PRKCE (protein kinase C epsilon)

2003-02-01 Affiliation

Identity

HGNC

PRKCE

LOCATION

2p21

LOCUSID

5581

ALIAS

PKCE,nPKC-epsilon

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 5581
MIM: 176975
HGNC: 9401
Ensembl: ENSG00000171132

Variants:

dbSNP: 5581
ClinVar: 5581
TCGA: ENSG00000171132
COSMIC: PRKCE

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000171132	ENST00000306156	Q02156
ENSG00000171132	ENST00000306156	L7RTI5
ENSG00000171132	ENST00000394874	E9PBI2
ENSG00000171132	ENST00000421201	C9JR22

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Tight junction	KEGG	ko04530
Type II diabetes mellitus	KEGG	ko04930
Tight junction	KEGG	hsa04530
Type II diabetes mellitus	KEGG	hsa04930
Vascular smooth muscle contraction	KEGG	hsa04270
Vascular smooth muscle contraction	KEGG	ko04270
Fc gamma R-mediated phagocytosis	KEGG	ko04666
Fc gamma R-mediated phagocytosis	KEGG	hsa04666
MicroRNAs in cancer	KEGG	hsa05206
MicroRNAs in cancer	KEGG	ko05206
Inflammatory mediator regulation of TRP channels	KEGG	hsa04750
Inflammatory mediator regulation of TRP channels	KEGG	ko04750
cGMP-PKG signaling pathway	KEGG	hsa04022
cGMP-PKG signaling pathway	KEGG	ko04022
Sphingolipid signaling pathway	KEGG	hsa04071
Sphingolipid signaling pathway	KEGG	ko04071
Immune System	REACTOME	R-HSA-168256
Innate Immune System	REACTOME	R-HSA-168249
Fcgamma receptor (FCGR) dependent phagocytosis	REACTOME	R-HSA-2029480
Role of phospholipids in phagocytosis	REACTOME	R-HSA-2029485
DAP12 interactions	REACTOME	R-HSA-2172127
DAP12 signaling	REACTOME	R-HSA-2424491
DAG and IP3 signaling	REACTOME	R-HSA-1489509
Hemostasis	REACTOME	R-HSA-109582
Platelet activation, signaling and aggregation	REACTOME	R-HSA-76002
Effects of PIP2 hydrolysis	REACTOME	R-HSA-114508
Signal Transduction	REACTOME	R-HSA-162582
Signaling by EGFR	REACTOME	R-HSA-177929
EGFR interacts with phospholipase C-gamma	REACTOME	R-HSA-212718
Signalling by NGF	REACTOME	R-HSA-166520
NGF signalling via TRKA from the plasma membrane	REACTOME	R-HSA-187037
PLC-gamma1 signalling	REACTOME	R-HSA-167021
Signaling by PDGF	REACTOME	R-HSA-186797
Downstream signal transduction	REACTOME	R-HSA-186763
Signaling by ERBB2	REACTOME	R-HSA-1227986
SHC1 events in ERBB2 signaling	REACTOME	R-HSA-1250196
Signaling by GPCR	REACTOME	R-HSA-372790
GPCR downstream signaling	REACTOME	R-HSA-388396
G alpha (z) signalling events	REACTOME	R-HSA-418597
G alpha (q) signalling events	REACTOME	R-HSA-416476
Gastrin-CREB signalling pathway via PKC and MAPK	REACTOME	R-HSA-881907
Aldosterone synthesis and secretion	KEGG	hsa04925
Insulin resistance	KEGG	hsa04931
Aldosterone synthesis and secretion	KEGG	ko04925
AGE-RAGE signaling pathway in diabetic complications	KEGG	ko04933
AGE-RAGE signaling pathway in diabetic complications	KEGG	hsa04933
Apelin signaling pathway	KEGG	hsa04371

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PD	PMIDs
PA166122986	radiotherapy	Chemical	ClinicalAnnotation	associated	PD	25054431
PA33392	PLCG1	Gene	Pathway	associated		20124951
PA33393	PLCG2	Gene	Pathway	associated		20124951
PA34183	RAF1	Gene	Pathway	associated		20124951
PA39	ADRB2	Gene	Pathway	associated
PA62	ATP1A1	Gene	Pathway	associated		23788015

References

Pubmed ID	Year	Title	Citations
38656553	2024	The binding of PKCε and MEG2 to STAT3 regulates IL-6-mediated microglial hyperalgesia during inflammatory pain.	0
38656553	2024	The binding of PKCε and MEG2 to STAT3 regulates IL-6-mediated microglial hyperalgesia during inflammatory pain.	0
36400183	2023	Protein kinase C epsilon promotes de novo lipogenesis and tumor growth in prostate cancer cells by regulating the phosphorylation and nuclear translocation of pyruvate kinase isoform M2.	1
36782184	2023	Elucidating the role of missense SNP of protein kinase C epsilon in HCV-induced hepatocellular carcinoma.	1
37336366	2023	Apolipoprotein E ε4 triggers neurotoxicity via cholesterol accumulation, acetylcholine dyshomeostasis, and PKCε mislocalization in cholinergic neuronal cells.	3
37501577	2023	Effects of PKCε knockdown on mitochondrial membrane potential of human glioma cells in vitro and growth of U251 cell-derived tumors in vivo.	0
37833790	2023	Cross talk of tumor protein D52 (TPD52) with KLF9, PKCε, and MicroRNA 223 in ovarian cancer.	1
36400183	2023	Protein kinase C epsilon promotes de novo lipogenesis and tumor growth in prostate cancer cells by regulating the phosphorylation and nuclear translocation of pyruvate kinase isoform M2.	1
36782184	2023	Elucidating the role of missense SNP of protein kinase C epsilon in HCV-induced hepatocellular carcinoma.	1
37336366	2023	Apolipoprotein E ε4 triggers neurotoxicity via cholesterol accumulation, acetylcholine dyshomeostasis, and PKCε mislocalization in cholinergic neuronal cells.	3
37501577	2023	Effects of PKCε knockdown on mitochondrial membrane potential of human glioma cells in vitro and growth of U251 cell-derived tumors in vivo.	0
37833790	2023	Cross talk of tumor protein D52 (TPD52) with KLF9, PKCε, and MicroRNA 223 in ovarian cancer.	1
34108094	2022	Genome-wide DNA methylation profiling in nonalcoholic fatty liver reveals predictive aberrant methylation in PRKCE and SEC14L3 promoters.	5
34108094	2022	Genome-wide DNA methylation profiling in nonalcoholic fatty liver reveals predictive aberrant methylation in PRKCE and SEC14L3 promoters.	5
31648598	2021	PKCε regulates Rho GTPases and actin cytoskeleton reorganization in non-small cell lung cancer cells.	8

Citation

Dessen P

PRKCE (protein kinase C epsilon)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/41855/prkce-(protein-kinase-c-epsilon)