PTPRK (protein tyrosine phosphatase receptor type K)

2003-11-01  

Identity

HGNC
LOCATION
6q22.33
LOCUSID
ALIAS
R-PTP-kappa
FUSION GENES

Other Information

Locus ID:

NCBI: 5796
MIM: 602545
HGNC: 9674
Ensembl: ENSG00000152894

Variants:

dbSNP: 5796
ClinVar: 5796
TCGA: ENSG00000152894
COSMIC: PTPRK

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000152894ENST00000368207E9PGC5
ENSG00000152894ENST00000368210Q5TG12
ENSG00000152894ENST00000368213Q15262
ENSG00000152894ENST00000368215Q15262
ENSG00000152894ENST00000368226Q15262
ENSG00000152894ENST00000392449Q6P493
ENSG00000152894ENST00000415046H0Y6P5
ENSG00000152894ENST00000415055H0Y6V4
ENSG00000152894ENST00000490332H0YDP9
ENSG00000152894ENST00000525459E9PRW2
ENSG00000152894ENST00000531050H0YD44
ENSG00000152894ENST00000532331Q15262
ENSG00000152894ENST00000532751E9PMV4

Expression (GTEx)

0
5
10
15
20
25
30

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by EGFRREACTOMER-HSA-177929
EGFR downregulationREACTOMER-HSA-182971

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
177208842008Down-regulation of the TGF-beta target gene, PTPRK, by the Epstein-Barr virus encoded EBNA1 contributes to the growth and survival of Hodgkin lymphoma cells.47
162637242005Receptor-type protein-tyrosine phosphatase-kappa regulates epidermal growth factor receptor function.43
168493272006Oxidative inhibition of receptor-type protein-tyrosine phosphatase kappa by ultraviolet irradiation activates epidermal growth factor receptor in human keratinocytes.40
256126222015Receptor-type tyrosine-protein phosphatase κ directly targets STAT3 activation for tumor suppression in nasal NK/T-cell lymphoma.38
235528692013Protein tyrosine phosphatase kappa (PTPRK) is a negative regulator of adhesion and invasion of breast cancer cells, and associates with poor prognosis of breast cancer.20
269245692016Frequent PTPRK-RSPO3 fusions and RNF43 mutations in colorectal traditional serrated adenoma.20
182761112008PTPRK negatively regulates transcriptional activity of wild type and mutated oncogenic beta-catenin and affects membrane distribution of beta-catenin/E-cadherin complexes in cancer cells.19
248825782015Receptor-type protein tyrosine phosphatase κ directly dephosphorylates CD133 and regulates downstream AKT activation.15
253783492016TGFβ responsive tyrosine phosphatase promotes rheumatoid synovial fibroblast invasiveness.15

Citation

Dessen P

PTPRK (protein tyrosine phosphatase receptor type K)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/41933/ptprk-(protein-tyrosine-phosphatase-receptor-type-k)