PRKCA (protein kinase C alpha)

2003-05-01 Affiliation

Identity

HGNC

PRKCA

LOCATION

17q24.2

LOCUSID

5578

ALIAS

AAG6,PKC-alpha,PKCA,PKCI+/-,PKCalpha,PRKACA

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 5578
MIM: 176960
HGNC: 9393
Ensembl: ENSG00000154229

Variants:

dbSNP: 5578
ClinVar: 5578
TCGA: ENSG00000154229
COSMIC: PRKCA

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000154229	ENST00000284384	J3KN97
ENSG00000154229	ENST00000413366	P17252
ENSG00000154229	ENST00000413366	L7RSM7
ENSG00000154229	ENST00000578063	J3KRN5

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
MAPK signaling pathway	KEGG	ko04010
ErbB signaling pathway	KEGG	ko04012
Calcium signaling pathway	KEGG	ko04020
Phosphatidylinositol signaling system	KEGG	ko04070
mTOR signaling pathway	KEGG	ko04150
Wnt signaling pathway	KEGG	ko04310
Axon guidance	KEGG	ko04360
VEGF signaling pathway	KEGG	ko04370
Focal adhesion	KEGG	ko04510
Gap junction	KEGG	ko04540
Natural killer cell mediated cytotoxicity	KEGG	ko04650
Fc epsilon RI signaling pathway	KEGG	ko04664
Leukocyte transendothelial migration	KEGG	ko04670
Long-term potentiation	KEGG	ko04720
Long-term depression	KEGG	ko04730
GnRH signaling pathway	KEGG	ko04912
Melanogenesis	KEGG	ko04916
Vibrio cholerae infection	KEGG	ko05110
Pathogenic Escherichia coli infection	KEGG	ko05130
Glioma	KEGG	ko05214
Non-small cell lung cancer	KEGG	ko05223
MAPK signaling pathway	KEGG	hsa04010
ErbB signaling pathway	KEGG	hsa04012
Calcium signaling pathway	KEGG	hsa04020
Phosphatidylinositol signaling system	KEGG	hsa04070
mTOR signaling pathway	KEGG	hsa04150
Wnt signaling pathway	KEGG	hsa04310
Axon guidance	KEGG	hsa04360
VEGF signaling pathway	KEGG	hsa04370
Focal adhesion	KEGG	hsa04510
Gap junction	KEGG	hsa04540
Natural killer cell mediated cytotoxicity	KEGG	hsa04650
Fc epsilon RI signaling pathway	KEGG	hsa04664
Leukocyte transendothelial migration	KEGG	hsa04670
Long-term potentiation	KEGG	hsa04720
Long-term depression	KEGG	hsa04730
GnRH signaling pathway	KEGG	hsa04912
Melanogenesis	KEGG	hsa04916
Vibrio cholerae infection	KEGG	hsa05110
Pathogenic Escherichia coli infection	KEGG	hsa05130
Pathways in cancer	KEGG	hsa05200
Glioma	KEGG	hsa05214
Non-small cell lung cancer	KEGG	hsa05223
Vascular smooth muscle contraction	KEGG	hsa04270
Vascular smooth muscle contraction	KEGG	ko04270
Fc gamma R-mediated phagocytosis	KEGG	ko04666
Fc gamma R-mediated phagocytosis	KEGG	hsa04666
Aldosterone-regulated sodium reabsorption	KEGG	ko04960
Aldosterone-regulated sodium reabsorption	KEGG	hsa04960
Salivary secretion	KEGG	ko04970
Salivary secretion	KEGG	hsa04970
Gastric acid secretion	KEGG	ko04971
Gastric acid secretion	KEGG	hsa04971
Amoebiasis	KEGG	ko05146
Amoebiasis	KEGG	hsa05146
Pancreatic secretion	KEGG	ko04972
Pancreatic secretion	KEGG	hsa04972
African trypanosomiasis	KEGG	ko05143
African trypanosomiasis	KEGG	hsa05143
Endocrine and other factor-regulated calcium reabsorption	KEGG	ko04961
Endocrine and other factor-regulated calcium reabsorption	KEGG	hsa04961
Glutamatergic synapse	KEGG	ko04724
Glutamatergic synapse	KEGG	hsa04724
Influenza A	KEGG	ko05164
Influenza A	KEGG	hsa05164
Cholinergic synapse	KEGG	hsa04725
GABAergic synapse	KEGG	ko04727
GABAergic synapse	KEGG	hsa04727
Dopaminergic synapse	KEGG	ko04728
Dopaminergic synapse	KEGG	hsa04728
Serotonergic synapse	KEGG	hsa04726
Retrograde endocannabinoid signaling	KEGG	hsa04723
Retrograde endocannabinoid signaling	KEGG	ko04723
Amphetamine addiction	KEGG	hsa05031
Amphetamine addiction	KEGG	ko05031
Morphine addiction	KEGG	hsa05032
Morphine addiction	KEGG	ko05032
PI3K-Akt signaling pathway	KEGG	hsa04151
PI3K-Akt signaling pathway	KEGG	ko04151
Hepatitis B	KEGG	hsa05161
HIF-1 signaling pathway	KEGG	hsa04066
Circadian entrainment	KEGG	hsa04713
Circadian entrainment	KEGG	ko04713
Insulin secretion	KEGG	hsa04911
Proteoglycans in cancer	KEGG	hsa05205
Proteoglycans in cancer	KEGG	ko05205
Thyroid hormone synthesis	KEGG	hsa04918
Thyroid hormone synthesis	KEGG	ko04918
MicroRNAs in cancer	KEGG	hsa05206
MicroRNAs in cancer	KEGG	ko05206
Ras signaling pathway	KEGG	hsa04014
Rap1 signaling pathway	KEGG	hsa04015
Rap1 signaling pathway	KEGG	ko04015
Adrenergic signaling in cardiomyocytes	KEGG	hsa04261
Adrenergic signaling in cardiomyocytes	KEGG	ko04261
