PTPRB (protein tyrosine phosphatase receptor type B)

2003-11-01   Dessen P  

Identity

HGNC
PTPRB
LOCATION
12q15
LOCUSID
5787
ALIAS
HPTP-BETA,HPTPB,PTPB,R-PTP-BETA,VEPTP
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 5787
MIM: 176882
HGNC: 9665
Ensembl: ENSG00000127329

Variants:

dbSNP: 5787
ClinVar: 5787
TCGA: ENSG00000127329
COSMIC: PTPRB

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000127329ENST00000261266P23467
ENSG00000127329ENST00000334414P23467
ENSG00000127329ENST00000538708P23467
ENSG00000127329ENST00000547715H0YHE8
ENSG00000127329ENST00000548122Q6ZR19
ENSG00000127329ENST00000550358F8VU56
ENSG00000127329ENST00000550857P23467
ENSG00000127329ENST00000551525F8VSD5

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Adherens junctionKEGGko04520
Adherens junctionKEGGhsa04520
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
361486232023Novel rare mutation in a conserved site of PTPRB causes human hypoplastic left heart syndrome.2
361486232023Novel rare mutation in a conserved site of PTPRB causes human hypoplastic left heart syndrome.2
363973612022The variants in PTPRB, TRAF3IP3, and DISC1 genes were associated with Graves' disease in the Chinese population.1
363973612022The variants in PTPRB, TRAF3IP3, and DISC1 genes were associated with Graves' disease in the Chinese population.1
326635152020PSMD11, PTPRM and PTPRB as novel biomarkers of pancreatic cancer progression.13
326635152020PSMD11, PTPRM and PTPRB as novel biomarkers of pancreatic cancer progression.13
310402662019PTPRB promotes metastasis of colorectal carcinoma via inducing epithelial-mesenchymal transition.9
311251412019Exploring the effect of inhibitor AKB-9778 on VE-PTP by molecular docking and molecular dynamics simulation.8
314273682019Vascular Endothelial Receptor Tyrosine Phosphatase: Identification of Novel Substrates Related to Junctions and a Ternary Complex with EPHB4 and TIE2.10
318292612019miR-624-5p promoted tumorigenesis and metastasis by suppressing hippo signaling through targeting PTPRB in osteosarcoma cells.26
310402662019PTPRB promotes metastasis of colorectal carcinoma via inducing epithelial-mesenchymal transition.9
311251412019Exploring the effect of inhibitor AKB-9778 on VE-PTP by molecular docking and molecular dynamics simulation.8
314273682019Vascular Endothelial Receptor Tyrosine Phosphatase: Identification of Novel Substrates Related to Junctions and a Ternary Complex with EPHB4 and TIE2.10
318292612019miR-624-5p promoted tumorigenesis and metastasis by suppressing hippo signaling through targeting PTPRB in osteosarcoma cells.26
300440462018Collagen regulates the ability of endothelial progenitor cells to protect hypoxic myocardium through a mechanism involving miR-377/VE-PTP axis.3

Citation

Dessen P

PTPRB (protein tyrosine phosphatase receptor type B)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/41924/ptprb-(protein-tyrosine-phosphatase-receptor-type-b)