PRKCQ (protein kinase C theta)

2003-11-01  

Identity

HGNC
PRKCQ
LOCATION
10p15.1
LOCUSID
5588
ALIAS
PRKCT,nPKC-theta
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 5588
MIM: 600448
HGNC: 9410
Ensembl: ENSG00000065675

Variants:

dbSNP: 5588
ClinVar: 5588
TCGA: ENSG00000065675
COSMIC: PRKCQ

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000065675ENST00000263125Q04759
ENSG00000065675ENST00000397176Q04759
ENSG00000065675ENST00000539722Q04759
ENSG00000065675ENST00000610727A0A087X0I9

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Autophagy - animalKEGGko04140
T cell receptor signaling pathwayKEGGko04660
Adipocytokine signaling pathwayKEGGko04920
Autophagy - animalKEGGhsa04140
T cell receptor signaling pathwayKEGGhsa04660
Adipocytokine signaling pathwayKEGGhsa04920
Vascular smooth muscle contractionKEGGhsa04270
Vascular smooth muscle contractionKEGGko04270
MeaslesKEGGko05162
MeaslesKEGGhsa05162
NF-kappa B signaling pathwayKEGGhsa04064
NF-kappa B signaling pathwayKEGGko04064
Inflammatory mediator regulation of TRP channelsKEGGhsa04750
Inflammatory mediator regulation of TRP channelsKEGGko04750
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
TCR signalingREACTOMER-HSA-202403
Downstream TCR signalingREACTOMER-HSA-202424
Innate Immune SystemREACTOMER-HSA-168249
Fc epsilon receptor (FCERI) signalingREACTOMER-HSA-2454202
FCERI mediated NF-kB activationREACTOMER-HSA-2871837
HemostasisREACTOMER-HSA-109582
Platelet activation, signaling and aggregationREACTOMER-HSA-76002
Effects of PIP2 hydrolysisREACTOMER-HSA-114508
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (z) signalling eventsREACTOMER-HSA-418597
G alpha (q) signalling eventsREACTOMER-HSA-416476
Gastrin-CREB signalling pathway via PKC and MAPKREACTOMER-HSA-881907
Visual phototransductionREACTOMER-HSA-2187338
The phototransduction cascadeREACTOMER-HSA-2514856
Inactivation, recovery and regulation of the phototransduction cascadeREACTOMER-HSA-2514859
Programmed Cell DeathREACTOMER-HSA-5357801
ApoptosisREACTOMER-HSA-109581
Apoptotic execution phaseREACTOMER-HSA-75153
Apoptotic cleavage of cellular proteinsREACTOMER-HSA-111465
Developmental BiologyREACTOMER-HSA-1266738
Axon guidanceREACTOMER-HSA-422475
Netrin-1 signalingREACTOMER-HSA-373752
Insulin resistanceKEGGhsa04931
Th1 and Th2 cell differentiationKEGGko04658
Th1 and Th2 cell differentiationKEGGhsa04658
Th17 cell differentiationKEGGko04659
Th17 cell differentiationKEGGhsa04659

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA33392PLCG1GenePathwayassociated20124951
PA33393PLCG2GenePathwayassociated20124951
PA34183RAF1GenePathwayassociated20124951
PA39ADRB2GenePathwayassociated

References

Pubmed IDYearTitleCitations
385131402024PD1 inhibits PKCθ-dependent phosphorylation of cytoskeleton-related proteins and immune synapse formation.0
385131402024PD1 inhibits PKCθ-dependent phosphorylation of cytoskeleton-related proteins and immune synapse formation.0
369692362023The Peptidyl-Prolyl cis-trans isomerase, Pin1, associates with Protein Kinase C θ via a critical Phospho-Thr-Pro motif in the V3 regulatory domain.0
369692362023The Peptidyl-Prolyl cis-trans isomerase, Pin1, associates with Protein Kinase C θ via a critical Phospho-Thr-Pro motif in the V3 regulatory domain.0
354475302022Crocin attenuates NF-κB-mediated inflammation and proliferation in breast cancer cells by down-regulating PRKCQ.6
354475302022Crocin attenuates NF-κB-mediated inflammation and proliferation in breast cancer cells by down-regulating PRKCQ.6
335625062021The Emerging Function of PKCtheta in Cancer.13
335760062021Crosstalk between miR-203 and PKCθ regulates breast cancer stem cell markers.2
335625062021The Emerging Function of PKCtheta in Cancer.13
335760062021Crosstalk between miR-203 and PKCθ regulates breast cancer stem cell markers.2
322393982020Two novel pleiotropic loci associated with osteoporosis and abdominal obesity.5
323820402020PKCθ-JunB axis via upregulation of VEGFR3 expression mediates hypoxia-induced pathological retinal neovascularization.9
326004442020PRKCQ inhibition enhances chemosensitivity of triple-negative breast cancer by regulating Bim.10
327960342020Annexin A5 is essential for PKCθ translocation during T-cell activation.4
322393982020Two novel pleiotropic loci associated with osteoporosis and abdominal obesity.5

Citation

Dessen P

PRKCQ (protein kinase C theta)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/41861/prkcq-(protein-kinase-c-theta)