Thyroid hormone signaling pathway	KEGG	hsa04919
Inflammatory mediator regulation of TRP channels	KEGG	hsa04750
Inflammatory mediator regulation of TRP channels	KEGG	ko04750
Oxytocin signaling pathway	KEGG	hsa04921
Oxytocin signaling pathway	KEGG	ko04921
Choline metabolism in cancer	KEGG	hsa05231
Choline metabolism in cancer	KEGG	ko05231
Sphingolipid signaling pathway	KEGG	hsa04071
Sphingolipid signaling pathway	KEGG	ko04071
Neuronal System	REACTOME	R-HSA-112316
Transmission across Chemical Synapses	REACTOME	R-HSA-112315
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell	REACTOME	R-HSA-112314
Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity	REACTOME	R-HSA-399721
Trafficking of AMPA receptors	REACTOME	R-HSA-399719
Trafficking of GluR2-containing AMPA receptors	REACTOME	R-HSA-416993
Immune System	REACTOME	R-HSA-168256
Innate Immune System	REACTOME	R-HSA-168249
DAP12 interactions	REACTOME	R-HSA-2172127
DAP12 signaling	REACTOME	R-HSA-2424491
DAG and IP3 signaling	REACTOME	R-HSA-1489509
CaM pathway	REACTOME	R-HSA-111997
Calmodulin induced events	REACTOME	R-HSA-111933
Hemostasis	REACTOME	R-HSA-109582
Platelet activation, signaling and aggregation	REACTOME	R-HSA-76002
Response to elevated platelet cytosolic Ca2+	REACTOME	R-HSA-76005
Disinhibition of SNARE formation	REACTOME	R-HSA-114516
Signal Transduction	REACTOME	R-HSA-162582
Signaling by EGFR	REACTOME	R-HSA-177929
EGFR interacts with phospholipase C-gamma	REACTOME	R-HSA-212718
Signalling by NGF	REACTOME	R-HSA-166520
NGF signalling via TRKA from the plasma membrane	REACTOME	R-HSA-187037
PLC-gamma1 signalling	REACTOME	R-HSA-167021
Signaling by PDGF	REACTOME	R-HSA-186797
Downstream signal transduction	REACTOME	R-HSA-186763
Signaling by VEGF	REACTOME	R-HSA-194138
VEGFA-VEGFR2 Pathway	REACTOME	R-HSA-4420097
VEGFR2 mediated cell proliferation	REACTOME	R-HSA-5218921
Signaling by SCF-KIT	REACTOME	R-HSA-1433557
Regulation of KIT signaling	REACTOME	R-HSA-1433559
Signaling by ERBB2	REACTOME	R-HSA-1227986
SHC1 events in ERBB2 signaling	REACTOME	R-HSA-1250196
Signaling by GPCR	REACTOME	R-HSA-372790
GPCR downstream signaling	REACTOME	R-HSA-388396
G alpha (z) signalling events	REACTOME	R-HSA-418597
Opioid Signalling	REACTOME	R-HSA-111885
G-protein mediated events	REACTOME	R-HSA-112040
PLC beta mediated events	REACTOME	R-HSA-112043
Ca-dependent events	REACTOME	R-HSA-111996
Gastrin-CREB signalling pathway via PKC and MAPK	REACTOME	R-HSA-881907
EGFR Transactivation by Gastrin	REACTOME	R-HSA-2179392
Signaling by Wnt	REACTOME	R-HSA-195721
Beta-catenin independent WNT signaling	REACTOME	R-HSA-3858494
PCP/CE pathway	REACTOME	R-HSA-4086400
WNT5A-dependent internalization of FZD4	REACTOME	R-HSA-5099900
Ca2+ pathway	REACTOME	R-HSA-4086398
Visual phototransduction	REACTOME	R-HSA-2187338
The phototransduction cascade	REACTOME	R-HSA-2514856
Inactivation, recovery and regulation of the phototransduction cascade	REACTOME	R-HSA-2514859
Gene Expression	REACTOME	R-HSA-74160
Regulation of mRNA stability by proteins that bind AU-rich elements	REACTOME	R-HSA-450531
HuR (ELAVL1) binds and stabilizes mRNA	REACTOME	R-HSA-450520
Cell Cycle	REACTOME	R-HSA-1640170
Cell Cycle, Mitotic	REACTOME	R-HSA-69278
M Phase	REACTOME	R-HSA-68886
Mitotic Prophase	REACTOME	R-HSA-68875
Nuclear Envelope Breakdown	REACTOME	R-HSA-2980766
Depolymerisation of the Nuclear Lamina	REACTOME	R-HSA-4419969
Metabolism	REACTOME	R-HSA-1430728
Integration of energy metabolism	REACTOME	R-HSA-163685
Regulation of insulin secretion	REACTOME	R-HSA-422356
Acetylcholine regulates insulin secretion	REACTOME	R-HSA-399997
Extracellular matrix organization	REACTOME	R-HSA-1474244
Non-integrin membrane-ECM interactions	REACTOME	R-HSA-3000171
Syndecan interactions	REACTOME	R-HSA-3000170
Developmental Biology	REACTOME	R-HSA-1266738
Axon guidance	REACTOME	R-HSA-422475
Aldosterone synthesis and secretion	KEGG	hsa04925
Aldosterone synthesis and secretion	KEGG	ko04925
Phospholipase D signaling pathway	KEGG	ko04072
Phospholipase D signaling pathway	KEGG	hsa04072
AGE-RAGE signaling pathway in diabetic complications	KEGG	ko04933
AGE-RAGE signaling pathway in diabetic complications	KEGG	hsa04933
EGFR tyrosine kinase inhibitor resistance	KEGG	ko01521
EGFR tyrosine kinase inhibitor resistance	KEGG	hsa01521
RET signaling	REACTOME	R-HSA-8853659

