PRODH (proline dehydrogenase 1)

2003-02-01  

Identity

HGNC
LOCATION
22q11.21
LOCUSID
ALIAS
HSPOX2,PIG6,POX,PRODH1,PRODH2,TP53I6
FUSION GENES

Other Information

Locus ID:

NCBI: 5625
MIM: 606810
HGNC: 9453
Ensembl: ENSG00000100033

Variants:

dbSNP: 5625
ClinVar: 5625
TCGA: ENSG00000100033
COSMIC: PRODH

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000100033ENST00000334029E7EQL6
ENSG00000100033ENST00000357068O43272
ENSG00000100033ENST00000420436E7EQL6
ENSG00000100033ENST00000438924H7C363
ENSG00000100033ENST00000450579C9JIW4
ENSG00000100033ENST00000457083H7C3U9
ENSG00000100033ENST00000610940A0A087WWM6

Expression (GTEx)

0
10
20
30
40
50
60
70

Pathways

PathwaySourceExternal ID
Arginine and proline metabolismKEGGko00330
Arginine and proline metabolismKEGGhsa00330
Metabolic pathwaysKEGGhsa01100
MetabolismREACTOMER-HSA-1430728
Metabolism of amino acids and derivativesREACTOMER-HSA-71291
Proline catabolismREACTOMER-HSA-70688
Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolismREACTOMER-HSA-6788656

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
185839792008Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the SzGene database.395
197363512009Recurrent rearrangements in synaptic and neurodevelopmental genes and shared biologic pathways in schizophrenia, autism, and mental retardation.151
166190342006Proline oxidase activates both intrinsic and extrinsic pathways for apoptosis: the role of ROS/superoxides, NFAT and MEK/ERK signaling.59
171352752007Involvement of hyperprolinemia in cognitive and psychiatric features of the 22q11 deletion syndrome.54
205629152010miR-23b targets proline oxidase, a novel tumor suppressor protein in renal cancer.51
122179522002PRODH mutations and hyperprolinemia in a subset of schizophrenic patients.50
210416082011Family-based analysis of genetic variation underlying psychosis-inducing effects of cannabis: sibling analysis and proband follow-up.48
214482372011Reduced transcript expression of genes affected by inherited and de novo CNVs in autism.48
154499432004Structures of the Escherichia coli PutA proline dehydrogenase domain in complex with competitive inhibitors.45
159144622005The p53-induced gene-6 (proline oxidase) mediates apoptosis through a calcineurin-dependent pathway.45

Citation

Dessen P

PRODH (proline dehydrogenase 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/41873/prodh-(proline-dehydrogenase-1)