Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 5331
MIM: 600230
HGNC: 9056
Ensembl: ENSG00000149782
Variants:
dbSNP: 5331
ClinVar: 5331
TCGA: ENSG00000149782
COSMIC: PLCB3
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000149782 | ENST00000279230 | Q01970 |
| ENSG00000149782 | ENST00000325234 | Q01970 |
| ENSG00000149782 | ENST00000540288 | Q01970 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA134864200 | GNB4 | Gene | Pathway | associated | |||
| PA174 | GNAQ | Gene | Pathway | associated | 19741567 | ||
| PA176 | GNB3 | Gene | Pathway | associated | |||
| PA26097 | CASR | Gene | Pathway | associated | |||
| PA28776 | GNB1 | Gene | Pathway | associated | |||
| PA28777 | GNB1L | Gene | Pathway | associated | |||
| PA28778 | GNB2 | Gene | Pathway | associated | |||
| PA28784 | GNG2 | Gene | Pathway | associated | |||
| PA28785 | GNG3 | Gene | Pathway | associated | |||
| PA28786 | GNG4 | Gene | Pathway | associated | |||
| PA28787 | GNG5 | Gene | Pathway | associated | |||
| PA28789 | GNG7 | Gene | Pathway | associated | |||
| PA33759 | PRKCA | Gene | Pathway | associated | |||
| PA33761 | PRKCB | Gene | Pathway | associated | |||
| PA33766 | PRKCG | Gene | Pathway | associated | |||
| PA33767 | PRKCH | Gene | Pathway | associated | |||
| PA33768 | PRKCI | Gene | Pathway | associated | |||
| PA33771 | PRKD1 | Gene | Pathway | associated | |||
| PA33775 | PRKCZ | Gene | Pathway | associated | |||
| PA39 | ADRB2 | Gene | Pathway | associated |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 33236921 | 2021 | Phospholipase C controls chloride-dependent short-circuit current in human bronchial epithelial cells. | 1 |
| 33236921 | 2021 | Phospholipase C controls chloride-dependent short-circuit current in human bronchial epithelial cells. | 1 |
| 31254604 | 2019 | Intramolecular electrostatic interactions contribute to phospholipase Cβ3 autoinhibition. | 9 |
| 31254604 | 2019 | Intramolecular electrostatic interactions contribute to phospholipase Cβ3 autoinhibition. | 9 |
| 29122926 | 2018 | Defect in phosphoinositide signalling through a homozygous variant in PLCB3 causes a new form of spondylometaphyseal dysplasia with corneal dystrophy. | 4 |
| 29668297 | 2018 | PLCB3 Loss of Function Reduces Pseudomonas aeruginosa-Dependent IL-8 Release in Cystic Fibrosis. | 9 |
| 30237164 | 2018 | OSBP-related protein 4L promotes phospholipase Cβ3 translocation from the nucleus to the plasma membrane in Jurkat T-cells. | 9 |
| 29122926 | 2018 | Defect in phosphoinositide signalling through a homozygous variant in PLCB3 causes a new form of spondylometaphyseal dysplasia with corneal dystrophy. | 4 |
| 29668297 | 2018 | PLCB3 Loss of Function Reduces Pseudomonas aeruginosa-Dependent IL-8 Release in Cystic Fibrosis. | 9 |
| 30237164 | 2018 | OSBP-related protein 4L promotes phospholipase Cβ3 translocation from the nucleus to the plasma membrane in Jurkat T-cells. | 9 |
| 28842497 | 2017 | The binding of activated Gα(q) to phospholipase C-β exhibits anomalous affinity. | 6 |
| 28945350 | 2017 | Phospholipase Cβ3 Membrane Adsorption and Activation Are Regulated by Its C-Terminal Domains and Phosphatidylinositol 4,5-Bisphosphate. | 6 |
| 28842497 | 2017 | The binding of activated Gα(q) to phospholipase C-β exhibits anomalous affinity. | 6 |
| 28945350 | 2017 | Phospholipase Cβ3 Membrane Adsorption and Activation Are Regulated by Its C-Terminal Domains and Phosphatidylinositol 4,5-Bisphosphate. | 6 |
| 26468229 | 2016 | Gnb isoforms control a signaling pathway comprising Rac1, Plcβ2, and Plcβ3 leading to LFA-1 activation and neutrophil arrest in vivo. | 18 |
Citation
Dessen P
PLCB3 (phospholipase C beta 3)
Atlas Genet Cytogenet Oncol Haematol. 2003-02-01
Online version: http://atlasgeneticsoncology.org/gene/41744/plcb3-(phospholipase-c-beta-3)
