PTP4A1 (protein tyrosine phosphatase 4A1)

2003-02-01  

Identity

HGNC
PTP4A1
LOCATION
6q12
LOCUSID
7803
ALIAS
HH72,PRL-1,PRL1,PTP(CAAX1),PTPCAAX1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 7803
MIM: 601585
HGNC: 9634
Ensembl: ENSG00000112245

Variants:

dbSNP: 7803
ClinVar: 7803
TCGA: ENSG00000112245
COSMIC: PTP4A1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000112245ENST00000626021Q93096
ENSG00000112245ENST00000626021A0A024R8J2
ENSG00000112245ENST00000627002A0A0D9SGK2
ENSG00000112245ENST00000639568A0A3B3ISR8
ENSG00000112245ENST00000648894Q93096
ENSG00000112245ENST00000648894A0A024R8J2
ENSG00000112245ENST00000672924A0A024R8J2
ENSG00000112245ENST00000673199A0A024R8J2

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
224139912013Molecular mechanisms of the PRL phosphatases.47
191993802009PRL1 promotes cell migration and invasion by increasing MMP2 and MMP9 expression through Src and ERK1/2 pathways.45
122351452002The tyrosine phosphatase PRL-1 localizes to the endoplasmic reticulum and the mitotic spindle and is required for normal mitosis.38
168324102006Expression and prognostic impact of the protein tyrosine phosphatases PRL-1, PRL-2, and PRL-3 in breast cancer.37
146434502003Enhanced cell cycle progression and down regulation of p21(Cip1/Waf1) by PRL tyrosine phosphatases.29
206286242010Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot".29
220964942011A novel, functional and replicable risk gene region for alcohol dependence identified by genome-wide association study.29
155717312005Trimeric structure of PRL-1 phosphatase reveals an active enzyme conformation and regulation mechanisms.27
176563572007Phosphatase activity, trimerization, and the C-terminal polybasic region are all required for PRL1-mediated cell growth and migration.27
189978162009New p53 target, phosphatase of regenerating liver 1 (PRL-1) downregulates p53.19

Citation

Dessen P

PTP4A1 (protein tyrosine phosphatase 4A1)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/41906/ptp4a1-(protein-tyrosine-phosphatase-4a1)