Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 5796
MIM: 602545
HGNC: 9674
Ensembl: ENSG00000152894
Variants:
dbSNP: 5796
ClinVar: 5796
TCGA: ENSG00000152894
COSMIC: PTPRK
RNA/Proteins
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Signal Transduction | REACTOME | R-HSA-162582 |
| Signaling by EGFR | REACTOME | R-HSA-177929 |
| EGFR downregulation | REACTOME | R-HSA-182971 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 36436563 | 2023 | Determinants of receptor tyrosine phosphatase homophilic adhesion: Structural comparison of PTPRK and PTPRM extracellular domains. | 2 |
| 36436563 | 2023 | Determinants of receptor tyrosine phosphatase homophilic adhesion: Structural comparison of PTPRK and PTPRM extracellular domains. | 2 |
| 36129915 | 2022 | Investigation of cell signalings and therapeutic targets in PTPRK-RSPO3 fusion-positive colorectal cancer. | 0 |
| 36611909 | 2022 | PTPRK, an EGFR Phosphatase, Is Decreased in CeD Biopsies and Intestinal Organoids. | 2 |
| 36129915 | 2022 | Investigation of cell signalings and therapeutic targets in PTPRK-RSPO3 fusion-positive colorectal cancer. | 0 |
| 36611909 | 2022 | PTPRK, an EGFR Phosphatase, Is Decreased in CeD Biopsies and Intestinal Organoids. | 2 |
| 34590584 | 2021 | A MET-PTPRK kinase-phosphatase rheostat controls ZNRF3 and Wnt signaling. | 3 |
| 34590584 | 2021 | A MET-PTPRK kinase-phosphatase rheostat controls ZNRF3 and Wnt signaling. | 3 |
| 31934854 | 2020 | The tumor suppressor PTPRK promotes ZNRF3 internalization and is required for Wnt inhibition in the Spemann organizer. | 19 |
| 33068671 | 2020 | Simulation of multiple microenvironments shows a pivot role of RPTPs on the control of Epithelial-to-Mesenchymal Transition. | 1 |
| 31934854 | 2020 | The tumor suppressor PTPRK promotes ZNRF3 internalization and is required for Wnt inhibition in the Spemann organizer. | 19 |
| 33068671 | 2020 | Simulation of multiple microenvironments shows a pivot role of RPTPs on the control of Epithelial-to-Mesenchymal Transition. | 1 |
| 30838170 | 2019 | Downregulation of PTPRK Promotes Cell Proliferation and Metastasis of NSCLC by Enhancing STAT3 Activation. | 3 |
| 30924770 | 2019 | The homophilic receptor PTPRK selectively dephosphorylates multiple junctional regulators to promote cell-cell adhesion. | 20 |
| 30947381 | 2019 | PTPRK suppresses progression and chemo-resistance of colon cancer cells via direct inhibition of pro-oncogenic CD133. | 6 |
Citation
Dessen P
PTPRK (protein tyrosine phosphatase receptor type K)
Atlas Genet Cytogenet Oncol Haematol. 2003-11-01
Online version: http://atlasgeneticsoncology.org/gene/41933/ptprk-(protein-tyrosine-phosphatase-receptor-type-k)
