PPARGC1A (PPARG coactivator 1 alpha)

2003-08-01  

Identity

HGNC
LOCATION
4p15.2
LOCUSID
ALIAS
LEM6,PGC-1(alpha),PGC-1alpha,PGC-1v,PGC1,PGC1A,PPARGC1
FUSION GENES

Other Information

Locus ID:

NCBI: 10891
MIM: 604517
HGNC: 9237
Ensembl: ENSG00000109819

Variants:

dbSNP: 10891
ClinVar: 10891
TCGA: ENSG00000109819
COSMIC: PPARGC1A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000109819ENST00000264867Q9UBK2
ENSG00000109819ENST00000264867A0A024R9Q9
ENSG00000109819ENST00000506055Q9UBK2
ENSG00000109819ENST00000507380D6RBF3
ENSG00000109819ENST00000513205Q9UBK2
ENSG00000109819ENST00000612355A0A087WVW3
ENSG00000109819ENST00000613098Q9UBK2
ENSG00000109819ENST00000617484A0A087WTJ3

Expression (GTEx)

0
5
10
15
20

Pathways

PathwaySourceExternal ID
Insulin signaling pathwayKEGGko04910
Adipocytokine signaling pathwayKEGGko04920
Huntington's diseaseKEGGko05016
Insulin signaling pathwayKEGGhsa04910
Adipocytokine signaling pathwayKEGGhsa04920
Huntington's diseaseKEGGhsa05016
AMPK signaling pathwayKEGGhsa04152
AMPK signaling pathwayKEGGko04152
Glucagon signaling pathwayKEGGhsa04922
Glucagon signaling pathwayKEGGko04922
Organelle biogenesis and maintenanceREACTOMER-HSA-1852241
Mitochondrial biogenesisREACTOMER-HSA-1592230
Activation of PPARGC1A (PGC-1alpha) by phosphorylationREACTOMER-HSA-2151209
Transcriptional activation of mitochondrial biogenesisREACTOMER-HSA-2151201
Circadian ClockREACTOMER-HSA-400253
BMAL1:CLOCK,NPAS2 activates circadian gene expressionREACTOMER-HSA-1368108
RORA activates gene expressionREACTOMER-HSA-1368082
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Fatty acid, triacylglycerol, and ketone body metabolismREACTOMER-HSA-535734
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)REACTOMER-HSA-400206
PPARA activates gene expressionREACTOMER-HSA-1989781
Developmental BiologyREACTOMER-HSA-1266738
Transcriptional regulation of white adipocyte differentiationREACTOMER-HSA-381340
Insulin resistanceKEGGhsa04931
Longevity regulating pathwayKEGGhsa04211
Apelin signaling pathwayKEGGhsa04371

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA37935SIRT1GenePathwayassociated22722338

References

Pubmed IDYearTitleCitations
377580662024PGC1-α-driven mitochondrial biogenesis contributes to a cancer stem cell phenotype in melanoma.0
382167922024Skeletal muscle TET3 promotes insulin resistance through destabilisation of PGC-1α.0
383610882024PGC1-α in diabetic kidney disease: unraveling renoprotection and molecular mechanisms.0
383953762024Anti-proliferation and apoptosis induced via the mTOR/PGC-1α signaling pathway in trophoblast cells of miscarriage.0
384479392024CLU (clusterin) and PPARGC1A/PGC1α coordinately control mitophagy and mitochondrial biogenesis for oral cancer cell survival.0
388241262024PGC-1α repression dysregulates lipid metabolism and induces lipid droplet accumulation in retinal pigment epithelium.0
377580662024PGC1-α-driven mitochondrial biogenesis contributes to a cancer stem cell phenotype in melanoma.0
382167922024Skeletal muscle TET3 promotes insulin resistance through destabilisation of PGC-1α.0
383610882024PGC1-α in diabetic kidney disease: unraveling renoprotection and molecular mechanisms.0
383953762024Anti-proliferation and apoptosis induced via the mTOR/PGC-1α signaling pathway in trophoblast cells of miscarriage.0
384479392024CLU (clusterin) and PPARGC1A/PGC1α coordinately control mitophagy and mitochondrial biogenesis for oral cancer cell survival.0
388241262024PGC-1α repression dysregulates lipid metabolism and induces lipid droplet accumulation in retinal pigment epithelium.0
356805152023Impacts of altered exercise volume, intensity, and duration on the activation of AMPK and CaMKII and increases in PGC-1α mRNA.4
357137412023PGC-1α participates in tumor chemoresistance by regulating glucose metabolism and mitochondrial function.6
361976332023Low-Nutrient Environment-Induced Changes in Inflammation, Cell Proliferation, and PGC-1α Expression in Stromal Cells with Ovarian Endometriosis.1

Citation

Dessen P

PPARGC1A (PPARG coactivator 1 alpha)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/41795/ppargc1a-(pparg-coactivator-1-alpha)