PRAM1 (PML-RARA regulated adaptor molecule 1)

2003-02-01 Affiliation

Identity

HGNC

PRAM1

LOCATION

19p13.2

LOCUSID

84106

ALIAS

PML-RAR,PRAM-1

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 84106
MIM: 606466
HGNC: 30091
Ensembl: ENSG00000133246

Variants:

dbSNP: 84106
ClinVar: 84106
TCGA: ENSG00000133246
COSMIC: PRAM1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000133246	ENST00000423345	Q96QH2
ENSG00000133246	ENST00000600262	M0R149

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
34047481	2021	NRF2 activation induced by PML-RARα promotes microRNA 125b-1 expression and confers resistance to chemotherapy in acute promyelocytic leukemia.	6
34448811	2021	KDM5A suppresses PML-RARα target gene expression and APL differentiation through repressing H3K4me2.	10
34047481	2021	NRF2 activation induced by PML-RARα promotes microRNA 125b-1 expression and confers resistance to chemotherapy in acute promyelocytic leukemia.	6
34448811	2021	KDM5A suppresses PML-RARα target gene expression and APL differentiation through repressing H3K4me2.	10
28431836	2018	Spinal promyelocytic sarcoma as the initial manifestation of acute promyelocytic leukaemia.	0
28431836	2018	Spinal promyelocytic sarcoma as the initial manifestation of acute promyelocytic leukaemia.	0
28317833	2017	Regulation of NF-κB by PML and PML-RARα.	7
28317833	2017	Regulation of NF-κB by PML and PML-RARα.	7
25815789	2015	Development and validation of a 3-Plex RT-qPCR assay for the simultaneous detection and quantitation of the three PML-RARa fusion transcripts in acute promyelocytic leukemia.	3
25944686	2015	Absolute quantification of the pretreatment PML-RARA transcript defines the relapse risk in acute promyelocytic leukemia.	14
25815789	2015	Development and validation of a 3-Plex RT-qPCR assay for the simultaneous detection and quantitation of the three PML-RARa fusion transcripts in acute promyelocytic leukemia.	3
25944686	2015	Absolute quantification of the pretreatment PML-RARA transcript defines the relapse risk in acute promyelocytic leukemia.	14
25126724	2014	MIR125B1 represses the degradation of the PML-RARA oncoprotein by an autophagy-lysosomal pathway in acute promyelocytic leukemia.	24
25126724	2014	MIR125B1 represses the degradation of the PML-RARA oncoprotein by an autophagy-lysosomal pathway in acute promyelocytic leukemia.	24
21673516	2011	PML-RARα enhances constitutive autophagic activity through inhibiting the Akt/mTOR pathway.	19

Citation

Dessen P

PRAM1 (PML-RARA regulated adaptor molecule 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/41827/pram1-(pml-rara-regulated-adaptor-molecule-1)