PUM2 (pumilio RNA binding family member 2)

2003-05-01  

Identity

HGNC
PUM2
LOCATION
2p24.1
LOCUSID
23369
ALIAS
PUMH2,PUML2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 23369
MIM: 607205
HGNC: 14958
Ensembl: ENSG00000055917

Variants:

dbSNP: 23369
ClinVar: 23369
TCGA: ENSG00000055917
COSMIC: PUM2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000055917ENST00000319801A0A0A0MR59
ENSG00000055917ENST00000338086Q8TB72
ENSG00000055917ENST00000361078Q8TB72
ENSG00000055917ENST00000403432Q8TB72
ENSG00000055917ENST00000424110C9JE24
ENSG00000055917ENST00000429419F8WD57
ENSG00000055917ENST00000432105F2Z366
ENSG00000055917ENST00000440577A0A0C4DG68
ENSG00000055917ENST00000442400C9JW01
ENSG00000055917ENST00000446940F2Z366

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
365365162023RNA-binding protein PUM2 promotes T-cell acute lymphoblastic leukemia via competitively binding to RBM5 3'UTR with miR-28-5p.0
365365162023RNA-binding protein PUM2 promotes T-cell acute lymphoblastic leukemia via competitively binding to RBM5 3'UTR with miR-28-5p.0
333976882021Human Pumilio proteins directly bind the CCR4-NOT deadenylase complex to regulate the transcriptome.27
335426252021CAFs-Derived Exosomal miRNA-130a Confers Cisplatin Resistance of NSCLC Cells Through PUM2-Dependent Packaging.20
335764372021Downregulated expression levels of USP46 promote the resistance of ovarian cancer to cisplatin and are regulated by PUM2.4
333976882021Human Pumilio proteins directly bind the CCR4-NOT deadenylase complex to regulate the transcriptome.27
335426252021CAFs-Derived Exosomal miRNA-130a Confers Cisplatin Resistance of NSCLC Cells Through PUM2-Dependent Packaging.20
335764372021Downregulated expression levels of USP46 promote the resistance of ovarian cancer to cisplatin and are regulated by PUM2.4
315959812020RNA-binding protein PUM2 regulates mesenchymal stem cell fate via repression of JAK2 and RUNX2 mRNAs.15
323161902020Characterization of RNP Networks of PUM1 and PUM2 Post-Transcriptional Regulators in TCam-2 Cells, a Human Male Germ Cell Model.5
324374722020Effects of PUMILIO1 and PUMILIO2 knockdown on cardiomyogenic differentiation of human embryonic stem cells culture.2
327534082020Principles of mRNA control by human PUM proteins elucidated from multimodal experiments and integrative data analysis.11
329454772020LncRNA TTN‑AS1 promotes endometrial cancer by sponging miR‑376a‑3p.10
315959812020RNA-binding protein PUM2 regulates mesenchymal stem cell fate via repression of JAK2 and RUNX2 mRNAs.15
323161902020Characterization of RNP Networks of PUM1 and PUM2 Post-Transcriptional Regulators in TCam-2 Cells, a Human Male Germ Cell Model.5

Citation

Dessen P

PUM2 (pumilio RNA binding family member 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/41950/pum2-(pumilio-rna-binding-family-member-2)