PTK2B (protein tyrosine kinase 2 beta)

2003-11-01  

Identity

HGNC
PTK2B
LOCATION
8p21.2
LOCUSID
2185
ALIAS
CADTK,CAKB,FADK2,FAK2,PKB,PTK,PYK2,RAFTK
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 2185
MIM: 601212
HGNC: 9612
Ensembl: ENSG00000120899

Variants:

dbSNP: 2185
ClinVar: 2185
TCGA: ENSG00000120899
COSMIC: PTK2B

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000120899ENST00000346049Q14289
ENSG00000120899ENST00000397501Q14289
ENSG00000120899ENST00000412793C9JHV9
ENSG00000120899ENST00000420218Q14289
ENSG00000120899ENST00000517339Q14289
ENSG00000120899ENST00000519512H0YB74
ENSG00000120899ENST00000521164E5RK84
ENSG00000120899ENST00000522338E5RHL2
ENSG00000120899ENST00000522517E5RJ77

Expression (GTEx)

0
50
100
150
200
250
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Calcium signaling pathwayKEGGko04020
Natural killer cell mediated cytotoxicityKEGGko04650
Leukocyte transendothelial migrationKEGGko04670
GnRH signaling pathwayKEGGko04912
Calcium signaling pathwayKEGGhsa04020
Natural killer cell mediated cytotoxicityKEGGhsa04650
Leukocyte transendothelial migrationKEGGhsa04670
GnRH signaling pathwayKEGGhsa04912
Chemokine signaling pathwayKEGGko04062
Chemokine signaling pathwayKEGGhsa04062
Hepatitis BKEGGhsa05161
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Signaling by InterleukinsREACTOMER-HSA-449147
Interleukin-2 signalingREACTOMER-HSA-451927
Signal TransductionREACTOMER-HSA-162582
Signaling by VEGFREACTOMER-HSA-194138
VEGFA-VEGFR2 PathwayREACTOMER-HSA-4420097
Cell-Cell communicationREACTOMER-HSA-1500931
Signal regulatory protein (SIRP) family interactionsREACTOMER-HSA-391160
Phospholipase D signaling pathwayKEGGko04072
Phospholipase D signaling pathwayKEGGhsa04072

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
375869822024PYK2, a hub of signaling networks in breast cancer progression.3
375869822024PYK2, a hub of signaling networks in breast cancer progression.3
364704812023Wide-spread enhancer effect of SNP rs2279590 on regulating epoxide hydrolase-2 and protein tyrosine kinase 2-beta gene expression.2
370988082023The role and molecular mechanism of metabolic reprogramming of colorectal cancer by UBR5 through PYK2 regulation of OXPHOS expression study.1
372691552023PTK2B regulates immune responses of neutrophils and protects mucosal inflammation in ulcerative colitis.3
374878772023The regulation of human organic anion transporter 4 by insulin-like growth factor 1 and protein kinase B signaling.1
378948112023Thrombin-Induced COX-2 Expression and PGE(2) Synthesis in Human Tracheal Smooth Muscle Cells: Role of PKCδ/Pyk2-Dependent AP-1 Pathway Modulation.1
383218952023Microglia PTK2B/Pyk2 in the Pathogenesis of Alzheimer's Disease.1
364704812023Wide-spread enhancer effect of SNP rs2279590 on regulating epoxide hydrolase-2 and protein tyrosine kinase 2-beta gene expression.2
370988082023The role and molecular mechanism of metabolic reprogramming of colorectal cancer by UBR5 through PYK2 regulation of OXPHOS expression study.1
372691552023PTK2B regulates immune responses of neutrophils and protects mucosal inflammation in ulcerative colitis.3
374878772023The regulation of human organic anion transporter 4 by insulin-like growth factor 1 and protein kinase B signaling.1
378948112023Thrombin-Induced COX-2 Expression and PGE(2) Synthesis in Human Tracheal Smooth Muscle Cells: Role of PKCδ/Pyk2-Dependent AP-1 Pathway Modulation.1
383218952023Microglia PTK2B/Pyk2 in the Pathogenesis of Alzheimer's Disease.1
349056572022Role of proline-rich tyrosine kinase 2 (Pyk2) in the pathogenesis of Alzheimer's disease.0

Citation

Dessen P

PTK2B (protein tyrosine kinase 2 beta)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/41899