PRDX2 (peroxiredoxin 2)

2003-10-01  

Identity

HGNC
LOCATION
19p13.13
LOCUSID
ALIAS
HEL-S-2a,NKEF-B,NKEFB,PRP,PRX2,PRXII,PTX1,TDPX1,TPX1,TSA
FUSION GENES

Other Information

Locus ID:

NCBI: 7001
MIM: 600538
HGNC: 9353
Ensembl: ENSG00000167815

Variants:

dbSNP: 7001
ClinVar: 7001
TCGA: ENSG00000167815
COSMIC: PRDX2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000167815ENST00000301522P32119
ENSG00000167815ENST00000301522V9HW12
ENSG00000167815ENST00000334482A6NIW5

Expression (GTEx)

0
100
200
300
400
500
600
700
800
900

Pathways

PathwaySourceExternal ID
DiseaseREACTOMER-HSA-1643685
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Transcriptional Regulation by TP53REACTOMER-HSA-3700989
TP53 Regulates Metabolic GenesREACTOMER-HSA-5628897
Cellular responses to stressREACTOMER-HSA-2262752
Detoxification of Reactive Oxygen SpeciesREACTOMER-HSA-3299685
Neurodegenerative DiseasesREACTOMER-HSA-8863678
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease modelsREACTOMER-HSA-8862803

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA37091TXNGenePathwayassociated23913015

References

Pubmed IDYearTitleCitations
382116802024MiR-92a-2-5p suppresses esophageal squamous cell carcinoma cell proliferation and invasion by targeting PRDX2.0
382194982024Implications and progression of peroxiredoxin 2 (PRDX2) in various human diseases.0
382940692024PRDX2 regulates stemness contributing to cisplatin resistance and metastasis in bladder cancer.0
382116802024MiR-92a-2-5p suppresses esophageal squamous cell carcinoma cell proliferation and invasion by targeting PRDX2.0
382194982024Implications and progression of peroxiredoxin 2 (PRDX2) in various human diseases.0
382940692024PRDX2 regulates stemness contributing to cisplatin resistance and metastasis in bladder cancer.0
364001812023Peroxiredoxin2 regulates trophoblast proliferation and migration through SPIB-HDAC2 pathway.1
368083932023The Study of Overexpression of Peroxiredoxin-2 Reduces MPP(+)-Induced Toxicity in the Cell Model of Parkinson's Disease.2
371606512023Redox-stress response resistance (RRR) mediated by hyperoxidation of peroxiredoxin 2 in senescent cells.0
377587432023Negative pressure wound therapy promotes wound healing of diabetic foot ulcers by up-regulating PRDX2 in wound margin tissue.0
381886792023Silencing of peroxiredoxin 2 suppresses proliferation and Wnt/β-catenin pathway, and induces senescence in hepatocellular carcinoma.1
364001812023Peroxiredoxin2 regulates trophoblast proliferation and migration through SPIB-HDAC2 pathway.1
368083932023The Study of Overexpression of Peroxiredoxin-2 Reduces MPP(+)-Induced Toxicity in the Cell Model of Parkinson's Disease.2
371606512023Redox-stress response resistance (RRR) mediated by hyperoxidation of peroxiredoxin 2 in senescent cells.0
377587432023Negative pressure wound therapy promotes wound healing of diabetic foot ulcers by up-regulating PRDX2 in wound margin tissue.0

Citation

Dessen P

PRDX2 (peroxiredoxin 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-10-01

Online version: http://atlasgeneticsoncology.org/gene/41838/prdx2-(peroxiredoxin-2)