PLPP3 (phospholipid phosphatase 3)

2015-10-01  

Identity

HGNC
LOCATION
1p32.2
LOCUSID
ALIAS
Dri42,LPP3,PAP2B,PPAP2B,VCIP
FUSION GENES

Other Information

Locus ID:

NCBI: 8613
MIM: 607125
HGNC: 9229
Ensembl: ENSG00000162407

Variants:

dbSNP: 8613
ClinVar: 8613
TCGA: ENSG00000162407
COSMIC: PLPP3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000162407ENST00000371250O14495

Expression (GTEx)

0
50
100
150
200
250
300
350
400

Pathways

PathwaySourceExternal ID
Glycerolipid metabolismKEGGko00561
Glycerophospholipid metabolismKEGGko00564
Ether lipid metabolismKEGGko00565
Sphingolipid metabolismKEGGko00600
Glycerolipid metabolismKEGGhsa00561
Glycerophospholipid metabolismKEGGhsa00564
Ether lipid metabolismKEGGhsa00565
Sphingolipid metabolismKEGGhsa00600
Fc gamma R-mediated phagocytosisKEGGko04666
Fc gamma R-mediated phagocytosisKEGGhsa04666
Metabolic pathwaysKEGGhsa01100
Fat digestion and absorptionKEGGko04975
Fat digestion and absorptionKEGGhsa04975
Triacylglycerol biosynthesisKEGGhsa_M00089
Triacylglycerol biosynthesisKEGGM00089
Choline metabolism in cancerKEGGhsa05231
Choline metabolism in cancerKEGGko05231
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Sphingolipid metabolismREACTOMER-HSA-428157
Sphingolipid de novo biosynthesisREACTOMER-HSA-1660661
Phospholipase D signaling pathwayKEGGko04072
Phospholipase D signaling pathwayKEGGhsa04072

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
175557472007FTY720-phosphate is dephosphorylated by lipid phosphate phosphatase 3.27
260340422015Mechanosensitive PPAP2B Regulates Endothelial Responses to Atherorelevant Hemodynamic Forces.27
128560022003Fly and mammalian lipid phosphate phosphatase isoforms differ in activity both in vitro and in vivo.21
201239642010Lipid phosphate phosphatase 3 stabilization of beta-catenin induces endothelial cell migration and formation of branching point structures.19
182151442008Lipid phosphate phosphatases form homo- and hetero-oligomers: catalytic competency, subcellular distribution and function.13
170055942006Lipid phosphate phosphatases 1 and 3 are localized in distinct lipid rafts.11
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.11
215693062011Lipid phosphate phosphatase-3 regulates tumor growth via β-catenin and CYCLIN-D1 signaling.9
288710442017LPP3 mediates self-generation of chemotactic LPA gradients by melanoma cells.8

Citation

Dessen P

PLPP3 (phospholipid phosphatase 3)

Atlas Genet Cytogenet Oncol Haematol. 2015-10-01

Online version: http://atlasgeneticsoncology.org/gene/41791/plpp3-(phospholipid-phosphatase-3)