PRG4 (proteoglycan 4)

2003-02-01  

Identity

HGNC
PRG4
LOCATION
1q31.1
LOCUSID
10216
ALIAS
CACP,HAPO,JCAP,MSF,SZP

Other Information

Locus ID:

NCBI: 10216
MIM: 604283
HGNC: 9364
Ensembl: ENSG00000116690

Variants:

dbSNP: 10216
ClinVar: 10216
TCGA: ENSG00000116690
COSMIC: PRG4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000116690ENST00000367482J3KP74
ENSG00000116690ENST00000367483Q92954
ENSG00000116690ENST00000367485Q92954
ENSG00000116690ENST00000445192Q92954
ENSG00000116690ENST00000533951E9PLR3
ENSG00000116690ENST00000635041Q92954

Expression (GTEx)

0
10
20
30
40
50
60
70
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
N/A

References

Pubmed IDYearTitleCitations
387817922024PRG4 represses the genesis and metastasis of osteosarcoma by inhibiting PDL1 expression.0
387817922024PRG4 represses the genesis and metastasis of osteosarcoma by inhibiting PDL1 expression.0
366942032023A novel mutation in the proteoglycan 4 gene causing CACP syndrome: two sisters report.1
366942032023A novel mutation in the proteoglycan 4 gene causing CACP syndrome: two sisters report.1
355630632022Regulatory Mechanisms of Prg4 and Gdf5 Expression in Articular Cartilage and Functions in Osteoarthritis.12
357041032022Proteoglycan 4 is present within the dura mater and produced by mesenchymal progenitor cells.2
361090802022Camptodactyly-Arthropathy-Coxa Vara-Pericarditis Syndrome: The First Familial Case in China and Novel Mutations of the Proteoglycan 4 Gene.0
363615042022Recombinant Human Proteoglycan 4 (rhPRG4) Downregulates TNFα-Stimulated NFκB Activity and FAT10 Expression in Human Corneal Epithelial Cells.2
355630632022Regulatory Mechanisms of Prg4 and Gdf5 Expression in Articular Cartilage and Functions in Osteoarthritis.12
357041032022Proteoglycan 4 is present within the dura mater and produced by mesenchymal progenitor cells.2
361090802022Camptodactyly-Arthropathy-Coxa Vara-Pericarditis Syndrome: The First Familial Case in China and Novel Mutations of the Proteoglycan 4 Gene.0
363615042022Recombinant Human Proteoglycan 4 (rhPRG4) Downregulates TNFα-Stimulated NFκB Activity and FAT10 Expression in Human Corneal Epithelial Cells.2
337548832021Interrelationship of MMP-9, Proteoglycan-4, and Inflammation in Osteoarthritis Patients Undergoing Total Hip Arthroplasty.9
340487792021Proteoglycan 4 (PRG4) expression and function in dry eye associated inflammation.11
340639892021Proteoglycan 4 Modulates Osteogenic Smooth Muscle Cell Differentiation during Vascular Remodeling and Intimal Calcification.5

Citation

Dessen P

PRG4 (proteoglycan 4)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/41843/prg4-(proteoglycan-4)