesKEGGko04610
Complement and coagulation cascadesKEGGhsa04610
Transcriptional misregulation in cancerKEGGko05202
Transcriptional misregulation in cancerKEGGhsa05202
HemostasisREACTOMER-HSA-109582
Dissolution of Fibrin ClotREACTOMER-HSA-75205
Signal TransductionREACTOMER-HSA-162582
Signaling by PDGFREACTOMER-HSA-186797
Fluid shear stress and atherosclerosisKEGGko05418
Fluid shear stress and atherosclerosisKEGGhsa05418
Apelin signaling pathwayKEGGhsa04371

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
155417092004Regulation of late-phase LTP and long-term memory in normal and aging hippocampus: role of secreted proteins tPA and BDNF.102
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
197306832009The variant rs1867277 in FOXE1 gene confers thyroid cancer susceptibility through the recruitment of USF1/USF2 transcription factors.59
191769912008The plasminogen activator system and cancer.54
180379952007Tissue-type plasminogen activator promotes murine myofibroblast activation through LDL receptor-related protein 1-mediated integrin signaling.53
192176512009Ultrasound-enhanced thrombolysis with tPA-loaded echogenic liposomes.52
227783982012Plasminogen activator inhibitor 1--insulin-like growth factor binding protein 3 cascade regulates stress-induced senescence.46
183218602008The functional role of the second NPXY motif of the LRP1 beta-chain in tissue-type plasminogen activator-mediated activation of N-methyl-D-aspartate receptors.44
218687302011Low-dose recombinant tissue-type plasminogen activator enhances clot resolution in brain hemorrhage: the intraventricular hemorrhage thrombolysis trial.40
151199662004An application of conditional logistic regression and multifactor dimensionality reduction for detecting gene-gene interactions on risk of myocardial infarction: the importance of model validation.39

Citation

Dessen P

PLAT (plasminogen activator, tissue type)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/41739/plat-(plasminogen-activator-tissue-type)