Identity
HGNC
LOCATION
2q35
LOCUSID
ALIAS
IA-2,IA-2/PTP,IA2,ICA512,R-PTP-N
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 5798
MIM: 601773
HGNC: 9676
Ensembl: ENSG00000054356
Variants:
dbSNP: 5798
ClinVar: 5798
TCGA: ENSG00000054356
COSMIC: PTPRN
RNA/Proteins
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Type I diabetes mellitus | KEGG | ko04940 |
| Type I diabetes mellitus | KEGG | hsa04940 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 35040477 | 2022 | Seroreactivity Against Tyrosine Phosphatase PTPRN Links Type 2 Diabetes and Colorectal Cancer and Identifies a Potential Diagnostic and Therapeutic Target. | 5 |
| 35263538 | 2022 | Glutamic Acid Decarboxylase and Tyrosine Phosphatase-Related Islet Antigen-2 Positivity among Children and Adolescents with Diabetes in Korea. | 2 |
| 35040477 | 2022 | Seroreactivity Against Tyrosine Phosphatase PTPRN Links Type 2 Diabetes and Colorectal Cancer and Identifies a Potential Diagnostic and Therapeutic Target. | 5 |
| 35263538 | 2022 | Glutamic Acid Decarboxylase and Tyrosine Phosphatase-Related Islet Antigen-2 Positivity among Children and Adolescents with Diabetes in Korea. | 2 |
| 32696593 | 2021 | Different interaction of onset age and duration of type 1 diabetes on the dynamics of autoantibodies to insulinoma-associated antigen-2 and zinc transporter 8. | 5 |
| 32696593 | 2021 | Different interaction of onset age and duration of type 1 diabetes on the dynamics of autoantibodies to insulinoma-associated antigen-2 and zinc transporter 8. | 5 |
| 29742497 | 2018 | Prognostic Value of Phosphotyrosine Phosphatases in Hepatocellular Carcinoma. | 14 |
| 29742497 | 2018 | Prognostic Value of Phosphotyrosine Phosphatases in Hepatocellular Carcinoma. | 14 |
| 26564179 | 2016 | Influence of HLA-DR and -DQ alleles on autoantibody recognition of distinct epitopes within the juxtamembrane domain of the IA-2 autoantigen in type 1 diabetes. | 0 |
| 26836020 | 2016 | Biochemical, biophysical, and functional properties of ICA512/IA-2 RESP18 homology domain. | 6 |
| 27881117 | 2016 | Novel prokaryotic expression of thioredoxin-fused insulinoma associated protein tyrosine phosphatase 2 (IA-2), its characterization and immunodiagnostic application. | 5 |
| 26564179 | 2016 | Influence of HLA-DR and -DQ alleles on autoantibody recognition of distinct epitopes within the juxtamembrane domain of the IA-2 autoantigen in type 1 diabetes. | 0 |
| 26836020 | 2016 | Biochemical, biophysical, and functional properties of ICA512/IA-2 RESP18 homology domain. | 6 |
| 27881117 | 2016 | Novel prokaryotic expression of thioredoxin-fused insulinoma associated protein tyrosine phosphatase 2 (IA-2), its characterization and immunodiagnostic application. | 5 |
| 25528004 | 2015 | The minimal promoter region of the dense-core vesicle protein IA-2: transcriptional regulation by CREB. | 0 |
Citation
Dessen P
PTPRN (protein tyrosine phosphatase receptor type N)
Atlas Genet Cytogenet Oncol Haematol. 2003-11-01
Online version: http://atlasgeneticsoncology.org/gene/41935/ptprn-(protein-tyrosine-phosphatase-receptor-type-n)
