Identity
HGNC
LOCATION
10p15.1
LOCUSID
ALIAS
PRKCT,nPKC-theta
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 5588
MIM: 600448
HGNC: 9410
Ensembl: ENSG00000065675
Variants:
dbSNP: 5588
ClinVar: 5588
TCGA: ENSG00000065675
COSMIC: PRKCQ
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000065675 | ENST00000263125 | Q04759 |
| ENSG00000065675 | ENST00000397176 | Q04759 |
| ENSG00000065675 | ENST00000539722 | Q04759 |
| ENSG00000065675 | ENST00000610727 | A0A087X0I9 |
Expression (GTEx)
Pathways
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA33392 | PLCG1 | Gene | Pathway | associated | 20124951 | ||
| PA33393 | PLCG2 | Gene | Pathway | associated | 20124951 | ||
| PA34183 | RAF1 | Gene | Pathway | associated | 20124951 | ||
| PA39 | ADRB2 | Gene | Pathway | associated |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38513140 | 2024 | PD1 inhibits PKCθ-dependent phosphorylation of cytoskeleton-related proteins and immune synapse formation. | 0 |
| 38513140 | 2024 | PD1 inhibits PKCθ-dependent phosphorylation of cytoskeleton-related proteins and immune synapse formation. | 0 |
| 36969236 | 2023 | The Peptidyl-Prolyl cis-trans isomerase, Pin1, associates with Protein Kinase C θ via a critical Phospho-Thr-Pro motif in the V3 regulatory domain. | 0 |
| 36969236 | 2023 | The Peptidyl-Prolyl cis-trans isomerase, Pin1, associates with Protein Kinase C θ via a critical Phospho-Thr-Pro motif in the V3 regulatory domain. | 0 |
| 35447530 | 2022 | Crocin attenuates NF-κB-mediated inflammation and proliferation in breast cancer cells by down-regulating PRKCQ. | 6 |
| 35447530 | 2022 | Crocin attenuates NF-κB-mediated inflammation and proliferation in breast cancer cells by down-regulating PRKCQ. | 6 |
| 33562506 | 2021 | The Emerging Function of PKCtheta in Cancer. | 13 |
| 33576006 | 2021 | Crosstalk between miR-203 and PKCθ regulates breast cancer stem cell markers. | 2 |
| 33562506 | 2021 | The Emerging Function of PKCtheta in Cancer. | 13 |
| 33576006 | 2021 | Crosstalk between miR-203 and PKCθ regulates breast cancer stem cell markers. | 2 |
| 32239398 | 2020 | Two novel pleiotropic loci associated with osteoporosis and abdominal obesity. | 5 |
| 32382040 | 2020 | PKCθ-JunB axis via upregulation of VEGFR3 expression mediates hypoxia-induced pathological retinal neovascularization. | 9 |
| 32600444 | 2020 | PRKCQ inhibition enhances chemosensitivity of triple-negative breast cancer by regulating Bim. | 10 |
| 32796034 | 2020 | Annexin A5 is essential for PKCθ translocation during T-cell activation. | 4 |
| 32239398 | 2020 | Two novel pleiotropic loci associated with osteoporosis and abdominal obesity. | 5 |
Citation
Dessen P
PRKCQ (protein kinase C theta)
Atlas Genet Cytogenet Oncol Haematol. 2003-11-01
Online version: http://atlasgeneticsoncology.org/gene/41861/prkcq-(protein-kinase-c-theta)
