ZMYND8 (zinc finger MYND-type containing 8)

2003-08-01  

Identity

HGNC
LOCATION
20q13.12
LOCUSID
ALIAS
PRKCBP1,PRO2893,RACK7
FUSION GENES

Other Information

Locus ID:

NCBI: 23613
MIM: 615713
HGNC: 9397
Ensembl: ENSG00000101040

Variants:

dbSNP: 23613
ClinVar: 23613
TCGA: ENSG00000101040
COSMIC: ZMYND8

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000101040ENST00000262975Q9ULU4
ENSG00000101040ENST00000311275Q9ULU4
ENSG00000101040ENST00000352431Q9ULU4
ENSG00000101040ENST00000355972Q9ULU4
ENSG00000101040ENST00000360911Q9ULU4
ENSG00000101040ENST00000372023Q9ULU4
ENSG00000101040ENST00000396281Q9ULU4
ENSG00000101040ENST00000435836Q5TH12
ENSG00000101040ENST00000441977Q5TH07
ENSG00000101040ENST00000446894Q5TH08
ENSG00000101040ENST00000446994Q9ULU4
ENSG00000101040ENST00000458360Q9ULU4
ENSG00000101040ENST00000461685Q9ULU4
ENSG00000101040ENST00000467200H7C4X9
ENSG00000101040ENST00000471951Q9ULU4
ENSG00000101040ENST00000536340Q9ULU4
ENSG00000101040ENST00000540497Q9ULU4
ENSG00000101040ENST00000611941A0A087WYS3
ENSG00000101040ENST00000617418A0A087WVZ6
ENSG00000101040ENST00000619049A0A087WV57

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
359168662022De Novo ZMYND8 variants result in an autosomal dominant neurodevelopmental disorder with cardiac malformations.1
359168662022De Novo ZMYND8 variants result in an autosomal dominant neurodevelopmental disorder with cardiac malformations.1
331486602021ZMYND8 Expression in Breast Cancer Cells Blocks T-Lymphocyte Surveillance to Promote Tumor Growth.9
335939122021ZMYND8 preferentially binds phosphorylated EZH2 to promote a PRC2-dependent to -independent function switch in hypoxia-inducible factor-activated cancer.11
343584472021ZMYND8-regulated IRF8 transcription axis is an acute myeloid leukemia dependency.19
344627842021Validation of ZMYND8 as a new treatment target in hepatocellular carcinoma.2
331486602021ZMYND8 Expression in Breast Cancer Cells Blocks T-Lymphocyte Surveillance to Promote Tumor Growth.9
335939122021ZMYND8 preferentially binds phosphorylated EZH2 to promote a PRC2-dependent to -independent function switch in hypoxia-inducible factor-activated cancer.11
343584472021ZMYND8-regulated IRF8 transcription axis is an acute myeloid leukemia dependency.19
344627842021Validation of ZMYND8 as a new treatment target in hepatocellular carcinoma.2
319659802020A novel role of tumor suppressor ZMYND8 in inducing differentiation of breast cancer cells through its dual-histone binding function.3
322245272020ZMYND8 expression combined with pN and pM classification as a novel prognostic prediction model for colorectal cancer: Based on TCGA and GEO database analysis.7
328326242020RACK7 recognizes H3.3G34R mutation to suppress expression of MHC class II complex components and their delivery pathway in pediatric glioblastoma.16
333239282020Suppression of poised oncogenes by ZMYND8 promotes chemo-sensitization.9
319659802020A novel role of tumor suppressor ZMYND8 in inducing differentiation of breast cancer cells through its dual-histone binding function.3

Citation

Dessen P

ZMYND8 (zinc finger MYND-type containing 8)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/41853/deep-insight-explorer/gene-explorer/humanGenome