PTGS1 (prostaglandin-endoperoxide synthase 1)

2003-02-01 Affiliation

Identity

HGNC

PTGS1

LOCATION

9q33.2

LOCUSID

5742

ALIAS

COX1,COX3,PCOX1,PES-1,PGG/HS,PGHS-1,PGHS1,PHS1,PTGHS

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 5742
MIM: 176805
HGNC: 9604
Ensembl: ENSG00000095303

Variants:

dbSNP: 5742
ClinVar: 5742
TCGA: ENSG00000095303
COSMIC: PTGS1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000095303	ENST00000223423	P23219
ENSG00000095303	ENST00000362012	P23219
ENSG00000095303	ENST00000373698	P23219
ENSG00000095303	ENST00000426608	X6RJD6
ENSG00000095303	ENST00000540753	P23219
ENSG00000095303	ENST00000619306	A0A087X296
ENSG00000095303	ENST00000643810	A0A2R8YDM0
ENSG00000095303	ENST00000647067	A0A2R8Y6S0

Expression (GTEx)

100

150

200

250

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Arachidonic acid metabolism	KEGG	ko00590
Arachidonic acid metabolism	KEGG	hsa00590
Metabolic pathways	KEGG	hsa01100
Serotonergic synapse	KEGG	hsa04726
Platelet activation	KEGG	hsa04611
Regulation of lipolysis in adipocytes	KEGG	hsa04923
Metabolism	REACTOME	R-HSA-1430728
Metabolism of lipids and lipoproteins	REACTOME	R-HSA-556833
Arachidonic acid metabolism	REACTOME	R-HSA-2142753
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)	REACTOME	R-HSA-2162123
Biological oxidations	REACTOME	R-HSA-211859
Phase 1 - Functionalization of compounds	REACTOME	R-HSA-211945
COX reactions	REACTOME	R-HSA-140180

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PD	PMIDs
PA10384	antiinflammatory and antirheumatic products, non-steroids	Chemical	Pathway	associated		22336956
PA164712462	Antiinflammatory agents, non-steroids	Chemical	ClinicalAnnotation	associated	PD	20538124
PA164774763	latanoprost	Chemical	ClinicalAnnotation	associated	PD	25339146
PA165108401	Acute coronary syndrome	Disease	ClinicalAnnotation	associated	PD	20538124
PA166129560	major adverse cardiac events (mace)	Disease	ClinicalAnnotation	associated	PD
PA443796	Coronary Artery Disease	Disease	ClinicalAnnotation	associated	PD	16493486, 22940005
PA444282	Glaucoma, Open-Angle	Disease	ClinicalAnnotation	associated	PD	25339146
PA445019	Myocardial Infarction	Disease	ClinicalAnnotation	associated	PD	16493486, 22940005
PA448497	aspirin	Chemical	ClinicalAnnotation, Pathway	associated	PD	16493486, 20938371, 22940005
PA449053	clopidogrel	Chemical	ClinicalAnnotation	associated	PD	22940005
PA449957	ibuprofen	Chemical	Pathway	associated		25502615

References

Pubmed ID	Year	Title	Citations
36056535	2023	The PTGS1 (rs1330344) CC Genotype Contributes to Susceptibility to Kawasaki Disease in Southern Chinese Children.	2
36282419	2023	EVI1 upregulates PTGS1 (COX1) and decreases the action of tyrosine kinase inhibitors (TKIs) in chronic myeloid leukemia cells.	1
36056535	2023	The PTGS1 (rs1330344) CC Genotype Contributes to Susceptibility to Kawasaki Disease in Southern Chinese Children.	2
36282419	2023	EVI1 upregulates PTGS1 (COX1) and decreases the action of tyrosine kinase inhibitors (TKIs) in chronic myeloid leukemia cells.	1
35000048	2022	COX-1, COX-2 and CYP2C19 variations may be related to cardiovascular events due to acetylsalicylic acid resistance.	1
35631221	2022	Association between Vitamin Intake and Chronic Kidney Disease According to a Variant Located Upstream of the PTGS1 Gene: A Cross-Sectional Analysis of Shika Study.	1
35705023	2022	Effect of CYP2C9, PTGS-1 and PTGS-2 gene polymorphisms on the efficiency and safety of postoperative analgesia with ketoprofen.	0
36302763	2022	Human mtRF1 terminates COX1 translation and its ablation induces mitochondrial ribosome-associated quality control.	4
35000048	2022	COX-1, COX-2 and CYP2C19 variations may be related to cardiovascular events due to acetylsalicylic acid resistance.	1
35631221	2022	Association between Vitamin Intake and Chronic Kidney Disease According to a Variant Located Upstream of the PTGS1 Gene: A Cross-Sectional Analysis of Shika Study.	1
35705023	2022	Effect of CYP2C9, PTGS-1 and PTGS-2 gene polymorphisms on the efficiency and safety of postoperative analgesia with ketoprofen.	0
36302763	2022	Human mtRF1 terminates COX1 translation and its ablation induces mitochondrial ribosome-associated quality control.	4
32299908	2021	Identification of a homozygous recessive variant in PTGS1 resulting in a congenital aspirin-like defect in platelet function.	5
32584621	2021	PTGS1 gene variations associated with bleeding and platelet dysfunction.	5
33326144	2021	A novel genetic variant in PTGS1 affects N-glycosylation of cyclooxygenase-1 causing a dominant-negative effect on platelet function and bleeding diathesis.	2

Citation

Dessen P

PTGS1 (prostaglandin-endoperoxide synthase 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/41896/ptgs1-(prostaglandin-endoperoxide-synthase-1)