PROM1 (prominin 1)

2003-12-01  

Identity

HGNC
PROM1
LOCATION
4p15.32
LOCUSID
8842
ALIAS
AC133,CD133,CORD12,MCDR2,MSTP061,PROML1,RP41,STGD4
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 8842
MIM: 604365
HGNC: 9454
Ensembl: ENSG00000007062

Variants:

dbSNP: 8842
ClinVar: 8842
TCGA: ENSG00000007062
COSMIC: PROM1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000007062ENST00000447510O43490
ENSG00000007062ENST00000503884H0Y9D4
ENSG00000007062ENST00000505450O43490
ENSG00000007062ENST00000505450A0A0A0N0M1
ENSG00000007062ENST00000508167O43490
ENSG00000007062ENST00000508167A0A0A0N0M1
ENSG00000007062ENST00000508322D6RIF3
ENSG00000007062ENST00000508940D6RBI0
ENSG00000007062ENST00000510224O43490
ENSG00000007062ENST00000511153H0Y9M7
ENSG00000007062ENST00000513946H0Y9Q5
ENSG00000007062ENST00000514967D6RCC3
ENSG00000007062ENST00000539194O43490
ENSG00000007062ENST00000540805O43490

Expression (GTEx)

0
10
20
30
40
50
60
70
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Transcriptional misregulation in cancerKEGGko05202
Transcriptional misregulation in cancerKEGGhsa05202

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
171227722007A human colon cancer cell capable of initiating tumour growth in immunodeficient mice.1306
198052942009Highly tumorigenic lung cancer CD133+ cells display stem-like features and are spared by cisplatin treatment.290
199048292010NOTCH pathway blockade depletes CD133-positive glioblastoma cells and inhibits growth of tumor neurospheres and xenografts.241
152263772004CD133, a novel marker for human prostatic epithelial stem cells.222
181722612008Stem cell marker CD133 affects clinical outcome in glioma patients.194
186449792008Aldehyde dehydrogenase discriminates the CD133 liver cancer stem cell populations.182
172055162007CD133 positive hepatocellular carcinoma cells possess high capacity for tumorigenicity.172
198169572009CD133 expression defines a tumor initiating cell population in primary human ovarian cancer.167
188364862009Epigenetic regulation of CD133 and tumorigenicity of CD133+ ovarian cancer cells.157
216951882011ALDH activity selectively defines an enhanced tumor-initiating cell population relative to CD133 expression in human pancreatic adenocarcinoma.136

Citation

Dessen P

PROM1 (prominin 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-12-01

Online version: http://atlasgeneticsoncology.org/gene/41874/prom1-(prominin-1)