PRIM1 (DNA primase subunit 1)

2003-02-01  

Identity

HGNC
PRIM1
LOCATION
12q13.3
LOCUSID
5557
ALIAS
p49
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 5557
MIM: 176635
HGNC: 9369
Ensembl: ENSG00000198056

Variants:

dbSNP: 5557
ClinVar: 5557
TCGA: ENSG00000198056
COSMIC: PRIM1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000198056ENST00000338193P49642
ENSG00000198056ENST00000549549H0YIP2
ENSG00000198056ENST00000550770F8VNY2
ENSG00000198056ENST00000552590F8VSB2

Expression (GTEx)

0
5
10
15
20
25
30
35
40
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Purine metabolismKEGGko00230
Pyrimidine metabolismKEGGko00240
DNA replicationKEGGko03030
Purine metabolismKEGGhsa00230
Pyrimidine metabolismKEGGhsa00240
DNA replicationKEGGhsa03030
Metabolic pathwaysKEGGhsa01100
DNA polymerase alpha / primase complexKEGGhsa_M00261
DNA polymerase alpha / primase complexKEGGM00261
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
Mitotic G1-G1/S phasesREACTOMER-HSA-453279
G1/S TransitionREACTOMER-HSA-69206
Activation of the pre-replicative complexREACTOMER-HSA-68962
E2F mediated regulation of DNA replicationREACTOMER-HSA-113510
Inhibition of replication initiation of damaged DNA by RB1/E2F1REACTOMER-HSA-113501
S PhaseREACTOMER-HSA-69242
Synthesis of DNAREACTOMER-HSA-69239
DNA replication initiationREACTOMER-HSA-68952
DNA strand elongationREACTOMER-HSA-69190
Leading Strand SynthesisREACTOMER-HSA-69109
Polymerase switchingREACTOMER-HSA-69091
Lagging Strand SynthesisREACTOMER-HSA-69186
Processive synthesis on the lagging strandREACTOMER-HSA-69183
Removal of the Flap IntermediateREACTOMER-HSA-69166
M/G1 TransitionREACTOMER-HSA-68874
DNA Replication Pre-InitiationREACTOMER-HSA-69002
Chromosome MaintenanceREACTOMER-HSA-73886
Telomere MaintenanceREACTOMER-HSA-157579
Extension of TelomeresREACTOMER-HSA-180786
Telomere C-strand (Lagging Strand) SynthesisREACTOMER-HSA-174417
Telomere C-strand synthesis initiationREACTOMER-HSA-174430
Polymerase switching on the C-strand of the telomereREACTOMER-HSA-174411
DNA ReplicationREACTOMER-HSA-69306

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
387730122024Variable Syndromic Immunodeficiency in Patients with Biallelic PRIM1 Mutations.0
387730122024Variable Syndromic Immunodeficiency in Patients with Biallelic PRIM1 Mutations.0
343766932021Small tandem DNA duplications result from CST-guided Pol α-primase action at DNA break termini.18
343766932021Small tandem DNA duplications result from CST-guided Pol α-primase action at DNA break termini.18
329089302020DNA Primase Subunit 1 Expression in Hepatocellular Carcinoma and Its Clinical Implication.1
329089302020DNA Primase Subunit 1 Expression in Hepatocellular Carcinoma and Its Clinical Implication.1
300979992019DNA primase polypeptide 1 (PRIM1) involves in estrogen-induced breast cancer formation through activation of the G2/M cell cycle checkpoint.15
300979992019DNA primase polypeptide 1 (PRIM1) involves in estrogen-induced breast cancer formation through activation of the G2/M cell cycle checkpoint.15
302572222018Inactivation of PRIM1 Function Sensitizes Cancer Cells to ATR and CHK1 Inhibitors.13
304462202018Structural and biochemical insights into inhibition of human primase by citrate.2
302572222018Inactivation of PRIM1 Function Sensitizes Cancer Cells to ATR and CHK1 Inhibitors.13
304462202018Structural and biochemical insights into inhibition of human primase by citrate.2
267108482016Insight into the Human DNA Primase Interaction with Template-Primer.41
275997562016Variation analysis of PRIM1 gene in Chinese patients with primary ovarian insufficiency.3
267108482016Insight into the Human DNA Primase Interaction with Template-Primer.41

Citation

Dessen P

PRIM1 (DNA primase subunit 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/41844/prim1-(dna-primase-subunit-1)