PRG2 (proteoglycan 2, pro eosinophil major basic protein)

2003-02-01  

Identity

HGNC
PRG2
LOCATION
11q12.1
LOCUSID
5553
ALIAS
BMPG,MBP,MBP1,proMBP
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 5553
MIM: 605601
HGNC: 9362
Ensembl: ENSG00000186652

Variants:

dbSNP: 5553
ClinVar: 5553
TCGA: ENSG00000186652
COSMIC: PRG2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000186652ENST00000311862P13727
ENSG00000186652ENST00000525955P13727
ENSG00000186652ENST00000533605P13727

Expression (GTEx)

0
1
2
3
4
5
6
7
8
9
10
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
AsthmaKEGGko05310
AsthmaKEGGhsa05310
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
372784492023Comparison of pancreatic enzyme abnormalities and protease-activated receptor-2-positive eosinophils in the duodenum of patients with functional dyspepsia-irritable bowel syndrome overlap with functional dyspepsia alone in Asian populations.0
372784492023Comparison of pancreatic enzyme abnormalities and protease-activated receptor-2-positive eosinophils in the duodenum of patients with functional dyspepsia-irritable bowel syndrome overlap with functional dyspepsia alone in Asian populations.0
336898072021Development and application of novel immunoassays for eosinophil granule major basic proteins to evaluate eosinophilia and myeloproliferative disorders.1
339820622021PRG2 and AQPEP are misexpressed in fetal membranes in placenta previa and percreta†.2
336898072021Development and application of novel immunoassays for eosinophil granule major basic proteins to evaluate eosinophilia and myeloproliferative disorders.1
339820622021PRG2 and AQPEP are misexpressed in fetal membranes in placenta previa and percreta†.2
315953732020Mechanism of atopic cataract caused by eosinophil granule major basic protein.2
315953732020Mechanism of atopic cataract caused by eosinophil granule major basic protein.2
299367832018Re-Expression of Bone Marrow Proteoglycan-2 by 5-Azacytidine is associated with STAT3 Inactivation and Sensitivity Response to Imatinib in Resistant CML Cells.9
299367832018Re-Expression of Bone Marrow Proteoglycan-2 by 5-Azacytidine is associated with STAT3 Inactivation and Sensitivity Response to Imatinib in Resistant CML Cells.9
252669172015An immunologic test for chronic rhinosinusitis based on free intranasal eosinophilic major basic protein.0
257287692015Toxicity of eosinophil MBP is repressed by intracellular crystallization and promoted by extracellular aggregation.43
252669172015An immunologic test for chronic rhinosinusitis based on free intranasal eosinophilic major basic protein.0
257287692015Toxicity of eosinophil MBP is repressed by intracellular crystallization and promoted by extracellular aggregation.43
248148272014Expression levels of eosinophil granule protein mRNAs in induced sputum reflect airway hyperresponsiveness and airflow limitation.4

Citation

Dessen P

PRG2 (proteoglycan 2, pro eosinophil major basic protein)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/41841/prg2-(proteoglycan-2-pro-eosinophil-major-basic-protein)