PPP2R5A (protein phosphatase 2 regulatory subunit Balpha)

2003-11-01 Affiliation

Identity

HGNC

PPP2R5A

LOCATION

1q32.3

LOCUSID

5525

ALIAS

B56A,B56alpha,PR61A

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 5525
MIM: 601643
HGNC: 9309
Ensembl: ENSG00000066027

Variants:

dbSNP: 5525
ClinVar: 5525
TCGA: ENSG00000066027
COSMIC: PPP2R5A

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000066027	ENST00000261461	Q15172
ENSG00000066027	ENST00000537030	Q15172

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Oocyte meiosis	KEGG	ko04114
Oocyte meiosis	KEGG	hsa04114
mRNA surveillance pathway	KEGG	ko03015
mRNA surveillance pathway	KEGG	hsa03015
Dopaminergic synapse	KEGG	ko04728
Dopaminergic synapse	KEGG	hsa04728
PI3K-Akt signaling pathway	KEGG	hsa04151
PI3K-Akt signaling pathway	KEGG	ko04151
Adrenergic signaling in cardiomyocytes	KEGG	hsa04261
Adrenergic signaling in cardiomyocytes	KEGG	ko04261
AMPK signaling pathway	KEGG	hsa04152
AMPK signaling pathway	KEGG	ko04152
Sphingolipid signaling pathway	KEGG	hsa04071
Sphingolipid signaling pathway	KEGG	ko04071
Disease	REACTOME	R-HSA-1643685
Diseases of signal transduction	REACTOME	R-HSA-5663202
Signaling by WNT in cancer	REACTOME	R-HSA-4791275
truncated APC mutants destabilize the destruction complex	REACTOME	R-HSA-4839744
APC truncation mutants have impaired AXIN binding	REACTOME	R-HSA-5467337
AXIN mutants destabilize the destruction complex, activating WNT signaling	REACTOME	R-HSA-4839735
AXIN missense mutants destabilize the destruction complex	REACTOME	R-HSA-5467340
AMER1 mutants destabilize the destruction complex	REACTOME	R-HSA-4839748
Truncations of AMER1 destabilize the destruction complex	REACTOME	R-HSA-5467348
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex	REACTOME	R-HSA-4839743
S45 mutants of beta-catenin aren't phosphorylated	REACTOME	R-HSA-5358751
T41 mutants of beta-catenin aren't phosphorylated	REACTOME	R-HSA-5358752
S37 mutants of beta-catenin aren't phosphorylated	REACTOME	R-HSA-5358749
S33 mutants of beta-catenin aren't phosphorylated	REACTOME	R-HSA-5358747
Misspliced GSK3beta mutants stabilize beta-catenin	REACTOME	R-HSA-5339716
Immune System	REACTOME	R-HSA-168256
Adaptive Immune System	REACTOME	R-HSA-1280218
Costimulation by the CD28 family	REACTOME	R-HSA-388841
CTLA4 inhibitory signaling	REACTOME	R-HSA-389513
Signaling by the B Cell Receptor (BCR)	REACTOME	R-HSA-983705
Downstream signaling events of B Cell Receptor (BCR)	REACTOME	R-HSA-1168372
PIP3 activates AKT signaling	REACTOME	R-HSA-1257604
Negative regulation of the PI3K/AKT network	REACTOME	R-HSA-199418
Innate Immune System	REACTOME	R-HSA-168249
DAP12 interactions	REACTOME	R-HSA-2172127
DAP12 signaling	REACTOME	R-HSA-2424491
RAF/MAP kinase cascade	REACTOME	R-HSA-5673001
RAF activation	REACTOME	R-HSA-5673000
Negative regulation of MAPK pathway	REACTOME	R-HSA-5675221
Fc epsilon receptor (FCERI) signaling	REACTOME	R-HSA-2454202
FCERI mediated MAPK activation	REACTOME	R-HSA-2871796
Role of LAT2/NTAL/LAB on calcium mobilization	REACTOME	R-HSA-2730905
Cytokine Signaling in Immune system	REACTOME	R-HSA-1280215
Signaling by Interleukins	REACTOME	R-HSA-449147
Interleukin-2 signaling	REACTOME	R-HSA-451927
Interleukin receptor SHC signaling	REACTOME	R-HSA-912526
Interleukin-3, 5 and GM-CSF signaling	REACTOME	R-HSA-512988
Hemostasis	REACTOME	R-HSA-109582
Platelet homeostasis	REACTOME	R-HSA-418346
Platelet sensitization by LDL	REACTOME	R-HSA-432142
Signal Transduction	REACTOME	R-HSA-162582
Signaling by EGFR	REACTOME	R-HSA-177929
GRB2 events in EGFR signaling	REACTOME	R-HSA-179812
SHC1 events in EGFR signaling	REACTOME	R-HSA-180336
GAB1 signalosome	REACTOME	R-HSA-180292
Signaling by Insulin receptor	REACTOME	R-HSA-74752
Insulin receptor signalling cascade	REACTOME	R-HSA-74751
IRS-mediated signalling	REACTOME	R-HSA-112399
SOS-mediated signalling	REACTOME	R-HSA-112412
Signalling by NGF	REACTOME	R-HSA-166520
NGF signalling via TRKA from the plasma membrane	REACTOME	R-HSA-187037
Signalling to ERKs	REACTOME	R-HSA-187687
Signalling to RAS	REACTOME	R-HSA-167044
Signalling to p38 via RIT and RIN	REACTOME	R-HSA-187706
Prolonged ERK activation events	REACTOME	R-HSA-169893
Frs2-mediated activation	REACTOME	R-HSA-170968
ARMS-mediated activation	REACTOME	R-HSA-170984
PI3K/AKT activation	REACTOME	R-HSA-198203
Signaling by PDGF	REACTOME	R-HSA-186797
Downstream signal transduction	REACTOME	R-HSA-186763
Signaling by VEGF	REACTOME	R-HSA-194138
VEGFA-VEGFR2 Pathway	REACTOME	R-HSA-4420097
VEGFR2 mediated cell proliferation	REACTOME	R-HSA-5218921
Signaling by SCF-KIT	REACTOME	R-HSA-1433557
MAPK family signaling cascades	REACTOME	R-HSA-5683057
MAPK1/MAPK3 signaling	REACTOME	R-HSA-5684996
Signaling by Rho GTPases	REACTOME	R-HSA-194315
RHO GTPase Effectors	REACTOME	R-HSA-195258
RHO GTPases Activate Formins	REACTOME	R-HSA-5663220
Signaling by GPCR	REACTOME	R-HSA-372790
Gastrin-CREB signalling pathway via PKC and MAPK	REACTOME	R-HSA-881907
Signaling by Wnt	REACTOME	R-HSA-195721
Degradation of beta-catenin by the destruction complex	REACTOME	R-HSA-195253
Beta-catenin phosphorylation cascade	REACTOME	R-HSA-196299
TCF dependent signaling in response to WNT	REACTOME	R-HSA-201681
Disassembly of the destruction complex and recruitment of AXIN to the membrane	REACTOME	R-HSA-4641262
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	REACTOME	R-HSA-2404192
IGF1R signaling cascade	REACTOME	R-HSA-2428924
IRS-related events triggered by IGF1R	REACTOME	R-HSA-2428928
Signaling by Leptin	REACTOME	R-HSA-2586552
Cell Cycle	REACTOME	R-HSA-1640170
Cell Cycle, Mitotic	REACTOME	R-HSA-69278
M Phase	REACTOME	R-HSA-68886
Mitotic Prometaphase	REACTOME	R-HSA-68877
Resolution of Sister Chromatid Cohesion	REACTOME	R-HSA-2500257
Mitotic Metaphase and Anaphase	REACTOME	R-HSA-2555396
Mitotic Anaphase	REACTOME	R-HSA-68882
Separation of Sister Chromatids	REACTOME	R-HSA-2467813
Developmental Biology	REACTOME	R-HSA-1266738
Axon guidance	REACTOME	R-HSA-422475
NCAM signaling for neurite out-growth	REACTOME	R-HSA-375165
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	REACTOME	R-HSA-6811558
RET signaling	REACTOME	R-HSA-8853659