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PD	PMIDs
PA128394595	PLCH1	Gene	Pathway	associated
PA130232992	bevacizumab	Chemical	ClinicalAnnotation	associated	PD	29871907
PA134875646	PLCZ1	Gene	Pathway	associated
PA134914471	PLCH2	Gene	Pathway	associated
PA248	NFKB1	Gene	Pathway	associated
PA27749	ELK1	Gene	Pathway	associated
PA28212	FOS	Gene	Pathway	associated
PA296	RELA	Gene	Pathway	associated
PA30006	JUN	Gene	Pathway	associated
PA31353	MYC	Gene	Pathway	associated
PA31600	NFKB2	Gene	Pathway	associated
PA33384	PLCB1	Gene	Pathway	associated
PA33385	PLCB2	Gene	Pathway	associated
PA33386	PLCB3	Gene	Pathway	associated
PA33387	PLCB4	Gene	Pathway	associated
PA33388	PLCD1	Gene	Pathway	associated
PA33389	PLCD3	Gene	Pathway	associated
PA33390	PLCD4	Gene	Pathway	associated
PA33391	PLCE1	Gene	Pathway	associated
PA33392	PLCG1	Gene	Pathway	associated		20124951
PA33393	PLCG2	Gene	Pathway	associated		20124951
PA33394	PLCL1	Gene	Pathway	associated
PA33395	PLCL2	Gene	Pathway	associated
PA337	STAT3	Gene	Pathway	associated
PA338	STAT5A	Gene	Pathway	associated
PA34183	RAF1	Gene	Pathway	associated		20124951
PA36042	SP1	Gene	Pathway	associated
PA36183	STAT1	Gene	Pathway	associated
PA36184	STAT2	Gene	Pathway	associated
PA36185	STAT4	Gene	Pathway	associated
PA36186	STAT5B	Gene	Pathway	associated
PA39	ADRB2	Gene	Pathway	associated
PA444552	Hypertension	Disease	ClinicalAnnotation	associated	PD	29871907
PA449899	hydrochlorothiazide	Chemical	ClinicalAnnotation	associated	PD

