PLG (plasminogen)

Identity

HGNC

PLG

LOCATION

6q26

LOCUSID

5340

ALIAS

-

FUSION GENES

Show Gene Fusions

Other Information

Locus ID:

NCBI: 5340
MIM: 173350
HGNC: 9071
Ensembl: ENSG00000122194

Variants:

dbSNP: 5340
ClinVar: 5340
TCGA: ENSG00000122194
COSMIC: PLG

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000122194	ENST00000308192	P00747
ENSG00000122194	ENST00000366924	Q5TEH5
ENSG00000122194	ENST00000418964	A6PVI2

Expression (GTEx)

0

50

100

150

200

250

300

350

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Activation of Matrix Metalloproteinases	REACTOME	R-HSA-1592389
Complement and coagulation cascades	KEGG	ko04610
Complement and coagulation cascades	KEGG	hsa04610
Degradation of the extracellular matrix	REACTOME	R-HSA-1474228
Dissolution of Fibrin Clot	REACTOME	R-HSA-75205
Extracellular matrix organization	REACTOME	R-HSA-1474244
Hemostasis	REACTOME	R-HSA-109582
Influenza A	KEGG	ko05164
Influenza A	KEGG	hsa05164
Metabolism of proteins	REACTOME	R-HSA-392499

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Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
36129033	2023	Case-only design identifies interactions of genetic risk variants at SIGLEC5 and PLG with the lncRNA CTD-2353F22.1 implying the importance of periodontal wound healing for disease aetiology.	3
36129033	2023	Case-only design identifies interactions of genetic risk variants at SIGLEC5 and PLG with the lncRNA CTD-2353F22.1 implying the importance of periodontal wound healing for disease aetiology.	3
36418094	2023	A Missense Mutation of the Plasminogen Gene in a Japanese Family with Hereditary Angioedema with Normal C1 Inhibitor: Third Family Survey in Asia.	0
36675082	2023	Distinguishing Plasmin-Generating Microvesicles: Tiny Messengers Involved in Fibrinolysis and Proteolysis.	4
36763533	2023	Angiopoietin-like protein 4/8 complex-mediated plasmin generation leads to cleavage of the complex and restoration of LPL activity.	8
36766787	2023	The Role of the Plasminogen/Plasmin System in Inflammation of the Oral Cavity.	3
37314019	2023	Increased glutamate in type 2 diabetes in the Korean population is associated with increased plasminogen levels.	1
37495082	2023	Crosstalk between the plasminogen/plasmin system and inflammation resolution.	1
37712947	2023	A dual role for ERK-1/2 in the regulation of plasmin activity and cell migration in metastatic NSCLC-H1299 cells.	0
37971174	2024	Plasminogen deficiency suppresses pancreatic ductal adenocarcinoma disease progression.	0

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Citation

Dessen P

PLG (plasminogen)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/41746/plg-(plasminogen)