RGL2 (ral guanine nucleotide dissociation stimulator like 2)

2003-11-01  

Identity

HGNC
RGL2
LOCATION
6p21.32
LOCUSID
5863
ALIAS
HKE1.5,KE1.5,RAB2L
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 5863
MIM: 602306
HGNC: 9769
Ensembl: ENSG00000237441

Variants:

dbSNP: 5863
ClinVar: 5863
TCGA: ENSG00000237441
COSMIC: RGL2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000237441ENST00000425946A2AB89
ENSG00000237441ENST00000497454O15211
ENSG00000237441ENST00000497454A0A024RCS9

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Ras signaling pathwayKEGGhsa04014

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
211604982011Functional characterization of SAMD9, a protein deficient in normophosphatemic familial tumoral calcinosis.38
211604982011Functional characterization of SAMD9, a protein deficient in normophosphatemic familial tumoral calcinosis.38
208018772010Aberrant overexpression of the Rgl2 Ral small GTPase-specific guanine nucleotide exchange factor promotes pancreatic cancer growth through Ral-dependent and Ral-independent mechanisms.36
208018772010Aberrant overexpression of the Rgl2 Ral small GTPase-specific guanine nucleotide exchange factor promotes pancreatic cancer growth through Ral-dependent and Ral-independent mechanisms.36
198514452009High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions.58
198514452009High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions.58
185408612008G-protein binding features and regulation of the RalGDS family member, RGL2.2
185408612008G-protein binding features and regulation of the RalGDS family member, RGL2.2

Citation

Dessen P

RGL2 (ral guanine nucleotide dissociation stimulator like 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/41976/rgl2-(ral-guanine-nucleotide-dissociation-stimulator-like-2)