PTPRT (protein tyrosine phosphatase receptor type T)

2003-12-01  

Identity

HGNC
PTPRT
LOCATION
20q12
LOCUSID
11122
ALIAS
R-PTP-T,RPTP-rho,RPTPrho
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 11122
MIM: 608712
HGNC: 9682
Ensembl: ENSG00000196090

Variants:

dbSNP: 11122
ClinVar: 11122
TCGA: ENSG00000196090
COSMIC: PTPRT

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000196090ENST00000356100B1AJR8
ENSG00000196090ENST00000373184B1AJR9
ENSG00000196090ENST00000373187O14522
ENSG00000196090ENST00000373190B1AJR6
ENSG00000196090ENST00000373193O14522
ENSG00000196090ENST00000373198A0A075B6H0
ENSG00000196090ENST00000373201B1AJS0
ENSG00000196090ENST00000612229A0A087WY22
ENSG00000196090ENST00000617474A0A087X1J1
ENSG00000196090ENST00000618610A0A087X1X2
ENSG00000196090ENST00000620410A0A087WWD6

Expression (GTEx)

0
5
10
15
20
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
382169252024Downregulation of PTPRT elevates the expression of survivin and promotes the proliferation, migration, and invasion of lung adenocarcinoma.0
382169252024Downregulation of PTPRT elevates the expression of survivin and promotes the proliferation, migration, and invasion of lung adenocarcinoma.0
370546262023Novel genetic variants linked to prelabor rupture of membranes among Chinese pregnant women.0
370546262023Novel genetic variants linked to prelabor rupture of membranes among Chinese pregnant women.0
357896442022Association of PTPRT Mutations with Cancer Metastasis in Multiple Cancer Types.4
357896442022Association of PTPRT Mutations with Cancer Metastasis in Multiple Cancer Types.4
344142332021PTPRT Could Be a Treatment Predictive and Prognostic Biomarker for Breast Cancer.5
344142332021PTPRT Could Be a Treatment Predictive and Prognostic Biomarker for Breast Cancer.5
315958322020PTPRT epigenetic silencing defines lung cancer with STAT3 activation and can direct STAT3 targeted therapies.11
315958322020PTPRT epigenetic silencing defines lung cancer with STAT3 activation and can direct STAT3 targeted therapies.11
318440682019Recurrent PTPRT/JAK2 mutations in lung adenocarcinoma among African Americans.17
318440682019Recurrent PTPRT/JAK2 mutations in lung adenocarcinoma among African Americans.17
287969772017A novel de novo 20q13.11q13.12 microdeletion in a boy with neurodevelopmental disorders - case report.2
287969772017A novel de novo 20q13.11q13.12 microdeletion in a boy with neurodevelopmental disorders - case report.2
259822822016Frequent promoter hypermethylation of PTPRT increases STAT3 activation and sensitivity to STAT3 inhibition in head and neck cancer.31

Citation

Dessen P

PTPRT (protein tyrosine phosphatase receptor type T)

Atlas Genet Cytogenet Oncol Haematol. 2003-12-01

Online version: http://atlasgeneticsoncology.org/gene/41939/ptprt-(protein-tyrosine-phosphatase-receptor-type-t)