Identity
HGNC
LOCATION
19q13.32
LOCUSID
ALIAS
PP5,PPP5,PPT
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 5536
MIM: 600658
HGNC: 9322
Ensembl: ENSG00000011485
Variants:
dbSNP: 5536
ClinVar: 5536
TCGA: ENSG00000011485
COSMIC: PPP5C
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000011485 | ENST00000012443 | P53041 |
| ENSG00000011485 | ENST00000012443 | A0A024R0Q7 |
| ENSG00000011485 | ENST00000391919 | A8MU39 |
| ENSG00000011485 | ENST00000478046 | H0YDU8 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 32703456 | 2020 | Over-expression of human PP5 gene in mice induces corneal hyperplasia and leads to ocular surface squamous neoplasia. | 0 |
| 32703456 | 2020 | Over-expression of human PP5 gene in mice induces corneal hyperplasia and leads to ocular surface squamous neoplasia. | 0 |
| 30679389 | 2019 | The Antitumor Drug LB-100 Is a Catalytic Inhibitor of Protein Phosphatase 2A (PPP2CA) and 5 (PPP5C) Coordinating with the Active-Site Catalytic Metals in PPP5C. | 28 |
| 30826056 | 2019 | Exploring the role of active site Mn(2+) ions in the binding of protein phosphatase 5 with its substrate using molecular dynamics simulations. | 1 |
| 30679389 | 2019 | The Antitumor Drug LB-100 Is a Catalytic Inhibitor of Protein Phosphatase 2A (PPP2CA) and 5 (PPP5C) Coordinating with the Active-Site Catalytic Metals in PPP5C. | 28 |
| 30826056 | 2019 | Exploring the role of active site Mn(2+) ions in the binding of protein phosphatase 5 with its substrate using molecular dynamics simulations. | 1 |
| 29343782 | 2018 | Protein phosphatase 5 regulates titin phosphorylation and function at a sarcomere-associated mechanosensor complex in cardiomyocytes. | 24 |
| 30280322 | 2018 | Interactions of cantharidin-like inhibitors with human protein phosphatase-5 in a Mg(2+) system: molecular dynamics and quantum calculations. | 0 |
| 29343782 | 2018 | Protein phosphatase 5 regulates titin phosphorylation and function at a sarcomere-associated mechanosensor complex in cardiomyocytes. | 24 |
| 30280322 | 2018 | Interactions of cantharidin-like inhibitors with human protein phosphatase-5 in a Mg(2+) system: molecular dynamics and quantum calculations. | 0 |
| 27501780 | 2017 | Protein phosphatase 5 mediates corticosteroid insensitivity in airway smooth muscle in patients with severe asthma. | 12 |
| 28534961 | 2017 | Disruption of serine/threonine protein phosphatase 5 inhibits tumorigenesis of urinary bladder cancer cells. | 5 |
| 27501780 | 2017 | Protein phosphatase 5 mediates corticosteroid insensitivity in airway smooth muscle in patients with severe asthma. | 12 |
| 28534961 | 2017 | Disruption of serine/threonine protein phosphatase 5 inhibits tumorigenesis of urinary bladder cancer cells. | 5 |
| 27742828 | 2016 | Cytokine-Induced Glucocorticoid Resistance from Eosinophil Activation: Protein Phosphatase 5 Modulation of Glucocorticoid Receptor Phosphorylation and Signaling. | 17 |
Citation
Dessen P
PPP5C (protein phosphatase 5 catalytic subunit)
Atlas Genet Cytogenet Oncol Haematol. 2003-11-01
Online version: http://atlasgeneticsoncology.org/gene/41825/ppp5c-(protein-phosphatase-5-catalytic-subunit)
