PTPRC (protein tyrosine phosphatase receptor type C)

2003-11-01  

Identity

HGNC
LOCATION
1q31.3
LOCUSID
ALIAS
B220,CD45,CD45R,GP180,L-CA,LCA,LY5,T200
FUSION GENES

Other Information

Locus ID:

NCBI: 5788
MIM: 151460
HGNC: 9666
Ensembl: ENSG00000081237

Variants:

dbSNP: 5788
ClinVar: 5788
TCGA: ENSG00000081237
COSMIC: PTPRC

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000081237ENST00000348564P08575
ENSG00000081237ENST00000367364M9MMK8
ENSG00000081237ENST00000367367M3ZCP1
ENSG00000081237ENST00000367379M9MMK9
ENSG00000081237ENST00000413409M9MML4
ENSG00000081237ENST00000418674M9MML3
ENSG00000081237ENST00000442510P08575
ENSG00000081237ENST00000529828A0A075B788
ENSG00000081237ENST00000530727E9PKH0
ENSG00000081237ENST00000643513A0A2R8YE81
ENSG00000081237ENST00000645247A0A2R8Y5B1

Expression (GTEx)

0
50
100
150
200
250

Pathways

PathwaySourceExternal ID
Cell adhesion molecules (CAMs)KEGGko04514
T cell receptor signaling pathwayKEGGko04660
Primary immunodeficiencyKEGGko05340
Cell adhesion molecules (CAMs)KEGGhsa04514
T cell receptor signaling pathwayKEGGhsa04660
Primary immunodeficiencyKEGGhsa05340
Fc gamma R-mediated phagocytosisKEGGko04666
Fc gamma R-mediated phagocytosisKEGGhsa04666
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
TCR signalingREACTOMER-HSA-202403
Phosphorylation of CD3 and TCR zeta chainsREACTOMER-HSA-202427
Innate Immune SystemREACTOMER-HSA-168249
Developmental BiologyREACTOMER-HSA-1266738
Axon guidanceREACTOMER-HSA-422475
Semaphorin interactionsREACTOMER-HSA-373755
Other semaphorin interactionsREACTOMER-HSA-416700
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA10004adalimumabChemicalClinicalAnnotationassociatedPD20309874, 23007924
PA164713366Tumor necrosis factor alpha (TNF-alpha) inhibitorsChemicalClinicalAnnotationassociatedPD20309874, 23007924
PA443434Arthritis, RheumatoidDiseaseClinicalAnnotationassociatedPD20309874, 23007924
PA449515etanerceptChemicalClinicalAnnotationassociatedPD20309874, 23007924
PA452639infliximabChemicalClinicalAnnotationassociatedPD20309874, 23007924

References

Pubmed IDYearTitleCitations
169551422006Human CD4+ CD25hi Foxp3+ regulatory T cells are derived by rapid turnover of memory populations in vivo.157
198984812009Genetic variants at CD28, PRDM1 and CD2/CD58 are associated with rheumatoid arthritis risk.131
163329742006Persistence of naive CD45RA+ regulatory T cells in adult life.87
186698612008Regulation of CD45 alternative splicing by heterogeneous ribonucleoprotein, hnRNPLL.84
202316902010Different proliferative potential and migratory characteristics of human CD4+ regulatory T cells that express either CD45RA or CD45RO.68
124993762003The ST6Gal I sialyltransferase selectively modifies N-glycans on CD45 to negatively regulate galectin-1-induced CD45 clustering, phosphatase modulation, and T cell death.64
269987612016Initiation of T cell signaling by CD45 segregation at 'close contacts'.61
187192442008A cell-based screen for splicing regulators identifies hnRNP LL as a distinct signal-induced repressor of CD45 variable exon 4.58
211794142010Characterization of protective human CD4CD25 FOXP3 regulatory T cells generated with IL-2, TGF-β and retinoic acid.58
169984932006Regulation of effector T cells by antigen-presenting cells via interaction of the C-type lectin MGL with CD45.47

Citation

Dessen P

PTPRC (protein tyrosine phosphatase receptor type C)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/41925/ptprc-(protein-tyrosine-phosphatase-receptor-type-c)