PLXDC1 (plexin domain containing 1)

2003-06-01  

Identity

HGNC
LOCATION
17q12
LOCUSID
ALIAS
TEM3,TEM7
FUSION GENES

Other Information

Locus ID:

NCBI: 57125
MIM: 606826
HGNC: 20945
Ensembl: ENSG00000161381

Variants:

dbSNP: 57125
ClinVar: 57125
TCGA: ENSG00000161381
COSMIC: PLXDC1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000161381ENST00000315392Q8IUK5
ENSG00000161381ENST00000415163C9JCL2
ENSG00000161381ENST00000441877C9JWQ3
ENSG00000161381ENST00000444911B4E173
ENSG00000161381ENST00000578390Q8IUK5
ENSG00000161381ENST00000578808J3KS04
ENSG00000161381ENST00000579190J3QR40
ENSG00000161381ENST00000579279J3QRR7

Expression (GTEx)

0
5
10
15
20
25
30

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
260930872015The gain-of-function GLI1 transcription factor TGLI1 enhances expression of VEGF-C and TEM7 to promote glioblastoma angiogenesis.19
183167032008TEM7 (PLXDC1) in neovascular endothelial cells of fibrovascular membranes from patients with proliferative diabetic retinopathy.18
255358412014Identification of PLXDC1 and PLXDC2 as the transmembrane receptors for the multifunctional factor PEDF.18
175600522007High expression of tumor endothelial marker 7 is associated with metastasis and poor survival of patients with osteogenic sarcoma.10
298908522018Selective delivery of PLXDC1 small interfering RNA to endothelial cells for anti-angiogenesis tumor therapy using CD44-targeted chitosan nanoparticles for epithelial ovarian cancer.9
219585272011Tumor endothelial marker 7 (TEM-7): a novel target for antiangiogenic therapy.8
200323732009Preferential expression of the secreted and membrane forms of tumor endothelial marker 7 transcripts in osteosarcoma.2
304141872019Glioblastoma endothelium drives bevacizumab-induced infiltrative growth via modulation of PLXDC1.1
313522222019Serum TEM5 and TEM7 concentrations correlate with clinicopathologic features and poor prognosis of colorectal cancer patients.0

Citation

Dessen P

PLXDC1 (plexin domain containing 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/41752/plxdc1-(plexin-domain-containing-1)