Identity
HGNC
LOCATION
15q21.3
LOCUSID
ALIAS
GS2,HsT18676,RAB27,RAM
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 5873
MIM: 603868
HGNC: 9766
Ensembl: ENSG00000069974
Variants:
dbSNP: 5873
ClinVar: 5873
TCGA: ENSG00000069974
COSMIC: RAB27A
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA128406956 | fluorouracil | Chemical | VariantAnnotation | not associated | PD | ||
| PA166182763 | emapalumab | Chemical | LabelAnnotation | associated | |||
| PA443560 | Breast Neoplasms | Disease | VariantAnnotation | not associated | PD | ||
| PA444773 | Leukopenia | Disease | VariantAnnotation | not associated | PD | ||
| PA445113 | Neutropenia | Disease | VariantAnnotation | not associated | PD | ||
| PA449165 | cyclophosphamide | Chemical | VariantAnnotation | not associated | PD | ||
| PA449383 | docetaxel | Chemical | VariantAnnotation | not associated | PD | ||
| PA449476 | epirubicin | Chemical | VariantAnnotation | not associated | PD |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38326867 | 2024 | circ_0029463 promotes osteoclast differentiation by mediating miR-134-5p/Rab27a axis. | 1 |
| 38326867 | 2024 | circ_0029463 promotes osteoclast differentiation by mediating miR-134-5p/Rab27a axis. | 1 |
| 37202191 | 2023 | [Silencing RAB27a inhibits proliferation, invasion and adhesion of triple-negative breast cancer cells]. | 0 |
| 37231020 | 2023 | Rab27a-mediated extracellular vesicle secretion contributes to osteogenesis in periodontal ligament-bone niche communication. | 3 |
| 37249278 | 2023 | Expression and significant roles of the lncRNA NEAT1/miR-493-5p/Rab27A axis in ulcerative colitis. | 1 |
| 37368332 | 2023 | Molecular findings and clinical manifestations of 18 Iranian children with Griscelli syndrome type 2: Two novel homozygote mutations in RAB27A gene in a patient. | 0 |
| 37388727 | 2023 | Immunodeficiency with susceptibility to lymphoma with complex genotype affecting energy metabolism (FBP1, ACAD9) and vesicle trafficking (RAB27A). | 0 |
| 37641131 | 2023 | SMC3 epigenetic silencing regulates Rab27a expression and drives pancreatic cancer progression. | 0 |
| 37685910 | 2023 | Overexpression of RAB27A in Oral Squamous Cell Carcinoma Promotes Tumor Migration and Invasion via Modulation of EGFR Membrane Stability. | 2 |
| 37202191 | 2023 | [Silencing RAB27a inhibits proliferation, invasion and adhesion of triple-negative breast cancer cells]. | 0 |
| 37231020 | 2023 | Rab27a-mediated extracellular vesicle secretion contributes to osteogenesis in periodontal ligament-bone niche communication. | 3 |
| 37249278 | 2023 | Expression and significant roles of the lncRNA NEAT1/miR-493-5p/Rab27A axis in ulcerative colitis. | 1 |
| 37368332 | 2023 | Molecular findings and clinical manifestations of 18 Iranian children with Griscelli syndrome type 2: Two novel homozygote mutations in RAB27A gene in a patient. | 0 |
| 37388727 | 2023 | Immunodeficiency with susceptibility to lymphoma with complex genotype affecting energy metabolism (FBP1, ACAD9) and vesicle trafficking (RAB27A). | 0 |
| 37641131 | 2023 | SMC3 epigenetic silencing regulates Rab27a expression and drives pancreatic cancer progression. | 0 |
Citation
Dessen P
RAB27A (RAB27A, member RAS oncogene family)
Atlas Genet Cytogenet Oncol Haematol. 2003-11-01
Online version: http://atlasgeneticsoncology.org/gene/41972/rab27a-(rab27a-member-ras-oncogene-family)
