PTP4A2 (protein tyrosine phosphatase 4A2)

2003-02-01  

Identity

HGNC
PTP4A2
LOCATION
1p35.2
LOCUSID
8073
ALIAS
HH13,HH7-2,HU-PP-1,OV-1,PRL-2,PRL2,PTP4A,PTPCAAX2,ptp-IV1a,ptp-IV1b
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 8073
MIM: 601584
HGNC: 9635
Ensembl: ENSG00000184007

Variants:

dbSNP: 8073
ClinVar: 8073
TCGA: ENSG00000184007
COSMIC: PTP4A2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000184007ENST00000457805Q12974
ENSG00000184007ENST00000468531E9PMY3
ENSG00000184007ENST00000470404E9PRR9
ENSG00000184007ENST00000528253E9PJC0
ENSG00000184007ENST00000532001E9PML8
ENSG00000184007ENST00000534796E9PL34
ENSG00000184007ENST00000602683Q12974
ENSG00000184007ENST00000602725Q12974
ENSG00000184007ENST00000626355E9PML8
ENSG00000184007ENST00000627328E9PJC0
ENSG00000184007ENST00000647444Q12974
ENSG00000184007ENST00000649841Q12974

Expression (GTEx)

0
50
100
150
200
250
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
RAB geranylgeranylationREACTOMER-HSA-8873719

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
327330842020A FRET-based screening method to detect potential inhibitors of the binding of CNNM3 to PRL2.4
327883642020Mechanism of PRL2 phosphatase-mediated PTEN degradation and tumorigenesis.17
327330842020A FRET-based screening method to detect potential inhibitors of the binding of CNNM3 to PRL2.4
327883642020Mechanism of PRL2 phosphatase-mediated PTEN degradation and tumorigenesis.17
307184342019Magnesium-sensitive upstream ORF controls PRL phosphatase expression to mediate energy metabolism.33
307184342019Magnesium-sensitive upstream ORF controls PRL phosphatase expression to mediate energy metabolism.33
278724992017Phosphatase PRL2 promotes oncogenic NOTCH1-Induced T-cell leukemia.8
282200382017Phosphatase PRL2 promotes AML1-ETO-induced acute myeloid leukemia.5
278724992017Phosphatase PRL2 promotes oncogenic NOTCH1-Induced T-cell leukemia.8
282200382017Phosphatase PRL2 promotes AML1-ETO-induced acute myeloid leukemia.5
251939862014MiR-29c mediates epithelial-to-mesenchymal transition in human colorectal carcinoma metastasis via PTP4A and GNA13 regulation of β-catenin signaling.54
251939862014MiR-29c mediates epithelial-to-mesenchymal transition in human colorectal carcinoma metastasis via PTP4A and GNA13 regulation of β-catenin signaling.54
224139912013Molecular mechanisms of the PRL phosphatases.65
233622752013Thioredoxin-related protein 32 (TRP32) specifically reduces oxidized phosphatase of regenerating liver (PRL).16
235685632013Protein tyrosine phosphatase 4A2 expression predicts overall and disease-free survival of human breast cancer and is associated with estrogen and progestin receptor status.9

Citation

Dessen P

PTP4A2 (protein tyrosine phosphatase 4A2)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/41907/ptp4a2-(protein-tyrosine-phosphatase-4a2)