POLQ (DNA polymerase theta)

2003-12-01  

Identity

HGNC
POLQ
LOCATION
3q13.33
LOCUSID
10721
ALIAS
PRO0327
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 10721
MIM: 604419
HGNC: 9186
Ensembl: ENSG00000051341

Variants:

dbSNP: 10721
ClinVar: 10721
TCGA: ENSG00000051341
COSMIC: POLQ

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000051341ENST00000264233O75417
ENSG00000051341ENST00000621776A0A087WXL3

Expression (GTEx)

0
5
10
15
20
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
DNA RepairREACTOMER-HSA-73894
DNA Double-Strand Break RepairREACTOMER-HSA-5693532
Homology Directed RepairREACTOMER-HSA-5693538
HDR through MMEJ (alt-NHEJ)REACTOMER-HSA-5685939

References

Pubmed IDYearTitleCitations
382706432024The m(6)A demethylase FTO targets POLQ to promote ccRCC cell proliferation and genome stability maintenance.1
385755872024POLQ inhibition attenuates the stemness and ferroptosis resistance in gastric cancer cells via downregulation of dihydroorotate dehydrogenase.0
386408892024Human DNA polymerase θ does not harbor intrinsic nuclease activity.2
386715482024Melanoma-Derived DNA Polymerase Theta Variants Exhibit Altered DNA Polymerase Activity.0
387825412024Exosomal circPOLQ promotes macrophage M2 polarization via activating IL-10/STAT3 axis in a colorectal cancer model.0
382706432024The m(6)A demethylase FTO targets POLQ to promote ccRCC cell proliferation and genome stability maintenance.1
385755872024POLQ inhibition attenuates the stemness and ferroptosis resistance in gastric cancer cells via downregulation of dihydroorotate dehydrogenase.0
386408892024Human DNA polymerase θ does not harbor intrinsic nuclease activity.2
386715482024Melanoma-Derived DNA Polymerase Theta Variants Exhibit Altered DNA Polymerase Activity.0
387825412024Exosomal circPOLQ promotes macrophage M2 polarization via activating IL-10/STAT3 axis in a colorectal cancer model.0
357370912023Whole-exome sequencing of Indian prostate cancer reveals a novel therapeutic target: POLQ.2
371539902023[Study on enhanced sensitivity to DNA damage in POLQ knocking-down salivary of adenoid cystic carcinoma-83 cells].0
376740802023Polθ is phosphorylated by PLK1 to repair double-strand breaks in mitosis.18
357370912023Whole-exome sequencing of Indian prostate cancer reveals a novel therapeutic target: POLQ.2
371539902023[Study on enhanced sensitivity to DNA damage in POLQ knocking-down salivary of adenoid cystic carcinoma-83 cells].0

Citation

Dessen P

POLQ (DNA polymerase theta)

Atlas Genet Cytogenet Oncol Haematol. 2003-12-01

Online version: http://atlasgeneticsoncology.org/gene/41779/polq-(dna-polymerase-theta)