References

Pubmed ID	Year	Title	Citations
38164042	2024	Cav-1 regulates the bile salt export pump on the canalicular membrane of hepatocytes by PKCα-associated signalling under cholesterol stimulation.	1
38815861	2024	Multi-modal mechanisms of the metastasis suppressor, NDRG1: Inhibition of WNT/β-catenin signaling by stabilization of protein kinase Cα.	0
38164042	2024	Cav-1 regulates the bile salt export pump on the canalicular membrane of hepatocytes by PKCα-associated signalling under cholesterol stimulation.	1
38815861	2024	Multi-modal mechanisms of the metastasis suppressor, NDRG1: Inhibition of WNT/β-catenin signaling by stabilization of protein kinase Cα.	0
36478369	2023	PKCα interacts with Ca(v) 1.3 calcium channels to promote the Ca(v) 1.2/Ca(v) 1.3 duo tuning Th2 functions.	0
36648303	2023	Protein Kinase C Modulation Determines the Mesoderm/Extraembryonic Fate Under BMP4 Induction From Human Pluripotent Stem Cells.	1
36791912	2023	Crosstalk between protein kinase C α and transforming growth factor β signaling mediated by Runx2 in intestinal epithelial cells.	1
36979484	2023	Spatiotemporal Regulation of FMNL2 by N-Terminal Myristoylation and C-Terminal Phosphorylation Drives Rapid Filopodia Formation.	2
37463241	2023	Histone Methyltransferase NSD2 Activates PKCα to Drive Metabolic Reprogramming and Lenalidomide Resistance in Multiple Myeloma.	0
36478369	2023	PKCα interacts with Ca(v) 1.3 calcium channels to promote the Ca(v) 1.2/Ca(v) 1.3 duo tuning Th2 functions.	0
36648303	2023	Protein Kinase C Modulation Determines the Mesoderm/Extraembryonic Fate Under BMP4 Induction From Human Pluripotent Stem Cells.	1
36791912	2023	Crosstalk between protein kinase C α and transforming growth factor β signaling mediated by Runx2 in intestinal epithelial cells.	1
36979484	2023	Spatiotemporal Regulation of FMNL2 by N-Terminal Myristoylation and C-Terminal Phosphorylation Drives Rapid Filopodia Formation.	2
37463241	2023	Histone Methyltransferase NSD2 Activates PKCα to Drive Metabolic Reprogramming and Lenalidomide Resistance in Multiple Myeloma.	0
34825477	2022	Gene-gene interactions in the protein kinase C/endothelial nitric oxide synthase axis impact the hypotensive effects of propofol.	1

Citation

Dessen P

PRKCA (protein kinase C alpha)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/41851/prkca-(protein-kinase-c-alpha)