References

Pubmed ID	Year	Title	Citations
34593815	2021	A complex of BRCA2 and PP2A-B56 is required for DNA repair by homologous recombination.	17
34593815	2021	A complex of BRCA2 and PP2A-B56 is required for DNA repair by homologous recombination.	17
32315618	2020	Selective PP2A Enhancement through Biased Heterotrimer Stabilization.	69
32847850	2020	Functional and Structural Insights into a Vif/PPP2R5 Complex Elucidated Using Patient HIV-1 Isolates and Computational Modeling.	6
32315618	2020	Selective PP2A Enhancement through Biased Heterotrimer Stabilization.	69
32847850	2020	Functional and Structural Insights into a Vif/PPP2R5 Complex Elucidated Using Patient HIV-1 Isolates and Computational Modeling.	6
31433993	2019	PP1 and PP2A Use Opposite Phospho-dependencies to Control Distinct Processes at the Kinetochore.	30
31665623	2019	HIV-1 Vif Triggers Cell Cycle Arrest by Degrading Cellular PPP2R5 Phospho-regulators.	18
31433993	2019	PP1 and PP2A Use Opposite Phospho-dependencies to Control Distinct Processes at the Kinetochore.	30
31665623	2019	HIV-1 Vif Triggers Cell Cycle Arrest by Degrading Cellular PPP2R5 Phospho-regulators.	18
29175459	2018	PPP2R5A: A multirole protein phosphatase subunit in regulating cancer development.	14
29175459	2018	PPP2R5A: A multirole protein phosphatase subunit in regulating cancer development.	14
28137908	2017	The PP2A-B56 Phosphatase Opposes Cyclin E Autocatalytic Degradation via Site-Specific Dephosphorylation.	6
28404789	2017	The PP2A(B56) phosphatase promotes the association of Cdc20 with APC/C in mitosis.	19
28849187	2017	MicroRNA-218 promotes cisplatin resistance in oral cancer via the PPP2R5A/Wnt signaling pathway.	19

Citation

Dessen P

PPP2R5A (protein phosphatase 2 regulatory subunit Balpha)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/41818/ppp2r5a-(protein-phosphatase-2-regulatory-subunit-balpha)

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