PLPP3 (phospholipid phosphatase 3)

2015-10-01  

Identity

HGNC
PLPP3
LOCATION
1p32.2
LOCUSID
8613
ALIAS
Dri42,LPP3,PAP2B,PPAP2B,VCIP
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 8613
MIM: 607125
HGNC: 9229
Ensembl: ENSG00000162407

Variants:

dbSNP: 8613
ClinVar: 8613
TCGA: ENSG00000162407
COSMIC: PLPP3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000162407ENST00000371250O14495

Expression (GTEx)

0
50
100
150
200
250
300
350
400
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Glycerolipid metabolismKEGGko00561
Glycerophospholipid metabolismKEGGko00564
Ether lipid metabolismKEGGko00565
Sphingolipid metabolismKEGGko00600
Glycerolipid metabolismKEGGhsa00561
Glycerophospholipid metabolismKEGGhsa00564
Ether lipid metabolismKEGGhsa00565
Sphingolipid metabolismKEGGhsa00600
Fc gamma R-mediated phagocytosisKEGGko04666
Fc gamma R-mediated phagocytosisKEGGhsa04666
Metabolic pathwaysKEGGhsa01100
Fat digestion and absorptionKEGGko04975
Fat digestion and absorptionKEGGhsa04975
Triacylglycerol biosynthesisKEGGhsa_M00089
Triacylglycerol biosynthesisKEGGM00089
Choline metabolism in cancerKEGGhsa05231
Choline metabolism in cancerKEGGko05231
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Sphingolipid metabolismREACTOMER-HSA-428157
Sphingolipid de novo biosynthesisREACTOMER-HSA-1660661
Phospholipase D signaling pathwayKEGGko04072
Phospholipase D signaling pathwayKEGGhsa04072

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
365756382023Lipid phosphate phosphatase 3 maintains NO-mediated flow-mediated dilatation in human adipose resistance arterioles.2
365756382023Lipid phosphate phosphatase 3 maintains NO-mediated flow-mediated dilatation in human adipose resistance arterioles.2
345024912021Autotaxin-LPA-LPP3 Axis in Energy Metabolism and Metabolic Disease.8
345024912021Autotaxin-LPA-LPP3 Axis in Energy Metabolism and Metabolic Disease.8
323763402020Roles for lysophosphatidic acid signaling in vascular development and disease.12
323763402020Roles for lysophosphatidic acid signaling in vascular development and disease.12
313629882019Regulation of PLPP3 gene expression by NF-κB family transcription factors.9
313629882019Regulation of PLPP3 gene expression by NF-κB family transcription factors.9
297247182018The Autotaxin-Lysophosphatidic Acid Axis Promotes Lung Carcinogenesis.35
297268942018DNA methylation of a PLPP3 MIR transposon-based enhancer promotes an osteogenic programme in calcific aortic valve disease.15
297247182018The Autotaxin-Lysophosphatidic Acid Axis Promotes Lung Carcinogenesis.35
297268942018DNA methylation of a PLPP3 MIR transposon-based enhancer promotes an osteogenic programme in calcific aortic valve disease.15
280614592017Association between PPAP2B gene polymorphisms and coronary heart disease susceptibility in Chinese Han males and females.5
288710442017LPP3 mediates self-generation of chemotactic LPA gradients by melanoma cells.20
280614592017Association between PPAP2B gene polymorphisms and coronary heart disease susceptibility in Chinese Han males and females.5

Citation

Dessen P

PLPP3 (phospholipid phosphatase 3)

Atlas Genet Cytogenet Oncol Haematol. 2015-10-01

Online version: http://atlasgeneticsoncology.org/gene/41791/plpp3-(phospholipid-phosphatase-3)